Radiohalogens for imaging and therapy

Adam, Michael J.; Wilbur, D. Scott

doi:10.1039/b313872k

Cited by 222 publications

(159 citation statements)

References 23 publications

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“…[1]. These reactions have found many uses including: radioactive labeling [2], heavy atom addition for diffraction phasing [3], and structural studies relying on differential reactivity [4], among many others [5][6][7]. Surprisingly, iodination in proteins occurs with a greater degree of selectivity than one might expect and preferentially occurs at tyrosine residues, which can be singly or doubly iodinated, as shown in Scheme 1.…”

mentioning

confidence: 99%

Deciphering the peptide iodination code: Influence on subsequent gas-phase radical generation with photodissociation ESI-MS

Liu

Julian

2009

J. Am. Soc. Mass Spectrom.

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Iodination of tyrosine was recently discovered as a useful method for generating radical peptides via photodissociation of carbon-iodine bonds by an ultraviolet photon in the gas phase. The subsequent fragmentation behavior of the resulting odd-electron peptides is largely controlled by the radical. Although previous experiments have focused on mono-iodination of tyrosine, peptides and proteins can also be multiply iodinated. Tyrosine and, to a lesser extent, histidine can both be iodinated or doubly iodinated. The behavior of doubly iodinated residues is explored under conditions where the sites of iodination are carefully controlled. It is found that radical peptides generated by the loss of a single iodine from doubly iodinated tyrosine behave effectively identically to singly iodinated peptides. This suggests that the remaining iodine does not interfere with radical directed dissociation pathways. In contrast, the concerted loss of two iodines from doubly iodinated peptides yields substantially different results that suggest that radical recombination can occur. However, sequential activation can be used to generate multiple usable radicals in different steps of an MS n experiment. Furthermore, it is demonstrated that in actual peptides, the rate of iodination for tyrosine versus monoiodotyrosine cannot be predicted easily a priori. In other words, previous assumptions that mono-iodination of tyrosine is the rate-limiting step to the formation of doubly iodinated tyrosine are incorrect. (J Am Soc Mass Spectrom 2009, 20, 965-971)

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confidence: 99%

Deciphering the peptide iodination code: Influence on subsequent gas-phase radical generation with photodissociation ESI-MS

Liu

Julian

2009

J. Am. Soc. Mass Spectrom.

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“…Administered dose is usually calculated with the goal of administering approximately 70-120 Gy (7000-12000 rad) to the thyroid gland [4]. The calculation is made as follows: administered microcuries = μCi/g desired × gland weight (g) × 100 ÷ percent uptake (24 hours).…”

Section: Discussionmentioning

confidence: 99%

“…On the deep aspect of the thyroid lie the larynx and trachea, with the pharynx and oesophagus behind and the carotid sheath on either side. Two nerves lie in close relationship to the gland; in the groove between the trachea and oesophagus lies the recurrent laryngeal nerve and deep to the upper pole lies the external branch of the superior laryngeal nerve passing to the cricothyroid muscle [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Radioactive Iodine Treatment in Hyperthyroidism Sudanese Patients

2015

IJSR

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Hyperthyroidism is considered as one of common pathological problem associated with thyroid gland, in which thyroid hormone level were increased. This a prospective study attended to assess the role of thyroid ablation using I-131 in treatment of hyperthyroidism in Sudanese population, A 120 patient were treated by using of I 131 at radiation and isotopes center of Khartoum in period from 2012 to 2014. Imaging procedure was done using Tc 99m radiopharmaceutical where the Tc 99m / Mo 99m Generator was used to produce Tc 99m , dose caliber and Dual head Gama camera was used to scan these patient. The level of thyroid hormone were recorded before, and after 3, 6, 9, and 12 month after treatment in order to assess the decrement level of these hormone and therefore performing a quantitative assessment of hyperthyroidism treatment, the result showed that the mean value of these hormones was 6.9, 4.2, 2.8, and 2.5 (nmol/L) for T3, 222.1, 134, 119, 119.2 and 113.4 (nmol/L) for T4, and 0.37, 6.34, 5.3, 2.8, and 2.3 (nmol/L) for TSH respectively. Pair sample two tailed test was performed; a significant difference between the thyroid hormone level was noted before the RAI treatment and after 3, 6, 9, and 12 month later after the treatment, at Confidence level of (CL=95%) and (p value= 0.05), the test were significant at P= 0.000. Causative disease of hyperthyroid function found to be due to Graves' disease in 45 patient (54%) of the collected samples, 28 (23.3%) by TMNG, 30 (25%) due to Diffuse toxic goiter and 6.7% related to the autonomous toxic nodules. This study concludes the hyperthyroidism treatment using I 131 considered effective and cause significant difference in thyroid hormone level after treatment.

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“…This is due to the remarkable physical properties of several iodine radioisotopes (e.g., 125 I, 123 I, 124 I, and 131 I), which allow a broad range of applications from biochemical research to nuclear medicine. 1 For the radioiodination of compounds with no aromatic group or that are sensitive to radiolabeling conditions, the most useful technique remains the use of iodine-containing prosthetic groups. Accordingly, a variety of radioiodinated bifunctional agents have been developed that exploit conjugation strategies such as acylation, hydrazone, imidate, or carbamate formation or thiol alkylation.…”

Section: I]/[mentioning

confidence: 99%

“…It should be noted that this radioisotope was used as a radiolabeling model for iodine-131 (t 1 18 F]FIB-PRGD 2 , respectively. For these reactions, carried out in mild conditions, many parameters were optimized, such as the pH, the temperature and duration of reaction, the total volume of solvent, and the ratio between the volumes of acetonitrile (TFIB) and buffer (peptide).…”

Section: I]/[mentioning

confidence: 99%

Development and Preliminary Evaluation of TFIB, a New Bimodal Prosthetic Group for Bioactive Molecule Labeling

Billaud

Vidal

Vincenot

et al. 2014

ACS Med. Chem. Lett.

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ABSTRACT:The new readily available prosthetic group, tetrafluorophenyl 4-fluoro-3-iodobenzoate (TFIB), designed for both molecular imaging and targeted radionuclide therapy purposes was radiolabeled either with fluorine or iodine radionuclides with excellent radiochemical yields and purities. These radiolabeled tags were conjugated to N,N-diethylethylenediamine to give melanin-targeting radiotracers [

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Radiohalogens for imaging and therapy

Cited by 222 publications

References 23 publications

Deciphering the peptide iodination code: Influence on subsequent gas-phase radical generation with photodissociation ESI-MS

Deciphering the peptide iodination code: Influence on subsequent gas-phase radical generation with photodissociation ESI-MS

Assessment of Radioactive Iodine Treatment in Hyperthyroidism Sudanese Patients

Development and Preliminary Evaluation of TFIB, a New Bimodal Prosthetic Group for Bioactive Molecule Labeling

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