Radiographic findings in Langerhans' cell disease affecting the mandible

Yu, Qing; Pz, Wang; Hm, Shi; Wang, L; Dx, Sun

doi:10.1016/s1079-2104(05)80292-6

Cited by 9 publications

(4 citation statements)

References 8 publications

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“…Histologically, our case demonstrated all the classical features of eosinophilic granuloma reported in the literature [9] like histiocyte proliferation, presence of multi-nucleated giant cells and eosinophils in loosely arranged fibrous connective tissue.…”

Section: Discussionsupporting

confidence: 74%

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Multifocal Eosinophilic Granuloma of Jaws and Skull with Classical and Unusual Radiographic/Imaging Findings

Raviraj¹

2017

JCDR

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A 37-year-old male patient reported with a chief complaint of loosening of teeth in lower front teeth region since three years. Patient gave a history of trauma to the left skull and left mandibular body region five years back in a road traffic accident. Following the trauma patient did not observe any changes related to his medical and dental health. Patient underwent extraction of teeth no #36,37 due to mobility four months back. The rest of the missing teeth i.e., teeth no #25,26,35,43,45,46 got exfoliated a year back. Patient's past medical history was non-contributory. Extraoral examination revealed no abnormality. Intraoral examination revealed flattening of mandibular left and right posterior alveolar ridges with unhealed sockets in mandibular left posterior region. The gingiva and other mucosal areas did not exhibit any abnormalities. The mucosa covering the residual ridges of mandible appeared as if it was ulcerated due to unhealed sockets in the missing teeth in mandibular left posterior region [Table/ Fig-1a]. On palpating the lingual aspect of mandibular left posterior region a bony hard swelling was appreciable, which corresponded to the periosteal reaction in the occlusal radiograph. The residual ridge of mandibular right posterior region appeared to be flattened. However, the mucosa covering the same appeared normal [ Table/ Eosinophilic granuloma is basically a disorder of reticuloendothelial system and is one of the variants of langerhans cell histiocytosis. Multifocal eosinophilic granuloma affecting jaws and skull is relatively a rare disorder. We hereby report a case of multifocal eosinophilic granuloma involving mandible, maxilla and several skull bones. The present case has mixture of classical floating teeth appearance and an unusual radiographic/imaging finding of periosteal remodeling, which is rarely seen in adult patients of eosinophilic granuloma and pseudo-multilocular appearance in anterior mandibular region in coronal sections and moth-eaten appearance of skull was appreciated in axial slices of Computed Tomography (CT).[

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Section: Discussionsupporting

confidence: 74%

“…Periosteal reactions provide an indication of Biologic activity, usually observed in young children and young adults [9]. A periosteal reaction was observed in the present case in lingual aspect of left mandibular posterior region which is an unusual finding in eosinophilic granuloma for a middle-aged adult.…”

Section: Discussionsupporting

confidence: 61%

Multifocal Eosinophilic Granuloma of Jaws and Skull with Classical and Unusual Radiographic/Imaging Findings

Raviraj¹

2017

JCDR

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“…When associated with the root apices can give the appearance known as ‘floating teeth’. This is due to the replacement of alveolar bone by the Langerhans cell lesion.…”

Section: Discussionmentioning

confidence: 99%

Langerhans cell histiocytosis: an unusual cause of tooth mobility

2014

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Langerhans cell histiocytosis (formerly known as histiocytosis X) is a rare disease of unknown pathogenesis characterised by a pathological proliferation of immature Langerhan cells (important components of the immune response, functioning as antigen presenting cells). Clinical presentation can range from a solitary lesion of bone to a multisystem life‐threatening disorder. Oral manifestations of Langerhans cell histiocytosis have been reported to be as high as 77%. Dentists may be the first clinicians to see early manifestations of the disease. Failure to recognise and appropriately refer these patients could result in extensive destruction of involved tissue, or delay management of the more serious multiorgan disease. We report a case of localised Langerhans cell histiocytosis in a 47‐year‐old female presenting with a short history of single tooth mobility. The clinical and radiographic evaluation, differential diagnosis and management are reported.

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“…There may be severe alveolar bone resorption, producing the appearance of teeth ‘floating in space’ 12 . The radiographic findings of the lesion must be based on bone erosions, marginal changes, periosteal reactions, effects on teeth and pathological fractures 16 .…”

Section: Introductionmentioning

confidence: 99%