Radiofrequency electric field hyperthermia with gold nanostructures: role of particle shape and surface chemistry

Abstract

Hyperthermia treatment of cancerous cells has been recently developed drastically with the help of nanostructures. Heating of gold nanoparticles in non-invasive radiofrequency electric field (RF-EF) is a promising and unique technique for cancer hyperthermia. However, because of differences between particles (i.e. their surface chemistry and dispersion medium) and between RF-EF sources, the research community has not reached a consensus yet. Here, we report the results of investigations on heating of gold nanoparticles and gold nanorods under RF-EF and feasibility of in-vitro cancer hyperthermia. The heating experiments were performed to investigate the role of particle shape and surface chemistry (CTAB, citrate and PEG molecules). In-vitro hyperthermia was performed on human pancreatic cancer cell (MIA Paca-2) with PEG-coated GNPs and GNRs at concentrations that were found non-toxic based on the results of cytotoxicity assay. Application of RF-EF on cells treated with PEG-GNPs and PEG-GNRs proved highly effective in killing cells.

Electromagnetic radiation driving of volume changes in nanocomposites made of a thermosensitive hydrogel polymerized around conducting polymer nanoparticles

“…RF radiation has been frequently used to increase the temperature of magnetic or metallic materials. [63][64][65] In the case of conductive materials, the oscillating electromagnetic eld creates eddy currents inside the material which heat the material by Joule effect (since the material has a nite conductivity). Additionally, the oscillating magnetic eld could interact with polar groups and the fast reorientation cause dielectric loss.…”

Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications

“…In this case, the nanosensitizers are electrically-conductive NPs that can produce Joule heating through the RF-induced electrical currents over the NP volume [ 169 ]. The NPs that provide the strongest absorption of RF radiation are gold [ 170 , 171 ] and carbon nanomaterials [ 172 ]. Tamarov and co-workers studied crystalline silicon based nanomaterials (porous silicon-based (PSi) NPs and laser-ablated Si NPs) as sensitizers for RF-induced therapy [ 163 ].…”

Synthesis and characterisation of liposomal doxorubicin with loaded gold nanoparticles

“…1a). Based on our previous study, the diameter of GNPs was 7.3 ± 7.1 nm [18]. As a result of CTAB presence at the surface of GNPs, they are positively charged [25] and they could interact with negatively charged liposomes with electrostatic interaction.…”