Radiofrequency-Triggered Release for On-Demand Delivery of Therapeutics From Titania Nanotube Drug-Eluting Implants

Bariana, Manpreet; Aw, Moom Sinn; Moore, Eli; Voelcker, Nicolas H.; Lošić, Dušan

doi:10.2217/nnm.13.93

Cited by 43 publications

(27 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The post‐formed PFH MBs significantly enhanced the contrast of US imaging (Figure c 2 and c 3 ). In addition, radiofrequency (RF) ablation has been widely used for minimally invasive and localized tumor hyperthermia, which is also considered as the irradiation source to trigger the phase transformation of droplets and generate MBs. For instance, solid DL‐menthol (DLM, melting point: 32–36 °C) was encapsulated into PLGA nanocapsules .…”

Section: Nanoparticulate Cas For Responsive Us Imagingmentioning

confidence: 99%

Materials Chemistry of Nanoultrasonic Biomedicine

2016

View full text Add to dashboard Cite

As a special cross-disciplinary research frontier, nanoultrasonic biomedicine refers to the design and synthesis of nanomaterials to solve some critical issues of ultrasound (US)-based biomedicine. The concept of nanoultrasonic biomedicine can also overcome the drawbacks of traditional microbubbles and promote the generation of novel US-based contrast agents or synergistic agents for US theranostics. Here, we discuss the recent developments of material chemistry in advancing the nanoultrasonic biomedicine for diverse US-based bio-applications. We initially introduce the design principles of novel nanoplatforms for serving the nanoultrasonic biomedicine, from the viewpoint of synthetic material chemistry. Based on these principles and diverse US-based bio-application backgrounds, the representative proof-of-concept paradigms on this topic are clarified in detail, including nanodroplet vaporization for intelligent/responsive US imaging, multifunctional nano-contrast agents for US-based multi-modality imaging, activatable synergistic agents for US-based therapy, US-triggered on-demand drug releasing, US-enhanced gene transfection, US-based synergistic therapy on combating the cancer and potential toxicity issue of screening various nanosystems suitable for nanoultrasonic biomedicine. It is highly expected that this novel nanoultrasonic biomedicine and corresponding high performance in US imaging and therapy can significantly promote the generation of new sub-discipline of US-based biomedicine by rationally integrating material chemistry and theranostic nanomedicine with clinical US-based biomedicine.

show abstract

Section: Nanoparticulate Cas For Responsive Us Imagingmentioning

confidence: 99%

Materials Chemistry of Nanoultrasonic Biomedicine

2016

View full text Add to dashboard Cite

show abstract

“…As the most promising photocatalyst, titania materials (TiO 2 ) have been expected to play an important role in a wide range of fields including environmental pollution control, photocatalyst, and high effect solar cell due to their excellent physicochemical properties such as relatively high photocatalytic activity, thermal and chemical stability, nonphoto corrosive, being nontoxic, being capable of photooxidative destruction of most organic pollutants, and low cost [1][2][3][4][5]. Numerous recent research has shown that the photocatalytic activity of titania materials is mainly influenced by the surface area, grain size, crystallinity, crystal structure, band gap, and so forth [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Study on Synthesis and Photocatalytic Activity of Porous Titania Nanotubes

Liu

Zhang

Yang

et al. 2016

Advances in Materials Science and Engineering

View full text Add to dashboard Cite

Using the common natural cellulose substance (filter paper) and triblock copolymer (Pluronic P123) micelles as dual templates, porous titania nanotubes with enhanced photocatalytic activity have been successfully synthesized through sol-gel methods. Firstly, P123 micelles were adsorbed onto the surfaces of cellulose nanofibers of filter paper, followed by hydrolysis and condensation of tetrabutyl titanate around these micelles to form titania layer. After calcination to remove the organic templates, hierarchical titania nanotubes with pores in the walls were obtained. The sample was characterized by X-ray diffraction pattern (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier Transform Infrared Spectroscopy (FT-IR), Ultraviolet-Visible Diffuse Reflectance Spectroscopy (UV-Vis DRS), and X-ray photoelectron spectroscopy (XPS). As compared with commercial P25 catalyst, the porous titania nanotubes prepared by this method displayed significantly enhanced photocatalytic activity for degrading methyl orange under UV irradiation. Within 10 minutes, the porous titania nanotubes are able to degrade over 70% of the original MO, while the value for the commercial Degussa P25 is only about 33%.

show abstract

“…In vitro drug release with the aid of polymeric micelles as drug nano-carriers [93][94] and targeted drug release by means of Smart Drug Delivery Systemgold nanoparticles stimulated by radiofrequency field [95] and magnetic nanoparticles under the influence of a magnetic nanoparticles that are under the influence of a magnetic field [96].…”

Section: Nanoporous Engineered Drug Deliverymentioning

confidence: 99%

Smart Drug Delivery Strategies Based on Porous Nanostructure Materials

Wang¹,

Huang²,

Lai³

2016

Smart Drug Delivery System

View full text Add to dashboard Cite

The control of drug delivery can have a great effect on its efficacy. An optimum concentration range of drugs can play a significant role in the human body, and it can cause harm to humans when it exceeds the range of the drug concentration. Recently, a variety of drug deliveries and their targeted systems have been studied to minimize drug loss and maximize the amount of drug accumulated in the required area, thus increasing drug bioavailability. In addition, we should especially consider the prevention of its harmful side-effects in the human body. Innovative drug delivery systems based on biodegradable, natural or synthetic polymers, micro-or nano-particles, lipoproteins, micelles, TiO 2 nanotube arrays (TNTs), nanoporous anodic aluminum oxide (AAO), and so on were developed, which combined magnetic targeting and stimulus-responsive in drug delivery systems. The composition of delivery carriers and the stimulus-responsive elements proved stimulus-responsive drug release as a smart drug delivery system.

show abstract

Radiofrequency-Triggered Release for On-Demand Delivery of Therapeutics From Titania Nanotube Drug-Eluting Implants

Abstract: The results of this study show that RF is a promising strategy for triggered release from implantable drug delivery systems where on-demand delivery of therapeutics is required.

Cited by 43 publications

References 49 publications

Materials Chemistry of Nanoultrasonic Biomedicine

Materials Chemistry of Nanoultrasonic Biomedicine

Study on Synthesis and Photocatalytic Activity of Porous Titania Nanotubes

Smart Drug Delivery Strategies Based on Porous Nanostructure Materials

Contact Info

Product

Resources

About