Radiographic assessment of the progression of osteoarthrosis in the contralateral stifle joint of dogs with a ruptured cranial cruciate ligament

Bruin, Tanya de; Rooster, H. de; Bosmans, Tim; Duchateau, Luc; Bree, Henri van; Gielen, Ingrid

doi:10.1136/vr.161.22.745

Cited by 37 publications

(56 citation statements)

References 26 publications

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“…We found Grade 2 effusion was present in a large majority of index stifles, with 40% of index stifles also affected with Grade 3 osteophytosis. Radiographic signs of contralateral stifle OA in dogs with unilateral CR influence risk of contralateral CR, based on global assessment of synovial effusion, osteophytosis, and subchondral sclerosis [6], [9]. However, past analyses have been limited to determining that global scoring of radiographic change, including synovial effusion and osteophytosis, influenced risk of contralateral CR.…”

Section: Discussionmentioning

confidence: 99%

“…Radiographic signs of OA are often present in clinically stable contralateral stifle joints at the time of diagnosis [2], [12], [14], [15], but underestimate severity of synovitis [2]. It has been recognized for some time that radiographic signs of contralateral stifle joint degeneration in dogs with unilateral CR influence risk of contralateral CR [6], [9]. However, these analyses were limited to determining that global scoring of radiographic change, including synovial effusion and osteophytosis, influenced risk of contralateral CR.…”

Section: Introductionmentioning

confidence: 99%

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Radiographic Risk Factors for Contralateral Rupture in Dogs with Unilateral Cranial Cruciate Ligament Rupture

et al. 2014

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BackgroundComplete cranial cruciate ligament rupture (CR) is a common cause of pelvic limb lameness in dogs. Dogs with unilateral CR often develop contralateral CR over time. Although radiographic signs of contralateral stifle joint osteoarthritis (OA) influence risk of subsequent contralateral CR, this risk has not been studied in detail.Methodology/Principal FindingsWe conducted a retrospective longitudinal cohort study of client-owned dogs with unilateral CR to determine how severity of radiographic stifle synovial effusion and osteophytosis influence risk of contralateral CR over time. Detailed survival analysis was performed for a cohort of 85 dogs after case filtering of an initial sample population of 513 dogs. This population was stratified based on radiographic severity of synovial effusion (graded on a scale of 0, 1, and 2) and severity of osteophytosis (graded on a scale of 0, 1, 2, and 3) of both index and contralateral stifle joints using a reproducible scoring method. Severity of osteophytosis in the index and contralateral stifles was significantly correlated. Rupture of the contralateral cranial cruciate ligament was significantly influenced by radiographic OA in both the index and contralateral stifles at diagnosis. Odds ratio for development of contralateral CR in dogs with severe contralateral radiographic stifle effusion was 13.4 at one year after diagnosis and 11.4 at two years. Odds ratio for development of contralateral CR in dogs with severe contralateral osteophytosis was 9.9 at one year after diagnosis. These odds ratios were associated with decreased time to contralateral CR. Breed, age, body weight, gender, and tibial plateau angle did not significantly influence time to contralateral CR.ConclusionSubsequent contralateral CR is significantly influenced by severity of radiographic stifle effusion and osteophytosis in the contralateral stifle, suggesting that synovitis and arthritic joint degeneration are significant factors in the disease mechanism underlying the arthropathy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Radiographic Risk Factors for Contralateral Rupture in Dogs with Unilateral Cranial Cruciate Ligament Rupture

et al. 2014

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“…Bilateral rupture may be diagnosed at initial presentation, or by development of subsequent contralateral CrCLR, often within a relatively short period of time from diagnosis. Risk of subsequent contralateral CrCLR has typically been reported as a proportion at long-term follow-up, often around one year from diagnosis [2], [3], [5]–[7]. This risk is in the range of 22–54% [2], [3], [5]–[7].…”

Section: Discussionmentioning

confidence: 99%

“…Analysis of this risk has usually been reported as an incidence after surgery (percentage of patients within the cohort). This risk is in the range of 22–54% at 6 to 17 months of diagnosis [2], [3], [5]–[7]. One of the limitations of this approach to data analysis is that it yields little information on the pattern of subsequent contralateral rupture.…”

Section: Introductionmentioning

confidence: 99%

Contralateral Cruciate Survival in Dogs with Unilateral Non-Contact Cranial Cruciate Ligament Rupture

et al. 2011

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BackgroundNon-contact cranial cruciate ligament rupture (CrCLR) is an important cause of lameness in client-owned dogs and typically occurs without obvious injury. There is a high incidence of bilateral rupture at presentation or subsequent contralateral rupture in affected dogs. Although stifle synovitis increases risk of contralateral CrCLR, relatively little is known about risk factors for subsequent contralateral rupture, or whether therapeutic intervention may modify this risk.Methodology/Principal FindingsWe conducted a longitudinal study examining survival of the contralateral CrCL in client-owned dogs with unilateral CrCLR in a large baseline control population (n = 380), and a group of dogs that received disease-modifying therapy with arthroscopic lavage, intra-articular hyaluronic acid and oral doxycycline (n = 16), and were followed for one year. Follow-up in treated dogs included analysis of mobility, radiographic evaluation of stifle effusion and arthritis, and quantification of biomarkers of synovial inflammation. We found that median survival of the contralateral CrCL was 947 days. Increasing tibial plateau angle decreased contralateral ligament survival, whereas increasing age at diagnosis increased survival. Contralateral ligament survival was reduced in neutered dogs. Our disease-modifying therapy did not significantly influence contralateral ligament survival. Correlative analysis of clinical and biomarker variables with development of subsequent contralateral rupture revealed few significant results. However, increased expression of T lymphocyte-associated genes in the index unstable stifle at diagnosis was significantly related to development of subsequent non-contact contralateral CrCLR.ConclusionSubsequent contralateral CrCLR is common in client-owned dogs, with a median ligament survival time of 947 days. In this naturally occurring model of non-contact cruciate ligament rupture, cranial tibial translation is preceded by development of synovial inflammation. However, treatment with arthroscopic lavage, intra-articular hyaluronic acid and oral doxycycline does not significantly influence contralateral CrCL survival.

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“…So l ä sst sich, wie in diesem Fall, die L ä sion darstellen, bevor Befunde auf den R ö ntgenbildern sichtbar sind. [8] .…”

Section: Einsatz Der Skelettszintigrafi E In Der Lahmheitsdiagnostik unclassified

Einsatz der Skelettszintigrafie in der Lahmheitsdiagnostik beim Kleintier

Bolln

Franke

2010

Der Nuklearmediziner

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Zusammenfassung Zur Lahmheitsdiagnostik beim Kleintier hat sich die Skelettszintigrafie als geeignete Methode erwiesen. Sie ist eine sensitive, nichtinvasive Methode, um Knochenläsionen darzustellen. Sie ermöglicht eine funktionelle Darstellung des Skeletts und damit eine frühzeitige Lokalisation und Diagnose bei unklaren Lahmheiten. Einer der wesentlichen Unterschiede zur humanmedizinischen Diagnostik ist, dass ein Tier nicht in der Lage ist, die Art seiner Schmerzen dem Untersucher mitzuteilen. Dazu kommt die fehlende Kooperationsbereitschaft des Tieres bei der Durchführung der Szintigrafie. Vor diesem Hintergrund werden anhand von 5 Beispielen die Vorteile, die Durchführbarkeit und die verschiedenen Indikationen für eine Skelettszintigrafie dargestellt. Die Technik der Untersuchung orientiert sich an den humanmedizinischen Protokollen einer 2-Phasen-Skelettszintigrafie und muss in Narkose durchgeführt werden, um Bewegungsartefakte während der Akquisition auszuschließen. Die Autoren sehen die Skelettszintigrafie als sinnvolles Diagnostikum in der Lahmheitsuntersuchung beim Kleintier, welches richtungsweisend für eine schnelle Diagnose und damit gezielte Therapie ist. So können Sekundärschäden und unnötige Kosten für den Besitzer minimiert werden.

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Radiographic assessment of the progression of osteoarthrosis in the contralateral stifle joint of dogs with a ruptured cranial cruciate ligament

Cited by 37 publications

References 26 publications

Radiographic Risk Factors for Contralateral Rupture in Dogs with Unilateral Cranial Cruciate Ligament Rupture

Radiographic Risk Factors for Contralateral Rupture in Dogs with Unilateral Cranial Cruciate Ligament Rupture

Contralateral Cruciate Survival in Dogs with Unilateral Non-Contact Cranial Cruciate Ligament Rupture

Einsatz der Skelettszintigrafie in der Lahmheitsdiagnostik beim Kleintier

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