Radioguided Localization of Clinically Occult Breast Lesions (ROLL): A Pilot Study

Abstract

Management of nonpalpable breast lesions requiring pathologic diagnosis has been with wire localization during the last few decades. Recently, radioguided localization (ROLL) became an alternative for this type of lesions. The objective of the present study was to evaluate the feasibility of this technique in a tertiary referral center in Mexico City. Consecutive patients requiring pathologic diagnosis from a nonpalpable breast lesion were included in the present study. On the same day of operation, all patients were injected with particles of human serum albumin. Localization of the lesion was performed in the operation theater with the aid of a hand-held gamma-probe. All lesions were identified in a control x-ray of the surgical specimen. Demographic, clinical, surgical and pathologic data were recorded. Forty patients with a mean age of 56.8 +/- 7.8 years were included. In 39 of the 40 patients (97.5%) the "hot spot" was identified easily. In all patients, the area of maximum radioactivity corresponded to the site of the lesion. Imaging confirmation of the lesion in the surgical specimen was done during the first excision in 37 patients (92.5%). In the remaining cases (7.5%), a wider excision was performed during the same procedure, finding the suspected lesion in all cases. Diagnosis of cancer was made in seven patients, (17.5%). There were no significant surgical complications. Our data suggest that ROLL offer a simple and reliable method to localize occult breast lesions, allowing complete removal of the lesion in 100% of the patients. Because of the small quantity of radioactivity, the procedure is safe for both patients and the medical staff, producing less discomfort in patients than wire localization.

Radioguided occult lesion localization (ROLL) versus wire‐guided lumpectomy for non‐palpable breast lesions: A randomized prospective evaluation

“…After a learning curve with 40 cases enrolled in a pilot study of radioguided localization of breast lesions at our institution [7], we started an IRB approved, randomized, controlled trial comparing this technique with WL. From April 2005 through December 2006, 100 consecutive women with undiagnosed non-palpable breast lesions were prospectively randomized to radioguided occult lesion localization (ROLL) or WL.…”

Radio-guided occult lesion localisation for breast lesions under computer-aided MRI guidance: the first experience and initial results

“…Since its first description in 1996 at the European Institute of Oncology in Milan [20], this technique has allowed easier, more accurate and more rapid removal of such breast lesions than wire localisation [15,18,[21][22][23][24][25]. We adopted ROLL in our centre in December 2004, and since then we have employed this technique under mammography or ultrasonography guidance in approximately 360 patients [18].…”

Radioactive Seed Localization of Breast Lesions: An Adequate Localization Method without Seed Migration

“…For the excision of nonpalpable lesions, a preoperative localization by the radiologist is essential. Preoperative localization of breast cancer is typically performed using wire-guided localization (WGL) or using the radioguided occult lesion localization (ROLL) technique (5)(6)(7)(8)(9)(10)(11)(12). In WGL, one or multiple wires are placed in or surrounding the lesion to serve as a guiding tool for the surgeon.…”