Radiographic evidence of disuse osteoporosis in the monkey (M. nemestrina)

Young, Donald R.; Schneider, Victors

doi:10.1007/bf02409501

Cited by 26 publications

(18 citation statements)

References 12 publications

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“…However, since caging arrangements differed among these animals and since disuse osteopenia may be induced in macaques (Shock et al, 1975;Cann et al, 1980;Young and Schneider, 1981), variation in activity levels could have contributed to the bone loss reported.…”

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confidence: 73%

Aging in the musculoskeletal system of rhesus monkeys: III. Bone loss

DeRousseau

1985

American J Phys Anthropol

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It is well established that aging of the human skeleton includes the loss of bone mass or density, but little comparative information on age-related osteopenia in other primates is available. In order to determine whether bone loss occurs in normally locomoting nonhuman primates, radiographs of 139 rhesus monkey skeletons from the Cayo Santiago collection were examined, and measures of percent cortical bone (PCT) at the midshaft of second metacarpals, humeri, and femora were calculated. An age-related osteopenia was observed in the metacarpal of adult female macaques, although much individual variation was present. This variability could not be explained by reproductive history (number of offspring), matrilineal affiliation, or degree of osteoarthrosis. However, in a subsample of 15 animals, females who had given birth in the three months prior to death showed lower PCTs than those who had not conceived in the previous mating season. In adult males, PCT did not vary significantly with age, but males that weighed less and those with no/little osteoarthrosis showed lower PCTs than heavier or more arthritic animals, respectively. The multifactorial nature of the variation in PCT observed here suggests that similar processes of bone behavior are involved in the skeletal aging of both humans and rhesus monkeys.

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confidence: 73%

Aging in the musculoskeletal system of rhesus monkeys: III. Bone loss

DeRousseau

1985

American J Phys Anthropol

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“…Both osteoid volume and apposition rate are reduced (Whedon, 1960;Landry and Fleisch, 1964;Minaire et al, 1974;Schock et al, 1975;Morey and Baylink, 1978;Young and Schneider, 1981;Simmons, 1981). The effect of a reduced bone-formation rate in individual BMUs can be exacerbated by a significant increase in activation rate.…”

Section: At E N D O S T E a L -Loss At H A V E R S I A N Surface Surfmentioning

confidence: 95%

Errors in bone remodeling: Toward a unified theory of metabolic bone disease

1989

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Recent evidence suggests that skeletal adaptation is organized by a functional unit that includes cells of diverse origin working in coordination. Genetic and metabolic factors control and regulate the processes of modeling and remodeling, only rarely acting on the isolated individual functions of specific cell lines. Errors in the genetic or metabolic regulation of the functional unit affect the entire process of skeletal adaptation rather than specific elements of it. Viewed in this way, some metabolic bone diseases can be understood as relatively simple errors in factors that control the coordinated activities of the entire functional unit. This paper reviews the modeling and remodeling processes and demonstrates how abnormal morphological characteristics of bone tissue can be viewed as products of specific errors in the adaptive process.

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“…In an earlier study based on radiography and in vivo tomography [6], we concluded that osteopenia in the tibia was associated with reductions of bone mineral and bone mass per unit length of bone as well as per unit thickness of cortical bone. The demonstration of large resorption cavities in the cortex now documents that bone loss is related to a significant increase in bone resorption.…”

Section: Discussionmentioning

confidence: 91%

“…Studies in our laboratory have also shown characteristic losses of tibial cortical bone in restrained hypodynamic monkeys [6]. Radiographically, disuse os-The short-term studies were performed with 7 male adult rhesus (M. mulatta) monkeys, restrained for periods of 3 5 weeks.…”

Section: Methodsmentioning

confidence: 99%

Tibial changes in experimental disuse osteoporosis in the monkey

1983

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We studied the mechanical properties and structural changes in the monkey tibia with disuse osteoporosis and during subsequent recovery. Bone bending stiffness was evaluated in relationship to microscopic changes in cortical bone and Norland bone mineral analysis. Restraint in the semireclined position produced regional losses of bone most obviously in the anterior-proximal tibiae. Following 6 months of restraint, the greatest losses of bone mineral in the proximal tibiae ranged from 23% to 31%; the largest changes in bone stiffness ranged from 36% to 40%. Approximately 8 1/2 months of recovery were required for restoration of normal bending properties. However, even after 15 months of recovery, bone mineral content did not necessarily return to normal levels. Histologically, resorption cavities in cortical bone were seen within 1 month of restraint; by 2 1/2 months of restraint there were large resorption cavities subperiosteally, endosteally, and intracortically. After 15 months of recovery, the cortex consisted mainly of first-generation haversian systems. After 40 months, the cortex appeared normal with numerous secondary and tertiary generations of haversian systems.

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Radiographic evidence of disuse osteoporosis in the monkey (M. nemestrina)

Cited by 26 publications

References 12 publications

Aging in the musculoskeletal system of rhesus monkeys: III. Bone loss

Aging in the musculoskeletal system of rhesus monkeys: III. Bone loss

Errors in bone remodeling: Toward a unified theory of metabolic bone disease

Tibial changes in experimental disuse osteoporosis in the monkey

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