Radioimmunoassay of carcinoembryonic antigen in serum of normal subjects and patients with colonic carcinoma

Kleinman, Martin S.; Turner, Michael D.

doi:10.1136/gut.13.5.390

Cited by 16 publications

(7 citation statements)

References 10 publications

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“…Moreover, it has been found that the sera of a high proportion of patients with early carcinoma of the colon have assayable CEA levels in the same range as that seen in normal subjects [6],…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have shown that material which reacts in a similar manner to CEA in the assay system is found in normal tissues and serum in low concentrations [6,8,9] and at present it is by no means certain that CEA occurs only in tumors or fetal tissues. Moreover, it has been found that the sera of a high proportion of patients with early carcinoma of the colon have assayable CEA levels in the same range as that seen in normal subjects [6],…”

Section: Discussionmentioning

confidence: 99%

“…The system employed 125I-CEA, and rabbit anti-CEA, and depended upon the use of 50% ammonium sulfate for separation of antibody-bound and unbound '" I-CEA. Sera from normal subjects have been found to inhibit the assay to an extent equivalent to not more than 2.8 ng CEA/ml serum [6], 17 patients were considered to have ulcerative proctitis (table I), 30 ulcerative colitis (table II), and 31 Crohn's disease (table HI). Of the patients with Crohn's disease, 7 had demonstrable disease only in the colon, 8 in the small intestine and colon, and 16 only in the small intestine (table III).…”

Section: Methodsmentioning

confidence: 99%

“…The majority of patients with colonic carcinoma show elevated levels of serum CEA [6,8,10,14], the levels ap parently increasing with the extent of the disease [6,8], Since the incidence of colonic carcinoma in patients with ulcerative colitis is increased [1.2] it seemed possible that measurement of serum CEA levels might be of value in the screening of such patients for carcinoma. This paper reports the assay of CEA in the serum of 78 patients with chronic inflammatory bowel disease.…”

mentioning

confidence: 99%

“…Previous reports [3][4][5] have described the preparation of absorbed rabbit antisera (anti-CEA) which react with a material, extractable from human colonic carcinoma, which has been called the 'carcinoenibryonic antigen of the digestive system" (CEA) [3], The preparation of radioiodinated antigen (125I-CEA) and its use in a radioimmunoassay system for circulating CEA have also been reported [6,14,15]. The majority of patients with colonic carcinoma show elevated levels of serum CEA [6,8,10,14], the levels ap parently increasing with the extent of the disease [6,8], Since the incidence of colonic carcinoma in patients with ulcerative colitis is increased [1.2] it seemed possible that measurement of serum CEA levels might be of value in the screening of such patients for carcinoma.…”

mentioning

confidence: 99%

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Serum Carcinoembryonic Antigen (CEA) in Patients with Chronic Inflammatory Bowel Disease

Turner¹,

Kleinman²,

Thayer³

1973

Digestion

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Serum CEA was measured in 78 patients with chronic inflammatory bowel disease. One of 17 patients with ulcerative proctitis, 3 of 30 with ulcerative colitis and 4 of 31 with Crohn’s disease had elevated serum levels of CEA. All patients with increased levels had symptomatic disease. There was no evidence for the presence of carcinoma of the colon in these patients. It is unlikely that single measurements of serum CEA by presently available tests will be of value as a screening procedure for early carcinoma of thecolon in the presence of chronic inflammatory bowel disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Serum Carcinoembryonic Antigen (CEA) in Patients with Chronic Inflammatory Bowel Disease

Turner¹,

Kleinman²,

Thayer³

1973

Digestion

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Carcinoembryonic antigen in patients suffering from ulcerative proctocolitis

Mitchell

Gill²,

Orchard³

et al. 1975

Digest Dis Sci

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Carcinoembryonic antigen (CEA) has been measured by radioimmunoassay in samples obtained from all patients suffering from ulcerative proctocolitis and seen within a four-month period. The characteristics of this group of patients have been compared with reported epidemiological studies in this disease, and have been found to have a similar sex ratio and age of onset, but a more limited disease. Among 59 patients, 11 were found to have elevated circulating CEA values. One of the 11 had a colonic carcinoma and another was pregnant. Excluding these two patients, an overall prevalence of elevated CEA levels of 17.5% was found. The prevelance in ulcerative proctitis was 7.1%, and in colitis was 19.9%. The patients in whom elelvated plasma CEA values were found were compared with the remaining patients in relation to factors known to be associated with an increased propensity for the development of colorectal carcinoma complicating ulcerative colitis. There was no difference in mean age of the patients at disease onset, nor was there any difference in disease duration, extent, and control. A significant correlation was found between elevated plasma CEA levels and the severity of the initial attack. One patient with premalignant changes in the rectal mucosa had consistently normal concentrations of plasma CEA. There was no significant correlation between elevated plasma CEA values and disease activity. The mean age of the two groups of patients was similar. No carcinoma has manifested in any patient during follow-up periods of at least 18 months.

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Carcinofetal antigens. III. Further carcinofetal antigens

Lamerz

Fateh‐Moghadam

1975

Klin Wochenschr

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The occurrance and significance of important carcinofetal antigens other than AFP and CEA are reported. These included the alpha 2 H-protein which is produced in the liver and increases in serum of patients with various tumors, the fetal sulphoglycoprotein antigen FSA from the gastric juice of patients with gastric cancer, the carcinoplacental alkaline phosphatase (REGAN-isoenzyme)which is found in the serum of patients suffering from e.g. bronchogenic, mammary, urogenital and gastrointestinal carcinomas, the beta-S-fetoprotein which is most likely to be identical with C-reactive protein, gamma-fetoprotein, the carcinofetal antigen in glial tumors (CFGA); ectopic production of placental hormones like human gonadotropin, placental lactogen, plasminogen-activators; leukemia-associated antigens. Furthermore, some other less known carcinofetal antigens are mentioned.

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Radioimmunoassay of carcinoembryonic antigen in serum of normal subjects and patients with colonic carcinoma

Cited by 16 publications

References 10 publications

Serum Carcinoembryonic Antigen (CEA) in Patients with Chronic Inflammatory Bowel Disease

Serum Carcinoembryonic Antigen (CEA) in Patients with Chronic Inflammatory Bowel Disease

Carcinoembryonic antigen in patients suffering from ulcerative proctocolitis

Carcinofetal antigens. III. Further carcinofetal antigens

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