Radioimmunoassay of arginine vasopressin in human plasma and urine, a resin microcolumn method.

Kimura, Tokihisa; Matsui, Kuniaki; Ota, Kozo; Yoshinaga, Kaoru

doi:10.1620/tjem.131.37

Cited by 21 publications

(13 citation statements)

References 15 publications

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“…Plasma AVP and ANH were determined using RIAs as previously reported (12,13). Briefly, AVP and ANH were extracted using a resin microcolumn method and an octadecylsilane cartridge (Sep-Pak C18, Waters Associates, Inc., Milford, MA, USA) respectively.…”

Section: Measurementsmentioning

confidence: 99%

Impaired vasopressin suppression and enhanced atrial natriuretic hormone release following an acute water load in primary aldosteronism

Kimura

Yamamoto²,

Ohta³

et al. 1997

European Journal of Endocrinology

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The release of arginine vasopressin (AVP) and atrial natriuretic hormone (ANH) and their involvement in renal water and electrolyte metabolism in primary aldosteronism in humans were studied. An oral acute water load (20 ml/kg body weight) was given to each of 12 patients before and after surgical removal of their aldosterone-producing adenoma(s). Plasma AVP and ANH were measured simultaneously, and renal water and electrolyte metabolism and tubular functions were determined. The same water load was given to seven normal subjects and the same parameters were determined. In the presence of mineralocorticoid excess before the operation, plasma AVP was relatively low compared with plasma osmolality (Posm), but was not suppressed in response to decreases in Posm after the water load. Baseline plasma ANH was high and increased further after the water load; urinary dilution and diuresis both remained normal. After the operation, baseline plasma AVP was normal and decreased in response to the decrease in Posm after the water load, with normal urinary dilution and diuresis. Baseline plasma ANH was normal, and did not increase after the water load. The ratio of urinary K and Na clearances and distal tubular reabsorption of Na increased before the operation. These results suggest that there are perturbations of AVP and ANH release in primary aldosteronism, despite the normal urinary dilution after a water load. European Journal of Endocrinology 137 154-161

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Section: Measurementsmentioning

confidence: 99%

Impaired vasopressin suppression and enhanced atrial natriuretic hormone release following an acute water load in primary aldosteronism

Kimura

Yamamoto²,

Ohta³

et al. 1997

European Journal of Endocrinology

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“…Serum Na and glucose were ranging from 125 to 140 mmol/l and from 6.0 to 12.0 mmol/l, respectively. In the present study, plasma ADH and ANP were determined by means of radioimmunoassays previously reported elsewhere [10,11] about 1000 ml of water was given. Under this regimen serum Na was maintained within the normal range.…”

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confidence: 93%

A Case of Syndrome of Inappropriate Secretion of Antidiuretic Hormone Associated with Diabetes Mellitus.

et al. 1991

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Abstract. A 46-year-old man, presenting with headache, nausea, and lassitude, was diagnosed as having diabetes mellitus and hyponatremia, and admitted to Tohoku University Hospital. Insulin treatment improved the hyperglycemia but aggravated hyponatremia, which was proved to be elicited by the inappropriate secretion of antidiuretic hormone (SIADH). An acute water load failed to suppress ADH release in the supine posture but slightly increased plasma atrial natriuretic peptide (ANP). On the other hand, plasma ADH markedly increased in response to an upright posture, accompanied by a fall in blood pressure and a rise in heart rate. After treatment with droxidopa"a sympathomimetic drug", ambulatory blood pressure gradually increased and hyponatremia disappeared. However, blood pressure and ADH responses to upright posture were not improved by treatment with the drug. Moreover, plasma ADH was still not sufficiently suppressed by acute water loading in the supine position, but plasma ANP markedly increased, thereby resulting in urinary dilution and natriuresis. These results suggest that exaggerated ADH release (SIADH) was brought about by the baroreceptor reflex stimulated by the postural hypotension, and also by the impaired osmoregulation associated with diabetic neuropathy, and that droxidopa improved cardiovascular function and increased ANP release with resultant urinary dilution and natriuresis in spite of slightly increased ADH release.

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“…Plasma AVP was determined by RIA as reported elsewhere (Kimura et al 1980). Briefly, AVP was extracted using a resin micro-column method.…”

Section: Methodsmentioning

confidence: 99%

Changes in Plasma Vasopressin Levels and Cardiovascular Function due to Postural Changes in Diabetic Neuropathy.

Sato

Kimura

Ota

et al. 1995

Tohoku J. Exp. Med.

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Decreases in blood pressure are well known to increase the release of vasopressin. Studies were carried out to investigate whether vasopressin responses to postural changes in blood pressure are maintained in diabetic patients with orthostatic hypotension [DM-OH( +)] as well as non-diabetic patients with orthostatic hypotension [nonDM-OH( +)] and these responses were compared with them observed in normal subjects and diabetic patients without orthostatic hypotension [DM-OH( -)] . After 30 min in the supine position, the upright posture for 40 min was maintained and then the supine for 10 min. Blood pressure and heart rate (HR) were measured every 5 min and plasma vasopressin levels (plasma AVP) were determined every 10 min. In normal subjects and DM-OH( -), mean arterial blood pressure (MABP) did not change, but HR increased significantly by the upright position. Plasma AVP did not change in these group. On the other hand, in DM-OH( +) MABP fell abruptly and remained to decrease during the upright posture. The HR responses in this group, however, were similar to those in normal control and DM-OH( -). Plasma AVP in DM-OH( + ) significantly increased only at 30 min during upright. These increases were significantly greater than those in normal and DM-OH( -). There were significant correlation in changes in MABP (JMAP) and plasma AVP (zJAVP) in DM-OH( +) p<0.01).Relationship between aMABP and QAVP in nonDM-OH( +) was similar to that in DM-OH( +). It is concluded that AVP responses to orthostatic hypotension in diabetic and nondiabetic neuropathies were attenuated, but heart rate responses in these patients ware well reserved. hypotension; diabetes mellitus; blood pressure; heart rate; baroreflex

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Radioimmunoassay of arginine vasopressin in human plasma and urine, a resin microcolumn method.

Cited by 21 publications

References 15 publications

Impaired vasopressin suppression and enhanced atrial natriuretic hormone release following an acute water load in primary aldosteronism

Impaired vasopressin suppression and enhanced atrial natriuretic hormone release following an acute water load in primary aldosteronism

A Case of Syndrome of Inappropriate Secretion of Antidiuretic Hormone Associated with Diabetes Mellitus.

Changes in Plasma Vasopressin Levels and Cardiovascular Function due to Postural Changes in Diabetic Neuropathy.

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