Radioiodinated meta-iodobenzylguanidine uptake in medullary thyroid cancer: A French cooperative study

Baulieu, Jean-Louis; Guilloteau, Denis; Delisle, M. J.; Perdrisot, R.; Gardet, P; Delepine, N.; Baulieu, F.; Dupont, Jean-Louis; Talbot, Jean-Noël; Coutris, G; Calmettes, C

doi:10.1002/1097-0142(19871101)60:9<2189::aid-cncr2820600913>3.0.co;2-c

Cited by 44 publications

(22 citation statements)

References 7 publications

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“…30%) [7,19], and other radiopharmaceuticals designed to be tumour specific, e.g. DMSA V [20] or radiolabelled antibodies [21], have been proposed.…”

Section: Discussionmentioning

confidence: 99%

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Utility of thallium-201 and iodine-123 metaiodobenzylguanidine in the scintigraphic detection of neuroendocrine neoplasia

et al. 1993

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Metaiodobenzylguanidine (MIBG) is a specific marker for neuroendocrine tumours, such as phaeochromocytoma, neuroblastoma, medullary thyroid cancer (MTC) and paraganglioma, but it suffers in some cases (especially in MTC) from a lack of sensitivity. Thallium is a well-known marker of cellularity with a great sensitivity and a lack of specificity. In order to determine whether the association of these two markers is able to improve the detection of neuroendocrine lesions, 137 scintigraphic examinations using MIBG and thallium were performed in 101 patients referred for suspicion or follow-up of neuroendocrine tumours. Thallium chloride was first injected (1 MBq/kg), images being acquired about 20 min after injection; 123I-MIBG (4 MBq/kg) was then injected and images acquired 5 and 24 h later. In patients with phaeochromocytoma or neuroblastoma, thallium scintigraphy appeared of little help since no tumoural site was discovered by thallium accumulation alone. In contrast, thallium examination seemed of interest in the detection of paraganglioma and MTC, the association of the two radiopharmaceuticals increasing the number of detected sites.

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“…30%) [7,19], and other radiopharmaceuticals designed to be tumour specific, e.g. DMSA V [20] or radiolabelled antibodies [21], have been proposed.…”

Section: Discussionmentioning

confidence: 99%

“…However, we think that one MIBG scan remains useful before surgery in MTC in order to search for an associated phaeochromocytoma. Follow-up scans are indicated only if calcitonin levels are elevated and should comprise MIBG scans only if the primary tumour took up this radiopharmaceutical [19].…”

Section: Discussionmentioning

confidence: 99%

Utility of thallium-201 and iodine-123 metaiodobenzylguanidine in the scintigraphic detection of neuroendocrine neoplasia

et al. 1993

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“…In the present patient, the fine-needle aspiration cytology of the left thyroid mass was negative, but based on the elevated serum calcitonin level and the response to the tetragastrin test, medullary thyroid carcinoma is strongly suspected. In patients with MEN 2A, MIBG scintiscan is useful not only in detecting associated pheochromocytoma, but also in diagnosing medullary thyroid carcinoma (10). MIBG scintigraphy is planned for the present patient in the near future.…”

Section: Case Reportmentioning

confidence: 99%

Multiple Endocrine Neoplasia Type 2A.

Shimizu¹,

Ueda²,

Makino³

et al. 1992

Intern. Med.

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A 40-year-old woman was admitted with complaints of headache, palpitation and diaphore sis. She had undergone right hemithyroidectomy 12 years previously. Histological reexamination of the operative specimen revealed a medullary thyroid carcinoma. Abdominal ultrasonography, CT scan and angiography showed bilateral adrenal tumors. Serum catecholamine levels in both adrenal veins were high. Based on these data, bilateral adrenalectomy was performed. Histological examination confirmed the diagnosis of pheochromocytomas. After operation, serum calcitonin and urinary noradrenaline levels were still high. Further examination by 131I-metaiodobenzylguanidine (MIBG) scintigraphy is planned. (Internal Medicine 31: 798-802, 1992)

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“…MRI has similar indications and it can also be used in the evaluation of the mediastinum (Crow et al, 1989). Various [99mTc](V)DMSA, 1111231_MIBG and 201T1 show different sensitivities of lesion detection in different reports (Arnstein et al, 1986;Hilditch et al, 1986Hilditch et al, , 1987Baulieu et al, 1987;Clarke et al, 1987 Clarke et al, , 1988Hoefnagel et al, 1988;Adams et al, 1990;Guerra et al, 1989;Charkes et al, 1990;Udelsman et al, 1993). These different sensitivities can be related to patient selection, limited number of patients studied, Ct blood levels, dimension of lesions studied or to methodological problems.…”

mentioning

confidence: 99%

“…Several methods based on tumour avidity of non-specific radiopharmaceuticals such as [99"Tc](V)DMSA, '3I11231-MIBG and 20'T1 have also been designed for this purpose, with variable results (Arnstein et al, 1986;Hilditch et al, 1986;Baulieu et al, 1987;Clarke et al, 1987;Hilditch, 1987; Clarke et al, 1988;Hoefnagel et al, 1988;Guerra et al, 1989;Adams et al, 1990;Charkes et al, 1990;Udelsman et al, 1993).…”

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confidence: 99%

Pretargeted immunoscintigraphy in patients with medullary thyroid carcinoma

Magnani

Paganelli²,

Songini³

et al. 1996

Br J Cancer

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Summary To evaluate the use of pretargeted immunoscintigraphy (ISG) in the diagnosis and follow-up of patients with medullary thyroid carcinoma (MTC), we studied 25 patients with histologically proven disease; ISG was repeated after surgery in two patients. The antibody, either an anticarcinoembryonic antigen (CEA) or an antichromogranin A (CgA) biotinylated monoclonal antibody (MAb) or a cocktail of the two biotinylated MAbs was first injected. After 24 h, avidin was administrated i.v., followed by "'In-labelled biotin 24 h later. Fifty-two lesions were visualised. Six primary tumours, diagnosed by increased calcitonin levels, were all correctly diagnosed; 47 recurrences, also suspected by blood tumour markers, were detected and confirmed by cytology or histology. In one case, single photon emission tomography allowed the detection of small lymph nodes with a diameter of 4 -7 mm. These lesions, not judged neoplastic by ultrasound, were confirmed to be neoplastic by fine needle aspiration. Pretargeted ISG correctly localises primary tumours and recurrences in MTC patients, when the only marker of relapse is serum elevation of calcitonin. With this three-step pretargeting method, cocktails of potentially useful MAbs can be used, avoiding false-negative studies that may occur when CEA or CgA are not expressed.Keywords: medullary thyroid carcinoma; monoclonal antibody; avidin-biotin Medullary thyroid carcinoma (MTC) arises from calcitoninsecreting parafollicular cells in the thyroid. Both the sporadic and the familial form are treated by surgery (Chong et al., 1975;Rossi et al., 1980), as the efficacy of radiotherapy is limited (Samaan et al., 1988) and chemotherapy is ineffective (Rougier et al., 1983;Brunt and Wells, 1987). Early diagnosis of recurrence or metastasis and accurate localisation of recurrent disease are very important prerequisites for successful surgical excision.Elevated serum calcitonin (Ct) is considered to be a marker for MTC. High serum levels of Ct and carcinoembryonic antigen (CEA) can often be found in patients with recurrent disease several years before it becomes clinically apparent, but, at present, no efficient and specific method is available for the localisation of recurrences.Morphological imaging techniques (ultrasonography, US; computerised tomography, CT; magnetic resonance imaging, MRI) are routinely used to confirm and localise a biologically detected recurrence but are not always adequate because of topographic polymorphism and the small size of tumour recurrences at an early stage of development (Schwerk et al., 1985;Frank et al., 1987;Crow et al., 1989).Several methods based on tumour avidity of non-specific radiopharmaceuticals such as [99"Tc](V)DMSA, '3I11231-MIBG and 20'T1 have also been designed for this purpose, with variable results (Arnstein et al., 1986;Hilditch et al., 1986;Baulieu et al., 1987;Clarke et al., 1987;Hilditch, 1987; Clarke et al., 1988;Hoefnagel et al., 1988;Guerra et al., 1989;Adams et al., 1990;Charkes et al., 1990;Udelsman et al., 1993).In the attem...

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Radioiodinated meta-iodobenzylguanidine uptake in medullary thyroid cancer: A French cooperative study

Cited by 44 publications

References 7 publications

Utility of thallium-201 and iodine-123 metaiodobenzylguanidine in the scintigraphic detection of neuroendocrine neoplasia

Utility of thallium-201 and iodine-123 metaiodobenzylguanidine in the scintigraphic detection of neuroendocrine neoplasia

Multiple Endocrine Neoplasia Type 2A.

Pretargeted immunoscintigraphy in patients with medullary thyroid carcinoma

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