Radiographic abnormalities in carcinoma of the lung as related to histological cell type

Byrd, Richard B.; Carr, David; Miller, W. Eugene; Payne, W. Spencer; Woolner, Lewis B.

doi:10.1136/thx.24.5.573

Cited by 74 publications

(36 citation statements)

References 3 publications

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“…In our study, 80% of the adenocarcinomas occurred peripherally, but only 45% of the SCCs occurred in a central location. Although the relationship between tumor histology and location may have been straightforward in the mid-twentieth century (43,44), more recent studies have described considerable proportions of SCC in a peripheral location (39-59%; refs. [45][46][47] as well as adenocarcinoma in a central location (41-60%; refs.…”

Section: Discussionmentioning

confidence: 99%

Influence of Type of Cigarette on Peripheral versus Central Lung Cancer

Brooks

Austin

Heelan

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Objectives: Adenocarcinoma has replaced squamous cell carcinoma as the most common cell type of lung cancer in the United States. It has been proposed that this shift is due to the increased use of filter and lower-tar cigarettes, resulting in increased delivery of smoke to peripheral regions of the lungs, where adenocarcinoma usually occurs. We reviewed radiologic data to evaluate the hypothesis that tumors in smokers of cigarettes with lower-tar yield are more likely to occur peripherally than tumors in smokers of higher-yield cigarettes. Methods: At two urban academic medical centers, we reviewed computed tomographic scans, chest radiographs, and medical records to assign tumor location (peripheral or central) for 330 smokers diagnosed with carcinoma of the lung between 1993 and 1999. We compared the proportion of tumors in a peripheral versus central location by lifetime filter use and average lifetime tar rating (<21 and z z z21 mg). Results: Tumor location (69% peripheral and 31% central) was unrelated to cigarette filter use. Smokers of cigarettes with lower-tar ratings were more likely than those with higher ratings to have peripheral rather than central tumors (odds ratio, 1.76; 95% confidence interval, 0.89-3.47). When restricted to subjects with adenocarcinoma or squamous cell carcinoma, the odds ratio (95% confidence interval) was 2.31 (1.05-5.08).

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Section: Discussionmentioning

confidence: 99%

Influence of Type of Cigarette on Peripheral versus Central Lung Cancer

Brooks

Austin

Heelan

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In the Mayo Clinic series, 38% of patients with lung cancer had a hila or peri-hila mass [89]. More recently, 14 of 25 patients (56%) with CT performed for an abnormal hilum were found to have bronchogenic carcinoma [90].…”

Section: Central Tumoursmentioning

confidence: 99%

Diagnostic imaging of lung cancer

Hollings¹,

Shaw²

2002

Eur Respir J

121

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Carcinoma of the bronchus is the most common malignancy in the Western world. It is also the leading cause of cancer-related death accounting for 32% of all cancer deaths in males and 25% in females [1]. In the USA it causes more deaths than cancers of the colon, breast and prostate combined [2]. Disappointingly, in a recent UK survey of improvements in cancer survival [3], carcinoma of the bronchus showed the smallest percentage reduction in the number of deaths avoided between 1981-1990 (0.2%). This compares badly with breast (11% reduction) and melanoma (32%). The overall 5-yr survival for lung cancer diagnosed between 1986-1990 was only 5.3% (against 66% for breast and 76% for melanoma). It is on this background that the radiologist remains actively employed in the detection, diagnosis, staging and review of this common malignancy.

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“…@-@ At one time adenocarcinomas were not thought to be related to cigarette smoking, but the relationship is now evi dent, except for bronchioloalveolar carci nomas in women. [7][8][9] The bronchioloalveolar type of adeno carcinoma tends to grow along pre existing alveolar walls. It tends to be a slow-growing, low-grade cancer, but it is capricious in its behavior.…”

Section: Histopathologymentioning

confidence: 99%