Radioimmunoimaging with Mixed Monoclonal Antibodies of Nude Mice Bearing Human Lung Adenocarcinoma Xenografts

Abstract

The present study was conducted to evaluate radioimmunoimaging (RII) and in vivo distribution of mixed antibodies

A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors

“…Smaller antibody fragments or engineered proteins provide a potential source of targeting domains for molecular imaging agents, allowing for improvements of the tumor-to-organ radioactivity concentration ratio and imaging contrast 5 . As such, diverse antibody fragments 6 - 11 and protein scaffolds, including Affibody molecules 12 , fibronectin-derived monobody 13 , nanobodies 14 , and peptides 15 , have been explored for such uses.…”

The Role of Mesothelin Expression in Serous Ovarian Carcinoma: Impact on Diagnosis, Prognosis, and Therapeutic Target

“…Radioimmunoimaging is a type of molecular nuclear medicine imaging that applies specific antibodies of tumour-specific antigens labelled with radionuclides for imaging [36]. Thus, this molecular imaging allows the assessment of the tumour uptake and distribution in the primary and secondary tumour sites as well as the response to therapy.…”

The Role of Mesothelin Expression in Serous Ovarian Carcinoma: Impact on the Diagnosis, Prognosis, and Therapeutic Target

“…Radioimmunoimaging is a type of molecular nuclear medicine imaging that applies specific antibodies of tumour-specific antigens labelled with radionuclides for imaging [37]. Thus, this molecular imaging allows the assessment of the tumour uptake and distribution in the primary and secondary tumour sites as well as the response to therapy.…”