Radiogene Karies: Ätiologie und Möglichkeiten der Prävention

Schweyen, Ramona; Hey, Jeremias; Fränzel, Wolfgang; Vordermark, Dirk; Hildebrandt, G; Kuhnt, Thomas

doi:10.1007/s00066-011-0011-1

Cited by 15 publications

(9 citation statements)

References 51 publications

(69 reference statements)

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“…Indirect effects of radiotherapy—including changes in salivary quantity and composition, together with alteration of the oral flora—are widely regarded as the major causes of radiation caries [8, 9]. However, these factors could not well explain the characteristic features of radiation caries, such as the initial loss of cervical and incisal enamel.…”

Section: Introductionmentioning

confidence: 99%

Direct radiation-induced effects on dental hard tissue

Zhao

Guo

et al. 2019

Radiat Oncol

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BackgroundRadiation caries is a complication of radiotherapy characterized by enamel erosion and dentin exposure. The mechanisms of characteristic radiation caries formation are not well-understood. The aim of this study was to evaluate the direct radiation-induced effects on dental hard tissue and investigate their role in the formation of radiation caries.MethodsSixty non-carious third molars were divided into three groups (n = 20), which would be exposed to 0 Gy, 30 Gy, and 60 Gy radiation, respectively. After radiation, microhardness and elastic modulus were measured at four depths by means of a Vickers microhardness tester and atomic force microscopy (AFM). The microstructure was observed by scanning electron microscopy (SEM). X-ray diffraction and Raman microspectroscopy were used to determine crystal properties and protein/mineral (2931/960 cm− 1) ratios.ResultsA statistically significant decrease in microhardness and elastic modulus values 50 μm from the dentino-enamel junction (DEJ) in enamel was revealed in the 30-Gy and 60-Gy groups. With the increasing dose, destruction of interprismatic substance and fissures at the DEJ-adjacent region were found. A greater reduction of crystallinity was revealed in enamel compared with dentin. Raman spectroscopic analysis showed a slight increase of the protein/mineral ratio for enamel following accumulated radiation, while the protein/mineral ratio for dentin was decreased.ConclusionsRadiation could directly alter the mechanical properties, micro-morphology, crystal properties, and chemical composition of dental hard tissue. The early destruction of DEJ-adjacent enamel, combined with decreased crystallinity of enamel under radiation exposure, may be related to the formation of characteristic radiation caries.

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Section: Introductionmentioning

confidence: 99%

Direct radiation-induced effects on dental hard tissue

Zhao

Guo

et al. 2019

Radiat Oncol

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“…Dentinoenamel junction (DEJ) plays an important role in the pathological process of radiation caries. Changes in the amount and composition of saliva are among the major causes of radiation caries [ 9 ]. However, this does not fully explain the causes of enamel fractures.…”

Section: Introductionmentioning

confidence: 99%

Effect of different doses of radiation on morphogical, mechanical and chemical properties of primary and permanent teeth—an in vitro study

2020

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Background: Radiotherapy, applied to the head and neck region, can cause radiation side effects such as reduction of saliva and radiation caries. The aim of this study was to perform an in vitro assessment of the effects of radiation therapy on the morphological, mechanical, and chemical properties of primary and permanent teeth. Methods: One hundred four extracted human teeth (52 impacted wisdom teeth, 52 primary molar teeth) were used. The teeth were divided into two parts in the mesiodistal direction. Of the 98 teeth, the vestibular sections were used for the vickers analysis and lingual sections were used for the Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES) analysis. The teeth in the experimental group were fixed to wax models. Each model had an equal number of teeth (n = 7). The doses were applied to the teeth for 6 weeks; 5 week days and 2Gy daily. After the radiotherapy was conducted weekly, a wax model was taken from radiation reception. Along with the elemental contents (Na, K, Mg, P, and Ca) of the teeth, enamel and dentin microhardness was evaluated, and SEM analyzes were performed on 6 teeth. Results: Radiation caused a decrease in microhardness of enamel and dentin (p < 0.05). In the elemental analysis by ICP-OES, it was observed that there were decreases in all elements after 60Gy compared to the control group (p < 0.05). In the experimental groups, amorphous structures were encountered in SEM images. Conclusions: Radiation has negative effects on the teeth structure and additional studies are needed in this regard. This study indicates that radiotherapy patients are at a higher risk for dental caries.

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“…Changes in the amount and composition of saliva are among the major causes of radiation caries. 9 However, this does not fully explain the causes of enamel fractures. This obscurity has forced researchers to investigate the direct effects of radiation on dental hard tissues.…”

Section: Introductionmentioning

confidence: 98%

The effect of different doses of radiation on the morphogical, mechanical and chemical properties of the primary and permanent teeth—an in vitro study

Duruk

Acar

Temelli

2020

Preprint

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Background. Radiotherapy, applied to the head and neck region, can cause radiation side effects such as reduction of saliva and radiation caries. The aim of this study was to perform an in vitro assessment of the effects of radiation therapy on the morphological, mechanical, and chemical properties of primary and permanent teeth. Methods. 92 extracted human teeth (46 impacted wisdom teeth, 46- primary molar teeth) were used. The teeth were divided into two directions: the mesiodistal direction and the vestibulolingual direction. The vestibular sections were used for vickers analysis, and lingual sections were used for Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES) analysis. The teeth in the experimental group were fixed to wax models. Each model had an equal number of teeth (n=7). The doses were applied to the teeth for 6 weeks; 5 week days and 2Gy daily. After the radiotherapy conducted weekly, a wax model was taken from radiation reception. Along with elemental contents (Ca, P, Na, Mg, P) of the teeth, enamel and dentin microhardness were evaluated, and SEM analyzes were performed on 8 teeth. These teeth were compared with the other non-irradiated sections. Results. Radiation caused a decrease in microhardness of enamel and dentin(p<0.05). In elemental analysis by ICP-OES, it was observed that there were decreases in all doses, while the highest decrease was in 60Gy dose(p<0.01). In the experimental groups, amorphous structures were encountered in SEM images. Conclusions. Radiation has negative effects on the teeth structure and additional studies are needed in this regard. This study indicates that radiotherapy patients are at a higher risk for dental caries

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Radiogene Karies: Ätiologie und Möglichkeiten der Prävention

Abstract: To enable optimal medical care of the patients during the time course of radiotherapy as well as afterwards, close interdisciplinary cooperation between radiotherapists, oral surgeons, otorhinolaryngologists, and dentists is absolutely essential.

Cited by 15 publications

References 51 publications

Direct radiation-induced effects on dental hard tissue

Direct radiation-induced effects on dental hard tissue

Effect of different doses of radiation on morphogical, mechanical and chemical properties of primary and permanent teeth—an in vitro study

The effect of different doses of radiation on the morphogical, mechanical and chemical properties of the primary and permanent teeth—an in vitro study

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