Radiocontrast-associated renal dysfunction: a comparison of lower-osmolality and conventional high-osmolality contrast media.

Em, Lautin; Nj, Freeman; Ah, Schoenfeld; Cw, Bakal; Haramati, Nogah; Ac, Friedman; Jl, Lautin; S, Braha; Eg, Kadish

doi:10.2214/ajr.157.1.2048540

Cited by 127 publications

(52 citation statements)

References 29 publications

(1 reference statement)

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“…10 The mean age of the study patients was also within the range (40-60 years) found in one study conducted in Bangladesh. 18 Hayder and Shaheen observed the mean age was a little lesser than the present study.…”

Section: Discussionsupporting

confidence: 58%

“…9 There is a decrease in the incidence of CIN when low osmolar contrast media (LOCM) are used instead of high osmolar contrast media (HOCM). 10 The incidence of nephrotoxicity is less in iso-osmolar non-ionic contrast medium (e.g Iodixanol) than in lowosmolar non-ionic contrast medium (e.g Iopamidol). 11 But one study by Hossain in Bangladesh has shown that no significant difference between iso-osmolar and low-omolar contrast media in patients with chronic kidney disease(CKD).…”

mentioning

confidence: 99%

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Impact of Blood Glucose Levels on Contrast Induced Nephropathy after Percutaneous Coronary Intervention in Patients not known to be Diabetic with Acute Coronary Syndrome.

et al. 2013

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Background: Contrast-Induced Nephropathy (CIN) is an iatrogenic disorder, resulting from exposure to contrast media. The association between pre-procedural blood glucose levels and CI-AKI risk (regardless of pre-existing diabetes) is unknown. The present study was conducted to evaluate the incidence of CI-AKI in patients with admission hyperglycemia in non-diabetic ACS patients. Methods: This is Prospective, observational study done in the department of Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka. Considering inclusion and exclusion criteria, 50 patients were non diabetic with ACS with normal blood glucose (d7.8 mmol/l or d140 mg/dl) in (Group I) and 50 patients were non diabetic with ACS with high blood glucose (>7.8 mmol/l or >140 mg/dl) undergoing percutaneous coronary intervention in (Group II). On admission random blood glucose was measured. Non- ionic low osmolar contrast agents (lopamidol) was used in all patients. Serum creatinine, serum electrolytes was measured and creatinine clearance rate was determined within 24 hours before PCI and day 1 and 2 after PCI. Results: The incidence of CIN was 24% in high blood glucose group and 4% in normal blood glucose group (p=0.004). It was also observed that gradual incremental increase in risk of CIN associated with higher admission blood glucose level. There was positive correlation between s. creatinine and admission blood glucose but it showed negative correlation between CCr and admission blood glucose after PCI in ACS patients not known to be diabetic. Conclusion: The present study reveals that index admission high blood glucose in acute coronary syndrome patients not known to be diabetic is associated with increased incidence of contrast induced nephropathy after percutaneous coronary intervention. Cardiovascular Journal Volume 6, No. 1, 2013, Page 23-30 DOI: http://dx.doi.org/10.3329/cardio.v6i1.16111

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Section: Discussionsupporting

confidence: 58%

mentioning

confidence: 99%

Impact of Blood Glucose Levels on Contrast Induced Nephropathy after Percutaneous Coronary Intervention in Patients not known to be Diabetic with Acute Coronary Syndrome.

et al. 2013

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“…Preexistent low glomerular filtration rate (GFR) and diabetes mellitus 5,[8][9][10] share the strongest evidence as major risk factors. However, age 11 , gender, contrast medium infused volume 9,11,12 and osmolarity 8,[12][13][14][15][16][17][18] , use of angiotensin-converting enzyme (ACE) inhibitors 19 , peripheral artery disease and acute myocardial infarction have also been associated with the development of CIN 4,20,21 .…”

mentioning

confidence: 99%

Há uma associação entre anti-inflamatórios não-esteroides e nefropatia induzida por contraste?

Diogo

Saitovitch²,

Biehl³

et al. 2010

Arq. Bras. Cardiol.

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“…Lautin et al (35) have reported that LOCM induces nephropathy less frequently than HOCM. However, controversial data have been reported by other investigators (36,37).…”

Section: Osmolalitymentioning

confidence: 99%

Clinical and Experimental Evidence for Prevention of Acute Renal Failure Induced by Radiographic Contrast Media

et al. 2005

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Abstract. Acute renal failure still occurs as a complication after radiographic examination using iodinated radiocontrast medium. The incidence rate of radiocontrast medium-induced nephropathy (radiocontrast nephropathy) is low (2 -3%) in general. However, the rate is remarkably elevated in patients with pre-existing renal insufficiency. Radiocontrast nephropathy is associated with increased morbidity and mortality, particularly in patients with percutaneous coronary interventions. Although the reduction in renal blood flow and direct toxic action on renal tubular cells are considered to be involved, little is known about the etiology of radiocontrast nephropathy. A number of agents that improve renal circulation have been clinically tested for prevention of radiocontrast nephropathy, but none of them has succeeded. Protection of renal tubular cells against oxidative stress is another approach to avoid radiocontrast nephropathy. Prophylactic effects of antioxidants such as N-acetylcysteine and ascorbic acid have been reported by several investigators, although the effectiveness of these compounds is still a matter of debate. At present, hydration is regarded as the only effective, though incomplete, prophylactic regimen for radiocontrast nephropathy. Recently, we have shown that caspasedependent apoptosis is an important factor in the pathogenesis of radiocontrast nephropathy and clarified cellular mechanisms underlying the radiocontrast media-induced apoptosis. This review summarizes clinical and experimental evidence for the etiology and prevention of radiocontrast nephropathy.

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Radiocontrast-associated renal dysfunction: a comparison of lower-osmolality and conventional high-osmolality contrast media.

Cited by 127 publications

References 29 publications

Impact of Blood Glucose Levels on Contrast Induced Nephropathy after Percutaneous Coronary Intervention in Patients not known to be Diabetic with Acute Coronary Syndrome.

Impact of Blood Glucose Levels on Contrast Induced Nephropathy after Percutaneous Coronary Intervention in Patients not known to be Diabetic with Acute Coronary Syndrome.

Há uma associação entre anti-inflamatórios não-esteroides e nefropatia induzida por contraste?

Clinical and Experimental Evidence for Prevention of Acute Renal Failure Induced by Radiographic Contrast Media

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