Radiofrequency Ablation Treatment of Refractory Carcinoid Hepatic Metastases

“…Furthermore, different treatment methods ranging from radiofrequency ablation (RFA) or transarterial chemoembolization (TACE) to liver transplantation for hepatic metastases can be attempted in patients with gastric NETs, often resulting in good symptomatic relief and up to 80 % 5-year survival in select cases (8)(9)(10), but not in patients with gastric ADCs, Thus, an attempt to discriminate the origin of hepatic metastases would be of great clinical significance.…”

Section: Introductionmentioning

confidence: 99%

CT differentiation of poorly-differentiated gastric neuroendocrine tumours from well-differentiated neuroendocrine tumours and gastric adenocarcinomas

Kim

et al. 2015

Eur Radiol

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“…This often consists of removal of primary tumor and debulking metastases. Various other cytoreductive techniques are also often useful and include radiofrequency ablation (Wessels & Schell 2001), cryoablation (Seifert et al 1998), biological modulation (octreoscan, lanreotide, alpha interferon) (Frank et al 1999(Frank et al , Ö berg 2001, HACE injection (Mitty et al 1985, Rusniewski et al 1993, Diaco et al 1995, Yao et al 2001, Soulen 2002) and internal and external radiotherapy and chemotherapy (Pelley & Bukowski 1999, Jensen 2000, Ö berg 2001.…”

Section: Discussionmentioning

confidence: 99%

Carcinoid case presentation and discussion: the American perspective.

Warner

2003

Endocrine-Related Cancer

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The rationale underlying an aggressive approach in the management of some carcinoid patients is explained and illustrated by the presented case of a middle-aged man with advanced classic typical midgut carcinoid. The patient exhibited somatostatin receptor scintigraphy-positive massive liver metastases, carcinoid syndrome, severe tricuspid and pulmonic cardiac valve disease with congestive heart failure, ascites and malnutrition. He had been treated for several years with supportive medications and biotherapy including octreotide and alpha interferon but his tumor eventually progressed and his overall condition was markedly deteriorated when he first sought more aggressive treatment. This consisted of prompt replacement of both tricuspid and pulmonic valves, followed by hepatic artery chemoembolus (HACE) injection and then surgical tumor debulking including excision of the primary tumor in the small intestine. In addition, radiofrequency ablation was utilized to reduce the volume of metastases in the liver. Prophylactic cholecystectomy was also performed and a biopsy of tumor was submitted for cell culture drug resistance testing. This was followed by systemic chemotherapy utilizing the drug (docetaxel) which the in vitro studies suggested as most likely to be effective. His excellent response to this succession of treatments exemplifies the successful application of aggressive sequential multi-modality therapy.

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Radiofrequency Ablation Treatment of Refractory Carcinoid Hepatic Metastases

Cited by 67 publications

References 17 publications

Guidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms) Part I—General Overview

Guidelines for the management of gastroenteropancreatic neuroendocrine tumours (including bronchopulmonary and thymic neoplasms) Part I—General Overview

CT differentiation of poorly-differentiated gastric neuroendocrine tumours from well-differentiated neuroendocrine tumours and gastric adenocarcinomas

Carcinoid case presentation and discussion: the American perspective.

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