Radioinduced Modulatory Response of Lipid Profiles of Wistar Rats Brain Monitored by DESI-MS Imaging
Matheus Mingote,
Camila Cristina de Paula,
Tarcísio de Campos
et al.
Abstract:The ionizing radiation used in radiotherapy can break down deoxyribonucleic acid bonds, generate reactive oxygen and nitrogen species, alter intracellular proteins, and induce changes in the lipidome. This study delves into examining lipid classes and their spatial distribution in the brains of Wistar rats exposed to ionizing radiation. Healthy male isogenic Wistar rats (n = 15) were divided into a control group (CG, n = 3) and an irradiated group (IRG, n = 12). The individuals of the IRG group were subjected … Show more
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