Radiographic-Clinical Correlation in Severe Acute Respiratory Syndrome: Study of 1373 Patients in Hong Kong

Antonio, Gregory E.; Ooi, Clara G. C.; Wong, Kin Fai Ellick; Tsui, Eva L. H.; Wong, Janus Siu Him; Sy, Alan N L; Hui, Joyce Y. H.; Chan, C Y; Huang, Henry Y H; Chan, Yip Fai; Wong, Tai Pang; Leong, Lilian; Chan, James C.; Ahuja, Anil T.

doi:10.1148/radiol.2373041919

Cited by 35 publications

(32 citation statements)

References 26 publications

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“…The maximal radiographic score correlated best with the percentage of lymphocytes in a leukocyte count, followed by the number of hospitalized days and the absolute lymphocyte count.. The above findings were somewhat different from findings in other series (27, 29, 32, 38). …”

Section: Discussioncontrasting

confidence: 58%

“…Three of the 28 patients expired with a mortality rate of 10.7%, which is comparable to that seen overall in Taiwan (12.3%), Hong Kong (11.7%), and worldwide (9.6%) (4, 27). It has been reported that for patients with SARS, old age and comorbities are more likely to be associated with a high mortality (17-20).…”

Section: Discussionsupporting

confidence: 51%

“…These factors include the severity of hypoxemia and platelet count (17, 38), an age over 60 years and elevated LDH (18, 20), comorbidities (19, 27, 38), and a high neutrophil count on admission (20). Poor prognostic factors for SARS in radiological findings comprise the number of involved lobes during the acute phase, multifocal opacities with progression to diffuse airspaces opacification or an initial radiographic presentation with multifocal or diffuse airspaces opacities (17, 30-32, 38).…”

Section: Discussionmentioning

confidence: 99%

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A Correlation between the Severity of Lung Lesions on Radiographs and Clinical Findings in Patients with Severe Acute Respiratory Syndrome

et al. 2007

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ObjectiveThe purpose of this study was to quantify lesions on chest radiographs in patients with severe acute respiratory syndrome (SARS) and analyze the severity of the lesions with clinical parameters.Materials and MethodsTwo experienced radiologists reviewed chest radiographs of 28 patients with SARS. Each lung was divided into upper, middle, and lower zones. A SARS-related lesion in each zone was scored using a four-point scale: zero to three. The mean and maximal radiographic scores were analyzed statistically to determine if the scorings were related to the laboratory data and clinical course.ResultsForward stepwise multiple linear regression showed that the mean radiographic score correlated most significantly with the number of hospitalized days (p < 0.001). The second most significant factor was the absolute lymphocyte count (p < 0.001) and the third most significant factor was the number of days of intubation (p = 0.025). The maximal radiographic score correlated best with the percentage of lymphocytes in a leukocyte count (p < 0.001), while the second most significant factor was the number of hospitalized days (p < 0.001) and the third most significant factor was the absolute lymphocyte count (p = 0.013). The mean radiographic scores of the patients who died, with comorbidities and without a comorbidity were 11.1, 6.3 and 2.9, respectively (p = 0.032). The corresponding value for maximal radiographic scores were 17.7, 9.7 and 6.0, respectively (p = 0.033).ConclusionThe severity of abnormalities quantified on chest radiographs in patients with SARS correlates with the clinical parameters.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

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A Correlation between the Severity of Lung Lesions on Radiographs and Clinical Findings in Patients with Severe Acute Respiratory Syndrome

et al. 2007

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“…In this series, only 42% of patients demonstrate positive findings and this is likely due to the range of clinical presentation of the study population. Several studies have a similar initial CXR positive findings of 42-50% for this disease [12, 13]. …”

Section: Discussionmentioning

confidence: 66%

“…Other changes recorded on CT were focal or multifocal consolidation, interstitial changes and pulmonary embolism [4, 13, 14]. CT was valuable in detecting positive findings in the presence of normal CXRs and showed more extensive pattern of involvement when compared to CXR [14].…”

Section: Discussionmentioning

confidence: 99%

Chest imaging features of patients afflicted with Influenza A (H1N1) in a Malaysian tertiary referral centre

Bux¹,

Ramli²,

S³

et al. 2010

Biomed. Imaging Interv. J.

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This is a retrospective descriptive study of the chest imaging findings of 118 patients with confirmed A(H1N1) in a tertiary referral centre. About 42% of the patients had positive initial chest radiographic (CXR) findings. The common findings were bi-basal air-space opacities and perihilar reticular and alveolar infiltrates. In select cases, high-resolution computed tomography (CT) imaging showed ground-glass change with some widespread reticular changes and atelectasis.

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Associations between CT pulmonary opacity score on admission and clinical characteristics and outcomes in patients with COVID-19

et al. 2021

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This study investigated associations between chest computed tomography (CT) pulmonary opacity score on admission and clinical features and outcomes in COVID-19 patients. The retrospective multi-center cohort study included 496 COVID-19 patients in Jiangsu province, China diagnosed as of March 15, 2020. Patients were divided into four groups based on the quartile of pulmonary opacity score: ≤ 5%, 6–20%, 21–40% and 41% +. CT pulmonary opacity score was independently associated with age, single onset, fever, cough, peripheral capillary oxygen saturation, lymphocyte count, platelet count, albumin level, C-reactive protein (CRP) level and fibrinogen level on admission. Patients with score ≥ 41% had a dramatic increased risk of severe or critical illness [odds ratio (OR), 15.58, 95% confidence interval (CI) 3.82–63.53), intensive care unit (ICU)] admission (OR, 6.26, 95% CI 2.15–18.23), respiratory failure (OR, 19.49, 95% CI 4.55–83.40), and a prolonged hospital stay (coefficient, 2.59, 95% CI 0.46–4.72) compared to those with score ≤ 5%. CT pulmonary opacity score on admission, especially when ≥ 41%, was closely related to some clinical characteristics and was an independent predictor of disease severity, ICU admission, respiratory failure and long hospital stay in patients with COVID-19.

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Radiographic-Clinical Correlation in Severe Acute Respiratory Syndrome: Study of 1373 Patients in Hong Kong

Abstract: The initial extent of radiographic opacification may be useful for prognostic prediction. Radiographic progression correlates well with that of important clinical and laboratory parameters and may be used as an objective prognostic indicator early in SARS.

Cited by 35 publications

References 26 publications

A Correlation between the Severity of Lung Lesions on Radiographs and Clinical Findings in Patients with Severe Acute Respiratory Syndrome

A Correlation between the Severity of Lung Lesions on Radiographs and Clinical Findings in Patients with Severe Acute Respiratory Syndrome

Chest imaging features of patients afflicted with Influenza A (H1N1) in a Malaysian tertiary referral centre

Associations between CT pulmonary opacity score on admission and clinical characteristics and outcomes in patients with COVID-19

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