“…However, pure unlabeled sulfasalazine (SSD) was detected at R t = 14.2 min (Figure 3b). Additionally, the non‐radioactive sulfasalazine ([ 127 I]‐SSD) was detected at the same R t as of [ 131 I]‐SSD at R t = 14.8 min (Figure 3c) (Sanad & Talaat, 2017).…”
This study demonstrated the tracking of ulcerative colitis, which is considered a stressful immune disease. Although there are many ways to test for this disease including dependence on gases, dyes, and painful anal endoscopy, these treatment modalities have many disadvantages. Hence, it is the utmost need of time to discover new methods to detect this chronic immune disease and to avoid the defects of traditional methodologies. Sulfasalazine (SSD) was labeled with iodine-131 (half-life: 8 days, Energy: 971 keV) under optimum reaction conditions including the amount F I G U R E 1 Metabolic pathway of sulfasalazine (SSD) and [ 131 I]-iodosulfasalazine ([ 131 I]-SSD) [Colour figure can be viewed at wileyonlinelibrary.com] F I G U R E 3 (a) HPLC radiochromatogram of [ 131 I]-SSD and free [ 131 I]-iodide. (b) HPLC-UV analysis of pure SSD. (c) HPLC-UV analysis of non-radioactive
“…However, pure unlabeled sulfasalazine (SSD) was detected at R t = 14.2 min (Figure 3b). Additionally, the non‐radioactive sulfasalazine ([ 127 I]‐SSD) was detected at the same R t as of [ 131 I]‐SSD at R t = 14.8 min (Figure 3c) (Sanad & Talaat, 2017).…”
This study demonstrated the tracking of ulcerative colitis, which is considered a stressful immune disease. Although there are many ways to test for this disease including dependence on gases, dyes, and painful anal endoscopy, these treatment modalities have many disadvantages. Hence, it is the utmost need of time to discover new methods to detect this chronic immune disease and to avoid the defects of traditional methodologies. Sulfasalazine (SSD) was labeled with iodine-131 (half-life: 8 days, Energy: 971 keV) under optimum reaction conditions including the amount F I G U R E 1 Metabolic pathway of sulfasalazine (SSD) and [ 131 I]-iodosulfasalazine ([ 131 I]-SSD) [Colour figure can be viewed at wileyonlinelibrary.com] F I G U R E 3 (a) HPLC radiochromatogram of [ 131 I]-SSD and free [ 131 I]-iodide. (b) HPLC-UV analysis of pure SSD. (c) HPLC-UV analysis of non-radioactive
“…The animals were kept upping at consistent nourishing conditions all through the trial time and kept at room temperature (22 ± 2 °C) with a 12 h on/off light schedule. The mice were bred in a cage with a free diet and water [51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70].…”
The drug, phenylpiracetam, (PHPI, Iodophenylpiracetam ([131 I]-PHPI)) can prevent retrograde amnesia, and has anticonvulsant properties in models of animal was labeled using [I-131]with Chloramine-T(Ch-T) as an oxidizing agent to give a radiochemical yield of 98%. Many operators such as the amount of oxidizi ng agent, amount of substrate, pH, and reaction time, was systematically studied giving optimum conversion (98%) was obtained. Biodistribution studies indicate the[131I]PHPI tracer focuses on the target organ (brain) with a high percentage that is appropriate to use as a novel tracer for brain imaging. A labeled compound of [131I]-PHPImay be considered a highly selective radiotracer for brain tumor imaging compared withcommercially available radiotracers [99mTc] ECD and [99mTc] HMPAO.
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