Radioimmunodetection and radioimmunotherapy of head and neck cancer

Börjesson, Pontus K.E.; Postema, Ernst J.; Bree, Remco de; Roos, Jan C.; Leemans, C. René; Kairemo, Kalevi; Dongen, Guus A.M.S. van

doi:10.1016/j.oraloncology.2003.11.009

Cited by 25 publications

(22 citation statements)

References 58 publications

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“…For example, in recent clinical trials, dendritic cell-based immunotherapy was reported to be safe (29,30), and tumor antigen vaccination in combination with IL-12 showed mild adverse effects (Grade I-II) even though the patients in the study had end-stage cancer (31). Radioimmunotherapy has been employed in the field of head and neck squamous cell carcinoma treatment (32)(33)(34) as well as in other cancers (35). However, in these studies, the host immune response evoked via radio-labeled monoclonal antibody was not clearly evaluated.…”

Section: Discussionmentioning

confidence: 99%

Preoperative radiotherapy contributes to induction of proliferative activity of CD8+ tumor-infiltrating T-cells in oral squamous cell carcinoma

Suwa

Saio²,

Umemura³

et al. 2006

Oncol Rep

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Abstract. In order to evaluate host immune response to cancer, many methods have been applied. However, in the field of oral squamous cell carcinoma, evaluation of host immune response on the basis of proliferative activity of tumor-infiltrating T-cells (TIL) has not been reported. Therefore, we applied double immunohistochemical staining of proliferation markers Ki-67 and CD8 to surgically resected and paraffin-embedded tissue sections for 35 cases of oral squamous cell carcinoma. With this method, there was a significant correlation between the percentage of Ki-67 + CD8 + TIL and the intra-tumor epithelium infiltration rate of CD8 + TIL (P=0.0237). In the process of analysis, we found that the proliferative activity of CD8 + TIL tended to correlate (P=0.0859) with clinical N factor (lymph node metastasis), which was previously reported to suppress host immune response. We therefore assumed there was another factor inducing host immune response. The proliferative activity of CD8 + TIL was well correlated with preoperative radiotherapy (P=0.0200) while there was no significant correlation between the proliferative activity of CD8 + TIL and other clinical factors; age, tumor size, clinical stage, pathological N factor (P=0.5410, 0.7769, 0.1041, and 0.1072, respectively). Our present results strongly imply that preoperative radiotherapy is a very important factor in oral squamous cell carcinoma inducing host immune response regardless of the clinical factors present.

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Section: Discussionmentioning

confidence: 99%

Preoperative radiotherapy contributes to induction of proliferative activity of CD8+ tumor-infiltrating T-cells in oral squamous cell carcinoma

Suwa

Saio²,

Umemura³

et al. 2006

Oncol Rep

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“…The bridging assay allows for detection of all immunoglobulin isotypes and classes without the concern of secondary anti-human IgG detection antibody binding to the plate coating antigen or missing specific classes or isotypes of the sample anti-therapeutic antibody. Bridging assays utilizing both one-step [13] and two-step formats [14] have been reported in the literature. Results presented here indicate that the format of the bridging assay can have significant impact on the assay performance, particularly in regard to antigen coating density.…”

Section: Discussionmentioning

confidence: 99%

Effect of double antigen bridging immunoassay format on antigen coating concentration dependence and implications for designing immunogenicity assays for monoclonal antibodies

Bourdage

Lee

Taylor

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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“…The magnitude of this effect relies on the used radionuclide and the tissue penetration depth of emitted radiation and may overcome poor dissemination of the radiotherapeutic drug. 3,22 Taken together, the application of RIT simultaneously with or after EBRT was in most cases beneficial to a schedule where RIT was applied prior to external irradiation. It may not make a difference if fractionated EBRT starts some days prior to RIT injection or on the same day, as mAb circulate for several days.…”

Section: 65mentioning

confidence: 99%

“…b-emitters) can destroy adjacent tumour cells by the crossfire effect, that is through the range of radiation in tissue, cells can be killed without having bound the radionuclide itself. 22 This is regarded as a main advantage of RIT for the treatment of solid tumours as plasticity of tumour cells (e.g. loss of target antigen) and delivery barriers can be overcome by some extent.…”

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confidence: 99%

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Improving external beam radiotherapy by combination with internal irradiation

Dietrich¹,

Koi²,

Zöphel³

et al. 2015

BJR

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The efficacy of external beam radiotherapy (EBRT) is dose dependent, but the dose that can be applied to solid tumour lesions is limited by the sensitivity of the surrounding tissue. The combination of EBRT with systemically applied radioimmunotherapy (RIT) is a promising approach to increase efficacy of radiotherapy. Toxicities of both treatment modalities of this combination of internal and external radiotherapy (CIERT) are not additive, as different organs at risk are in target. However, advantages of both single treatments are combined, for example, precise high dose delivery to the bulk tumour via standard EBRT, which can be increased by addition of RIT, and potential targeting of micrometastases by RIT. Eventually, theragnostic radionuclide pairs can be used to predict uptake of the radiotherapeutic drug prior to and during therapy and find individual patients who may benefit from this treatment. This review aims to highlight the outcome of pre-clinical studies on CIERT and resultant questions for translation into the clinic. Few clinical data are available until now and reasons as well as challenges for clinical implementation are discussed.

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Radioimmunodetection and radioimmunotherapy of head and neck cancer

Cited by 25 publications

References 58 publications

Preoperative radiotherapy contributes to induction of proliferative activity of CD8+ tumor-infiltrating T-cells in oral squamous cell carcinoma

Preoperative radiotherapy contributes to induction of proliferative activity of CD8+ tumor-infiltrating T-cells in oral squamous cell carcinoma

Effect of double antigen bridging immunoassay format on antigen coating concentration dependence and implications for designing immunogenicity assays for monoclonal antibodies

Improving external beam radiotherapy by combination with internal irradiation

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