Radioembolization After Portal Vein Embolization in a Patient with Multifocal Hepatocellular Carcinoma

Burgmans, Mark C.; Irani, Farah Gillan; Chan, Wan Ying; Teo, T.; Kao, Yung Hsiang; Goh, Anthony; Chow, Pierce K. H.; Lo, Richard Hoau Gong

doi:10.1007/s00270-012-0376-2

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Because PVTT is a heterogeneous entity with significant prognostic variation, there are likely to be some patients who will benefit from local therapy rather than sorafenib. Theoretically, locoregional therapies such as TACE, radioembolization, and/or RT could suppress PVTT progression and delay intravascular tumor growth and the deterioration of liver function by maintaining adequate portal flow [ 22 , 23 ]. In fact, RT has been reported to yield fair outcomes with an objective response rate of approximately 40% to 50% and a median survival duration of 9 to 10 months [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Multicenter Validation Study of a Prognostic Index for Portal Vein Tumor Thrombosis in Hepatocellular Carcinoma

Yoon

Park

et al. 2014

Cancer Res Treat

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PurposeWe previously reported on a staging system and prognostic index (PITH) for portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) patients treated with radiotherapy (RT) at a single institution. The aim of this study is to validate the PITH staging system using data from patients at other institutions and to compare it with other published staging systems.Materials and MethodsA total of 994 HCC patients with PVTT who were treated with RT between 1998 and 2011 by the Korean Radiation Oncology Group were analyzed retrospectively. All patients were staged using the Cancer of the Liver Italian Program (CLIP), Japanese Integrated Staging (JIS), Okuda, and PITH staging systems, and survival data were analyzed. The likelihood ratio, Akaike information criteria (AIC), time-dependent receiver operating characteristics, and prediction error curve analysis were used to determine discriminatory ability for comparison of staging systems.ResultsThe median survival was 9.2 months. Compared with the other staging systems, the PITH score gave the highest values for likelihood ratio and lowest AIC values, demonstrating that PITH may be a better prognostic model. Although the values were not significant and differences were not exceptional, the PITH score showed slightly better performance with respect to time-dependent area under curve and integrated Brier score of prediction error curve.ConclusionThe PITH staging system was validated in this multicenter retrospective study and showed better stratification ability in HCC patients with PVTT than other systems.

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Section: Discussionmentioning

confidence: 99%

Multicenter Validation Study of a Prognostic Index for Portal Vein Tumor Thrombosis in Hepatocellular Carcinoma

Yoon

Park

et al. 2014

Cancer Res Treat

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“…Patients with hepatic tumors who would otherwise not be surgical candidates because of an insufficient volume of normal liver to allow resection may benefit from embolization of the portal vein supplying the tumor-containing lobe. This produces significant hypertrophy of the contralateral hepatic lobe and has proved to be both safe and effective, especially in those individuals with a small left lobe who require a right, or extended right, hepatic resection [44][45][46][47].…”

Section: Portal Vein Embolizationmentioning

confidence: 99%

Non-Operative Management of Hepatic Trauma and the Interventional Radiology: An Update Review

Pereira¹

2012

Indian J Surg

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The growing trend to manage hepatic injuries nonoperatively has been increasing demand for advanced endovascular interventions. This brings up the necessity for general and trauma surgeons to update their knowledge in such matter. Effective treatment mandates a multispecialty team effort that is usually led by the trauma surgeon and includes vascular surgery, orthopedics, and, increasingly, interventional radiology. The focus on hemorrhage control and the angiographer's unique access to vascular structures gives interventional radiology (IR) an important and increasingly recognized role in the treatment of patients with hemodynamic instability. Our aim is to review the basic concepts of IR primarily in hepatic trauma and secondarily in some other special situations. A liver vascular anatomy review is also needed for better understanding the roles of IR. As a final point we propose a guideline for the operative/nonoperative management of traumatic hepatic injuries. The benefit of multidisciplinary approach (TAE) appears to be a powerful weapon in the medical arsenal against the high mortality of injured trauma liver patients.

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Portal vein ligation versus portal vein embolization for induction of hypertrophy of the future liver remnant: A systematic review and meta-analysis

et al. 2017

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Radioembolization After Portal Vein Embolization in a Patient with Multifocal Hepatocellular Carcinoma

Cited by 4 publications

References 11 publications

Multicenter Validation Study of a Prognostic Index for Portal Vein Tumor Thrombosis in Hepatocellular Carcinoma

Multicenter Validation Study of a Prognostic Index for Portal Vein Tumor Thrombosis in Hepatocellular Carcinoma

Non-Operative Management of Hepatic Trauma and the Interventional Radiology: An Update Review

Portal vein ligation versus portal vein embolization for induction of hypertrophy of the future liver remnant: A systematic review and meta-analysis

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