Radiographic texture analysis of densitometer-generated calcaneus images differentiates postmenopausal women with and without fractures

Vokes, Tamara; Giger, Maryellen L.; Chinander, Michael R.; Karrison, Theodore; Favus, Murray J.; Dixon, Larry

doi:10.1007/s00198-006-0089-y

Cited by 43 publications

(35 citation statements)

References 53 publications

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“…In another study including 900 postmenopausal osteoporotic women, texture analysis of the calcaneus differentiated patients with and without prevalent vertebral fracture [13]. Fractal analysis of the calcaneus is also significantly correlated to bone strength evaluated by axial compression testing [14].…”

Section: Introductionmentioning

confidence: 99%

Bone texture analysis of human femurs using a new device (BMA™) improves failure load prediction

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Bone texture analysis of human femurs using a new device (BMA™) improves failure load prediction

et al. 2011

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“…While BMD can be readily measured by dual-energy X-ray absorptiometry (DXA), the technologies used to determine skeletal microarchitecture, such as histomorphometric analysis and micro-computed tomography (µCT) of the transiliac crest bone biopsy (2,3), high resolution peripheral quantitative computed tomography (HRpQCT) (4), and magnetic resonance imaging (MRI) (5) are not routinely available. To this end, and based upon previous studies using 2D X-ray images to estimate bone microstructure (6)(7)(8), the trabecular bone score (TBS), a new approach for assessing skeletal microarchitecture from 2D DXA images (9)(10)(11), has been developed.…”

Section: Introductionmentioning

confidence: 99%

Trabecular bone score: perspectives of an imaging technology coming of age

Silva

Bilezikian

2014

Arq Bras Endocrinol Metab

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The trabecular bone score (TBS) is a new method to describe skeletal microarchitecture from the dual energy X-ray absorptiometry (DXA) image of the lumbar spine. While TBS is not a direct physical measurement of trabecular microarchitecture, it correlates with micro-computed tomography (µCT) measures of bone volume fraction, connectivity density, trabecular number, and trabecular separation, and with vertebral mechanical behavior in ex vivo studies. In human subjects, TBS has been shown to be associated with trabecular microarchitecture and bone strength by high resolution peripheral quantitative computed tomography (HRpQCT). Cross--sectional and prospective studies, involving a large number of subjects, have both shown that TBS is associated with vertebral, femoral neck, and other types of osteoporotic fractures in postmenopausal women. Data in men, while much less extensive, show similar findings. TBS is also associated with fragility fractures in subjects with secondary causes of osteoporosis, and preliminary data suggest that TBS might improve fracture prediction when incorporated in the fracture risk assessment system known as FRAX. In this article, we review recent advances that have helped to establish this new imaging technology. Arq Bras Endocrinol Metab. 2014;58(5):493-503 Keywords Trabecular bone score; osteoporosis; fracture risk; bone mineral density; microarchitecture RESUMO TBS (do inglês, "trabecular bone score") é um novo método que estima a microarquitetura óssea a partir de uma imagem de densitometria óssea (DXA) da coluna lombar. Apesar de o TBS não ser uma medida física direta da microarquitetura trabecular, ele correlaciona-se com o volume ósseo, densidade da conectividade trabecular, número de trabéculas e separação trabecular medidos por microtomografia computadorizada (µCT), e com medidas mecânicas da resistência óssea vertebral em estudos ex vivo. Estudos em humanos confirmaram que o TBS associa-se a microarquitetura trabecular e resistência óssea medidas por tomografia computadorizada quantitativa periférica de alta resolução (HRpQCT). Estudos transversais e prospectivos, envolvendo um grande número de indivíduos, mostraram que o TBS é associado com fratura vertebral, de colo de fêmur e com outros tipos de fraturas osteoporóticas em mulheres na pós-menopausa. Dados em homens, apesar de escassos, mostram resultados semelhantes. Além disso, o TBS foi associado a fraturas por fragilidade em indivíduos com diversas causas secundárias de osteoporose e, dados preliminares, sugerem que o uso do TBS pode melhorar a previsão de fratura quando incorporado ao sistema de avaliação de risco de fratura (FRAX). Este artigo faz uma revisão de avanços recentes que têm ajudado a estabelecer esse novo mé-todo de imagem. Arq Bras Endocrinol Metab. 2014;58(5):493-503 Descritores

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“…However, the greatest and well recognized limitation of bone quantity measurement is the considerable overlap of BMD values in patients with and without fractures [44]; this behavior was ascribed to the contribution of multiple structural determinants to bone strength that are enclosed in the general concept of "bone quality", including bone microarchitecture and bone geometry [45][46][47][48][49][50][51][52][53][54].…”

Section: Discussionmentioning

confidence: 99%

The Role of Trabecular Bone Score and Hip Geometry in Thalassemia Major: A Neural Network Analysis

Baldini¹,

Grossi²,

Cappellini³

et al. 2017

Br J Res

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Osteopathy in thalassemia is a very heterogeneous condition; severity depends on multiple factors, interacting through nonlinear mechanisms. Classic statistics have limitations when applied to the study of such highly complex relationships. Currently, an alternative approach of analysis is represented by the artificial neural networks (ANNs), powerful mathematical tools, increasingly applied to analyze multifactorial databases, as considered more appropriate than classic statistics. We adopted this specialized mathematical method to 76 thalassemia major (TM) patients. In all of them dual energy X-ray absorptiometry (DXA) was performed to measure bone mineral density, and two recent developments were included: trabecular bone score, evaluating bone microarchitecture, and hip structural analysis, evaluating hip geometry. The relationships between bone status and endocrine, hematologic, and clinical parameters were investigated. Using a particular ANN (Auto Contractive Map algorithm), the strength of inter-variable association was defined and a connectivity map generated, visually representing the main connections among the entered variables. Iron status indices (ferritin, liver iron concentration) emerged as the most important variables, dividing the map into two sectors, with parameters indicating satisfactory bone condition in the upper, those indicating poor condition in the lower, near the variable "fractures". The Auto Contractive Map highlighted the key role of bone quantity, bone geometry, and microarchitecture in defining thalassemic bone condition. Among numerous available indices, high femoral bone mineral density and low cross-sectional moment of inertia emerged as the gold standard to classify thalassemic patients for prognostic and therapeutic purposes.

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Radiographic texture analysis of densitometer-generated calcaneus images differentiates postmenopausal women with and without fractures

Abstract: This study suggests that RTA of densitometer-generated calcaneus images provides an estimate of bone fragility independent of and complementary to BMD measurement and age.

Cited by 43 publications

References 53 publications

Bone texture analysis of human femurs using a new device (BMA™) improves failure load prediction

Bone texture analysis of human femurs using a new device (BMA™) improves failure load prediction

Trabecular bone score: perspectives of an imaging technology coming of age

The Role of Trabecular Bone Score and Hip Geometry in Thalassemia Major: A Neural Network Analysis

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