Radiofrequency-Triggered Tumor-Targeting Delivery System for Theranostics Application

Abstract

In this study, a new type of magnetic tumor-targeting PEGylated gold nanoshell drug delivery system (DOX-TSMLs-AuNSs-PEG) based on doxorubicin-loaded thermosensitive magnetoliposomes was successfully obtained. The reverse-phase evaporation method was used to construct the magnetoliposomes, and then gold nanoshells were coated on the surface of it. The DOX-TSMLs-AuNSs-PEG delivery system was synthesized after SH-PEG2000 modification. This multifunction system was combined with a variety of functions, such as radiofrequency-triggered release, chemo-hyperthermia therapy, and dual-mode magnetic resonance/X-ray imaging. Importantly, the DOX-TSMLs-AuNSs-PEG complex was found to escape from endosomes after cellular uptake by radiofrequency-induced endosome disruption before lysosomal degradation. All results in vitro and in vivo indicated that DOX-TSMLs-AuNSs-PEG is a promising effective drug delivery system for diagnosis and treatment of tumors.

pH/Ultrasound Dual‐Responsive Gas Generator for Ultrasound Imaging‐Guided Therapeutic Inertial Cavitation and Sonodynamic Therapy

“…Meanwhile, the H + depletion and chloride influx would also increase the osmotic pressure and cause lysosome swelling . Moreover, ultrasound‐activated ROS generation from HMME and inertial cavitation effect of CO 2 bubbles also were responsible for the endo/lysosomal disruption and redistribution of HMME releasing from endosomal to cytoplasm for further delivery, which was supposed to improve the therapeutic efficacy …”

Gold Nanoparticles as X-Ray, CT, and Multimodal Imaging Contrast Agents: Formulation, Targeting, and Methodology

“…These particles were injected intravenously to assess their accumulation in tumors. Particles did enhance CT contrast, although the majority of particles accumulated in the organs [99]. Li reported a gold nanocluster assembly encapsulated by polyacrylic acid (PAA)/calcium phosphate.…”

“…These were injected intravenously into the tail vein of tumor-bearing mice to test the particles' contrast properties. Relatively high concentrations of the particle were required to create appropriate contrast levels in vivo, and a high accumulation of particles in the liver, lungs, and spleen was found [99]. Tian et al studied attachment of gold Journal of Nanomaterials 9 nanoparticles to a gadolinium-organometallic framework, rather than a gold particle with gadolinium chelates.…”

Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications

“…For the RF groups, the cells were exposed to a 13.56-MHz RF field for 5 min, and then they were incubated with the preparations for 5 h. Cell inhibition was measured by using sulforhodamine B assay after a further 24 h of incubation. 33 The cells were divided into the following groups: DTX, PLGA/AuNR/MnO 2 , PLGA/DTX@MnO 2 , and PLGA/ AuNR/DTX@MnO 2 groups with or without RF treatment.…”

“…41,46 Gold nanoshells and Fe 3 O 4 NPs have been used to prepare a core-shell structured delivery system that had the dual-mode imaging effect. 33 Kim et al 47 used Mn 2+ and Fe 3 O 4 to prepare a delivery system, showing the T 1 /T 2 dual-mode MRI effect. Nowadays, in cancer research, a number of dual-mode imaging drug delivery systems have been constructed for tumor theranostic applications 48,49 as they have more advantages.…”