Radioiodine Refractory Differentiated Thyroid Cancer

Chan, Wendy; Chan, Sonia; Kwong, Dora Lai Wan

doi:10.1007/978-1-0716-2505-7_17

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…So far, RAI has been the most often used additional treatment for patients with intermediate- or high-risk of disease recurrence or metastatic DTC ( 55 ). However, patients with advanced DTC either have inherent resistance or develop resistance to this treatment ( 56 ). Additionally, MTC and anaplastic TC do not exhibit a valuable response to RAI therapy due to their inability to metabolize iodine.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic yield of FAP-guided positron emission tomography in thyroid cancer: a systematic review

Rizzo,

Albano,

Dondi

et al. 2024

Front. Med.

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BackgroundSeveral recent studies have proposed the possible application of positron emission tomography/computed tomography (PET/CT) administering radiolabelled fibroblast-activation protein (FAP) inhibitors for various forms of thyroid cancer (TC), including differentiated TC (DTC), and medullary TC (MTC).MethodsThe authors conducted an extensive literature search of original studies examining the effectiveness of FAP-guided PET/CT in patients with TC. The papers included were original publications exploring the use of FAP-targeted molecular imaging in restaging metastatic DTC and MTC patients.ResultsA total of 6 studies concerning the diagnostic yield of FAP-targeted PET/CT in TC (274 patients, of which 247 DTC and 27 MTC) were included in this systematic review. The included articles reported high values of FAP-targeted PET/CT detection rates in TC, ranging from 81 to 100% in different anatomical sites and overall superior to the comparative imaging method.ConclusionAlthough there are promising results, the existing literature on the diagnostic accuracy of FAP-guided PET in this context is still quite limited. To thoroughly evaluate its potential significance in TC patients, it is needed to conduct prospective randomized multicentric trials.

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Section: Discussionmentioning

confidence: 99%