Radiofrequency Pulmonary Artery Ablation for Treatment of Residual Pulmonary Hypertension After Pulmonary Endarterectomy

Abstract

медицинский исследовательский центр им. акад. Е. Н. Мешалкина» Минздрава России, Новосибирск 2 ФГБУ «Национальный медицинский исследовательский центр профилактической медицины» Минздрава России, Москва Применение радиочастотной абляции легочной артерии при лечении резидуальной легочной гипертензии после легочной эндартерэктомии Ключевые слова: резидуальная легочная гипертензия, барорецепторы, вторичная васкулопатия, радиочастотная абляция легочной артерии, легочная эндартерэктомия.

Meta-analysis of Pulmonary Artery Denervation for Treatment of Pulmonary Hypertension

“…A total of 188 articles were retrieved and 8 studies were nally included, which are all prospective studies and involve a total of 213 patients [13,[16][17][18][19][20][21][22]. All patients were treated with PADN and followed up for 1-12 months.…”

“…Apart from targeted drug therapy and etiological treatment, some patients with con rmed chronic thromboembolic pulmonary hypertension (CTEPH) can be cured by pulmonary artery endarterectomy (PAE) [39,40]. PADN also could be used in in CTEPH patients with residual pulmonary hypertension after PEA [19]. And the research also proves that PADN has effects on many types of PAH such as connective tissue disease-related PAH, drug-related PAH, and idiopathic PAH [13].…”

“…The results showed that after PADN, the mPAP decreased signi cantly (MD -12.51, 95% CI -17.74 to -7.27, P 0.00001) (mmHg) ( Figure 3A). 8 studies (n = 213) for meta-analysis of PVR [13,[16][17][18][19][20][21][22]. Meta-analysis results showed that there was signi cant heterogeneity between the literatures (P <0.00001, I 2 = 93%), which was analyzed using a random effects model.…”

“…5 studies (n = 124) reported 6MWD [16,17,[19][20][21][22]. There was obvious heterogeneity in these studies (P 0.00001 ; I 2 = 85%) and the random effects model was conducted.…”

Pulmonary artery denervation in patients with pulmonary hypertension: present state and clinical experience

“…акад. Е. Н. Мешалкина, г. Новосибирск и НМИЦ профилактической медицины, г. Москва) стартовало исследование, целью которого было изучить эффективность и безопасность РЧА ЛА с использованием нефлюроскопической системы навигации у пациентов с резидуальной хронической тромбоэмболической ЛГ после операции тромбэндартерэктомии [19,20]. 50 пациентов подверглись вмешательству.…”