Radiofrequency Lesion Adjacent to the Dorsal Root Ganglion for Cervicobrachial Pain: A Prospective Double Blind Randomized Study

Kleef, Maarten van; Liem, Leon K.; Lousberg, Richel; Barendse, Gerard A.M.; Kessels, Fons; Sluijter, Menno E.

doi:10.1227/00006123-199606000-00013

Cited by 18 publications

(26 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…16,17 From these studies, one can conclude that RF is superior to sham intervention and that RF at 67°C results in similar pain relief as RF at 40°C. 17 However, a well-designed RCT comparing RF adjacent with the lumbar DRG with a sham intervention did not demonstrate significant pain reduction for the management of lumbosacral radicular pain.…”

Section: Treatment Of Radicular Painmentioning

confidence: 89%

Pulsed Radiofrequency

Boxem

Huntoon

Zundert

et al. 2014

Regional Anesthesia and Pain Medicine

Self Cite

View full text Add to dashboard Cite

Radicular pain is an important health care problem, with only limited evidence-based treatments available. Treatment selection should ideally target documented pathophysiological pathways. In herniated discs, a sequence in the inflammatory cascade can be observed that initiates and maintains increased nociceptive signal input. Inflammatory mediators including tumor necrosis factor α are released from the nucleus pulposus and the degenerating peripheral nerve, which, in turn, induces production of neurotrophins like nerve growth factor and brain-derived neurotrophic factor. Neurotrophins interfere not only with the generation of ectopic firing of nociceptive neurons in the dorsal root ganglion but also with the excitability and sensitization of neuronal transmission in the dorsal spinal horn. Radicular pain is further characterized by the electrophysiological spreading of the afferent nociceptive input over different spinal nerve roots. Both the complex pathophysiological pathways involved and the spreading of the nociceptive signal make radicular pain difficult to treat. Pulsed radiofrequency (PRF) is considered an option in treatment of radicular pain. To understand and increase the efficiency of PRF interventional treatments in radicular pain, both in vitro and in vivo studies aiming at elucidating part of the mechanism of action of PRF are described. Potential factors that may improve the efficacy of PRF treatment in radicular pain are discussed.

show abstract

Section: Treatment Of Radicular Painmentioning

confidence: 89%

Pulsed Radiofrequency

Boxem

Huntoon

Zundert

et al. 2014

Regional Anesthesia and Pain Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…85 For the RF procedure, the same viewing technique is used. This axis points 25 to 35 degrees anteriorly and 10 degrees caudally.…”

Section: Methodsmentioning

confidence: 99%

Radiofrequency Treatment

Eerd¹,

Kleef²,

Zundert³

2014

Practical Management of Pain

Self Cite

View full text Add to dashboard Cite

“…[60][61][62] In one study, thermal RF adjacent to the DRG relieved pain at 2 months posttreatment, although some inflammation and loss of muscle strength were reported. 63 Another study of RF at cervical DRGs reported no significant differences in outcomes with probe temperatures of 40°C and 67°C. 56,60,64 In the thoracic region, partial DRG denervation via RF resulted in excellent or good results for more than 80% of patients at a median follow-up of 24 months.…”

Section: Radiofrequency Treatmentsmentioning

confidence: 98%

The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain

Liem

Dongen

Huygen

et al. 2016

Regional Anesthesia and Pain Medicine

View full text Add to dashboard Cite

Chronic neuropathic pain is a widespread problem with negative personal and societal consequences. Despite considerable clinical neuroscience research, the goal of developing effective, reliable, and durable treatments has remained elusive. The critical role played by the dorsal root ganglion (DRG) in the induction and maintenance of chronic pain has been largely overlooked in these efforts, however. It may be that, by targeting this site, robust new options for pain management will be revealed. This review summarizes recent advances in the knowledge base for DRG-targeted treatments for neuropathic pain:• Pharmacological options including the chemical targeting of voltage-dependent calcium channels, transient receptor potential channels, neurotrophin production, potentiation of opioid transduction pathways, and excitatory glutamate receptors.• Ablation or modulation of the DRG via continuous thermal radiofrequency and pulsed radiofrequency treatments.• Implanted electrical neurostimulator technologies.• Interventions involving the modification of DRG cellular function at the genetic level by using viral vectors and gene silencing methods.

show abstract

Radiofrequency Lesion Adjacent to the Dorsal Root Ganglion for Cervicobrachial Pain: A Prospective Double Blind Randomized Study

Cited by 18 publications

References 9 publications

Pulsed Radiofrequency

Pulsed Radiofrequency

Radiofrequency Treatment

The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain

Contact Info

Product

Resources

About