Radiofrequency Ablation Versus Surgical Resection for Hepatocellular Carcinoma in Childs A Cirrhotics—a Retrospective Study of 1,061 Cases

Huang, Jiwei; Hernandez‐Alejandro, Roberto; Croome, Kristopher P.; Yan, Lvnan; Wu, Hong; Chen, Zhe-Yu; Prasoon, Pankaj; Zeng, Yong

doi:10.1007/s11605-010-1372-y

Cited by 73 publications

(79 citation statements)

References 32 publications

(36 reference statements)

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“…While liver resection and RFA are still the standard treatments for many HCC patients, the long-term effects of surgical resection vs RFA remain controversial [31][32][33] . Thus, when many patients of HCV-related HCC become able to be treated with IFN-free therapies, this issue may be re-evaluated.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Honda

Seike

Oribe

et al. 2016

WJH

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AIM:To identify factors that influence long-term liver function following radiofrequency ablation (RFA) in patients with viral hepatitis-related hepatocellular carcinoma. METHODS:A total of 123 patients with hepatitis B virus-or hepatitis C virus-related hepatocellular carcinoma (HCC) (n = 12 and n = 111, respectively) were enrolled. Cumulative rates of worsening Child-Pugh (CP) scores (defined as a 2-point increase) were examined. RESULTS:CP score worsening was confirmed in 22 patients over a mean follow-up period of 43.8 ± 26.3 mo. Multivariate analysis identified CP class, platelet count, and aspartate aminotransferase levels as significant predictors of a worsening CP score (P = 0.000, P = 0.011 and P = 0.024, respectively). In contrast, repeated RFA was not identified as a risk factor for liver function deterioration. CONCLUSION:Long-term liver function following RFA was dependent on liver functional reserve, the degree Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy Retrospective Cohort Study ORIGINAL ARTICLEof fibrosis present, and the activity of the hepatitis condition for this cohort. Therefore, in order to maintain liver function for an extended period following RFA, suppression of viral hepatitis activity is important even after the treatment of HCC. Core tip: This study was conducted to identify risk factors for liver function deterioration following radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC) and viral hepatitis. A total of 123 patients with hepatitis B virus-or hepatitis C virusrelated HCC were enrolled. Cumulative rates of worsening Child-Pugh (CP) scores (defined as a 2-point increase) following RFA were examined. CP class, platelet count, and aspartate aminotransferase levels were identified as significant predictors of a worsening CP score. Suppression of viral hepatitis activity with anti-viral therapy is important even after the treatment of HCC in order to maintain liver function following RFA.

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Section: Discussionmentioning

confidence: 99%

Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Honda

Seike

Oribe

et al. 2016

WJH

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“…When compared with liver resection, RFA generally is associated with lower morbidity in patients with small HCC (Feng et al 2014). However, efficacy of RFA versus surgical resection in the treatment of early HCC remains an ongoing issue (Cho et al 2011;Huang et al 2011;Feng et al 2014). Several randomized controlled studies have shown comparable overall survival of RFA versus surgical resection in patients with small HCC (tumor size less than 4 cm) Feng et al 2012).…”

Section: Locoregional Therapymentioning

confidence: 99%

“…However, the subgroup analysis by Chen et al showed higher diseasefree survival rate in the resection group when tumor size ranged from 3.1 to 5.0 cm (65% at 3 yr vs. 45% in the RFA group) . Recently, a meta-analysis of 22 studies concluded that there were superior survival outcomes from surgical resection of HCCs measuring .3 cm compared with RFA (Cho et al 2011;Huang et al 2011;Feng et al 2014). Given the nonsuperiority of RFA over surgical resection in small HCC, its inferiority in larger tumors, and the reported 12.5% risk of needletrack tumor seeding (Llovet et al 2001), the guidelines only recommend ablation in small tumors that are not amendable to surgical resection or transplantation (Fong and Tanabe 2014).…”

Section: Locoregional Therapymentioning

confidence: 99%

Treatment of Liver Cancer

Liu

Chen

2015

Cold Spring Harb Perspect Med

258

188

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Primary liver cancer, mostly hepatocellular carcinoma, remains a difficult-to-treat cancer. Incidence of liver cancer varies geographically and parallels with the geographic prevalence of viral hepatitis. A number of staging systems have been developed, reflecting the heterogeneity of primary liver cancer, regional preferences, and regional variations in resectability or transplant eligibility. Multimodality treatments are available for this heterogeneous malignancy, and there are variations in the management recommendations for liver cancers across specialties and geographic regions. Novel treatment strategies have merged with the advance of new treatment modalities. This work focuses on reviewing the incidence, staging, and treatment of liver cancer.

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“…These patients exceed the Milan criteria for liver transplantation, and their access to transplantation is a balance of maximising their chances of cure and organ availability [15,16]. For thermal ablative techniques, such as radiofrequency ablation (RFA), HCC >5 cm in diameter are usually too bulky, resulting in incomplete ablation and a high risk of local recurrence [17,18]. Even if some authors report smaller series of successful thermal ablation of HCC up to 7 cm in diameter, a diameter of 3-4 cm is usually accepted as the upper size limit for thermal ablation in the liver [19,20].…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma: computed-tomography-guided high-dose-rate brachytherapy (CT-HDRBT) ablation of large (5–7 cm) and very large (>7 cm) tumours

et al. 2011

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Radiofrequency Ablation Versus Surgical Resection for Hepatocellular Carcinoma in Childs A Cirrhotics—a Retrospective Study of 1,061 Cases

Cited by 73 publications

References 32 publications

Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Risk factors for deterioration of long-term liver function after radiofrequency ablation therapy

Treatment of Liver Cancer

Hepatocellular carcinoma: computed-tomography-guided high-dose-rate brachytherapy (CT-HDRBT) ablation of large (5–7 cm) and very large (>7 cm) tumours

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