Radiographic Follow-Up during Orthodontic Treatment for Early Diagnosis of Sequential Supernumerary Teeth

Suga, Selma Sano; Kruly, Paula de Castro; Garrido, Talissa Mayer; Matumoto, Marise Sano Suga; Suga, Uhana Seifert Guimarães; Terada, Raquel Sano Suga

doi:10.1155/2016/3067106

Cited by 4 publications

(4 citation statements)

References 10 publications

(21 reference statements)

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“…Dental anomalies, such as extra teeth, impacted teeth, congenital missing teeth, cementum hyperplasia, dental cysts and odontogenic tumours, are noted in 70% of Gardner syndrome individuals. Till now, there are many clinical reports about supernumerary teeth [27][28][29][30]. But the disease pathogenesis is still unclear.…”

Section: Discussionmentioning

confidence: 99%

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A novel mutation of adenomatous polyposis coli (APC) gene results in the formation of supernumerary teeth

Cai

Jiang

et al. 2017

J Cellular Molecular Medi

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Supernumerary teeth are teeth that are present in addition to normal teeth. Although several hypotheses and some molecular signalling pathways explain the formation of supernumerary teeth, but their exact disease pathogenesis is unknown. To study the molecular mechanisms of supernumerary tooth‐related syndrome (Gardner syndrome), a deeper understanding of the aetiology of supernumerary teeth and the associated syndrome is needed, with the goal of inhibiting disease inheritance via prenatal diagnosis. We recruited a Chinese family with Gardner syndrome. Haematoxylin and eosin staining of supernumerary teeth and colonic polyp lesion biopsies revealed that these patients exhibited significant pathological characteristics. APC gene mutations were detected by PCR and direct sequencing. We revealed the pathological pathway involved in human supernumerary tooth development and the mouse tooth germ development expression profile by RNA sequencing (RNA‐seq). Sequencing analysis revealed that an APC gene mutation in exon 15, namely 4292‐4293‐Del GA, caused Gardner syndrome in this family. This mutation not only initiated the various manifestations typical of Gardner syndrome but also resulted in odontoma and supernumerary teeth in this case. Furthermore, RNA‐seq analysis of human supernumerary teeth suggests that the APC gene is the key gene involved in the development of supernumerary teeth in humans. The mouse tooth germ development expression profile shows that the APC gene plays an important role in tooth germ development. We identified a new mutation in the APC gene that results in supernumerary teeth in association with Gardner syndrome. This information may shed light on the molecular pathogenesis of supernumerary teeth. Gene‐based diagnosis and gene therapy for supernumerary teeth may become available in the future, and our study provides a high‐resolution reference for treating other syndromes associated with supernumerary teeth.

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Section: Discussionmentioning

confidence: 99%

“…Till now, there are many clinical reports about supernumerary teeth . But the disease pathogenesis is still unclear.…”

Section: Discussionmentioning

confidence: 99%

A novel mutation of adenomatous polyposis coli (APC) gene results in the formation of supernumerary teeth

Cai

Jiang

et al. 2017

J Cellular Molecular Medi

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“…Among postpermanent supernumeraries, the premolars have received special attention due to their late development and recurrence rate. The first calcifications of supernumerary premolars have been found in adolescence, between ages 12 and 16, as an incidental radiographic finding related to the beginning of an orthodontic treatment (6)(7)(8). The third premolars show an approximate prevalence of 9% with respect of all supernumerary teeth, in addition to be more frequently located in the mandible (1,9).…”

Section: Introductionmentioning

confidence: 99%

Intervention for Multiple Supernumerary Premolars in a Teenager: Case Report

López-Santacruz

Garrigós-Esparza

Fierro-Serna

et al. 2020

Odovtos - Int J Dent Sc

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Supernumerary premolars have received special attention due to their development during adolescence, representing a dental anomaly of number that could be attributed to a “third dentition” of human species. The goal of its treatment is to avoid possible interference in occlusal development, as long as the benefits of supernumerary removal outweigh its risks. This is a case report of the orthodontic and surgical management of a patient that has been in clinical and radiographic follow-up along eight years (since childhood through adolescence) with the emergence of non-syndromic multiple supernumerary premolars, showing an apparent familiar pattern.

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“…Late-developing supernumeraries are those extra teeth that form after normal corresponding teeth of the same region have completed their root formation [7]. In a several reports of late-developing supernumerary teeth, they were mostly found in the mandibular premolar region [2,5,6,9,11,14,17]. Their prevalence in an orthodontic population has been reported to be 0.64% [10].…”

Section: Introductionmentioning

confidence: 99%

Late development of multiple supernumerary teeth in a patient with hypodontia

Stefański¹,

Postek−Stefańska²,

Iwanecka-Zduńczyk³

2019

jos

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A B S T R AC THypo-hyperdontia is a very rare condition in which dental agenesis and supernumerary tooth (or teeth) occur concomitantly. The present case report describes late-forming multiple supernumerary teeth in all quadrants in a nonsyndromic boy with a radiographic diagnosis of mandibular incisor hypodontia made when the patient was 9 years of age. Developing supernumeraries were detected after uneventful orthodontic treatment using fixed appliances on a panoramic radiograph taken shortly after debonding at the age of 15. Cone beam computed tomography was performed to determine the exact location of the extra teeth relative to normal dentition and identify possible root resorption. To the best knowledge of the authors, this is the first reported case of late-developing supernumeraries being a part of the hypo-hyperdontia condition. In conclusion, general dental practitioners should be aware of the rare possibility that a generally healthy individual may develop multiple supernumerary teeth even with the previous diagnosis of hypodontia.

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Radiographic Follow-Up during Orthodontic Treatment for Early Diagnosis of Sequential Supernumerary Teeth

Cited by 4 publications

References 10 publications

A novel mutation of adenomatous polyposis coli (APC) gene results in the formation of supernumerary teeth

A novel mutation of adenomatous polyposis coli (APC) gene results in the formation of supernumerary teeth

Intervention for Multiple Supernumerary Premolars in a Teenager: Case Report

Late development of multiple supernumerary teeth in a patient with hypodontia

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