Radiographic Appearance and Clinical Outcome Correlates in 26 Patients with Severe Acute Respiratory Syndrome

Hsieh, Shu Chiang; Chan, Wing P.; Chien, Jerry Chin Wei; Lee, Wen Sen; Yao, Ming; Choi, Wai M.; Chen, Chia Yuen; Yu, Chun Pong

doi:10.2214/ajr.182.5.1821119

Cited by 13 publications

(14 citation statements)

References 9 publications

(28 reference statements)

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“…At this stage, the lesions show a reduction in the scope of the lesion, a decrease in the density of ground glass or consolidation, and a decrease in CT attenuation. Hsieh et al 20 suggested that SARS lesions in the lungs may vary depending on the patient's physique, treatment, and condition. Some patients absorbed lesions within 3 months, and long-term, patients still had a shadow within 1 year.…”

Section: Discussionmentioning

confidence: 99%

The characteristics and clinical value of chest CT images of novel coronavirus pneumonia

Zhao

Liu

et al. 2020

Clinical Radiology

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AIM: To investigate the characteristics and clinical value of chest computed tomography (CT) images of novel coronavirus pneumonia (NCP).MATERIALS AND METHODS: Clinical data and CT images of 80 cases of NCP were collected. The clinical manifestations and laboratory test results of the patients were analysed. The lesions in each lung segment of the patient's chest CT images were characterised. Lesions were scored according to length and diffusivity.RESULTS: The main clinical manifestations were fever, dry cough, fatigue, a little white sputum, or diarrhoea. A total of 1,702 scored lesions were found in the first chest CT images of 80 patients. The lesions were located mainly in the subpleural area of the lungs (92.4%). Most of the lesions were ground-glass opacity, and subsequent fusions could increase in range and spread mainly in the subpleural area. Pulmonary consolidation accounted for 44.1% of all of the lesions. Of the 80 cases, 76 patients (95%) had bilateral lung disease, four (5%) patients had unilateral lung disease, and eight (10%) patients had cord shadow.CONCLUSION: The chest CT of NCP patients is characterised by the onset of bilateral groundglass lesions located in the subpleural area of the lung, and progressive lesions that result in consolidation with no migratory lesions. Pleural effusions and mediastinal lymphadenopathy are rare. As patients can have inflammatory changes in the lungs alongside a negative early nucleic acid test, chest CT, in combination with epidemiological and laboratory tests, is a useful examination to evaluate the disease and curative effect.

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Section: Discussionmentioning

confidence: 99%

The characteristics and clinical value of chest CT images of novel coronavirus pneumonia

Zhao

Liu

et al. 2020

Clinical Radiology

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“…Past studies demonstrated that HRCT was the most sensitive imaging method for detecting early lung changes in acute pulmonary diseases [7,[9][10][11][12]. Characteristic CT findings in SARS include ground glass opacification or consolidation, thickening of the interlobular or intralobular interstitium, and crazy paving appearance [3,[13][14][15][16][17][18], with a peripheral and lower lobe predominance in the early course of the disease, progressing to diffuse and bilateral involvement in the latter stage [13,15,18]. On the other hand, characteristic CT findings in metapneumovirus infection include patchy areas of ground glass attenuation, small nodules, and multifocal areas of consolidation in a bilateral asymmetrical distribution [4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

Comparison of initial high resolution computed tomography features in viral pneumonia between metapneumovirus infection and severe acute respiratory syndrome

Wong

Lai

Wong

2012

European Journal of Radiology

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“…Chest radiographs typically show ground-glass opacities and focal consolidations, especially in the periphery and subpleural regions of the lower zones. Progressive involvement of both lungs is not uncommon (113,148,184,362). Shifting of radiographic shadows and spontaneous pneumomediastinum may occur (74,258).…”

Section: Clinical Featuresmentioning

confidence: 99%

Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection

et al. 2007

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SUMMARY Before the emergence of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) in 2003, only 12 other animal or human coronaviruses were known. The discovery of this virus was soon followed by the discovery of the civet and bat SARS-CoV and the human coronaviruses NL63 and HKU1. Surveillance of coronaviruses in many animal species has increased the number on the list of coronaviruses to at least 36. The explosive nature of the first SARS epidemic, the high mortality, its transient reemergence a year later, and economic disruptions led to a rush on research of the epidemiological, clinical, pathological, immunological, virological, and other basic scientific aspects of the virus and the disease. This research resulted in over 4,000 publications, only some of the most representative works of which could be reviewed in this article. The marked increase in the understanding of the virus and the disease within such a short time has allowed the development of diagnostic tests, animal models, antivirals, vaccines, and epidemiological and infection control measures, which could prove to be useful in randomized control trials if SARS should return. The findings that horseshoe bats are the natural reservoir for SARS-CoV-like virus and that civets are the amplification host highlight the importance of wildlife and biosecurity in farms and wet markets, which can serve as the source and amplification centers for emerging infections.

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Radiographic Appearance and Clinical Outcome Correlates in 26 Patients with Severe Acute Respiratory Syndrome

Abstract: The initial predominant radiographic feature of SARS was air-space consolidation in the lateral and lower lung zones. Progressive deterioration to diffuse unilateral or bilateral consolidation in the series of follow-up chest radiographs is associated with a poor prognosis.

Cited by 13 publications

References 9 publications

The characteristics and clinical value of chest CT images of novel coronavirus pneumonia

The characteristics and clinical value of chest CT images of novel coronavirus pneumonia

Comparison of initial high resolution computed tomography features in viral pneumonia between metapneumovirus infection and severe acute respiratory syndrome

Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection

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