Radiochemistry Automation for PET

Crouzel, C.; Clark, John C.; Brihaye, C.; Långström, Bengt; Lemaire, Christian; Meyer, Geerd J.; Nebeling, B.; Stone‐Elander, Sharon

doi:10.1007/978-94-015-8204-9_2

Cited by 43 publications

(26 citation statements)

References 39 publications

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“…Wholebody glucose uptake, a measurement of insulin sensitivity, was calculated from the glucose infusion rate after correcting for changes in the glucose pool size [16]. [18]. Sterility and pyrogenity tests for water, and chromatographic analysis for gases were performed to verify the purity of the products.…”

Section: Methodsmentioning

confidence: 99%

High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes

et al. 2004

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Aims/hypothesis. Elevated high-sensitivity C-reactive protein (hsCRP) concentrations indicate increased risk of future coronary events. The association between hsCRP and coronary vasoreactivity has not yet been examined in type 1 diabetic subjects. Methods. We studied 18 young men who were non-smokers and who had uncomplicated type 1 diabetes. The diabetic subjects were divided into two groups, according to their median hsCRP concentration, as follows: (i) subjects with slightly elevated hsCRP (median 0.76 mg/l, range 0.47-4.73 mg/l, n=8); and (ii) subjects with low hsCRP (median 0.32 mg/l, range 0.11-0.35 mg/l, n=10). In addition we investigated 22 non-diabetic age-matched subjects (hsCRP: median 0.42 mg/l, range 0.11-1.31 mg/l). Resting myocardial blood flow and hyperaemic adenosine-stimulated flow during euglycaemic-hyperinsulinaemic clamp were determined using positron emission tomography and oxygen-15 -labelled water.Results. Diabetic subjects with slightly elevated hsCRP had significantly higher hsCRP concentrations than nondiabetic subjects (p=0.008). Resting myocardial blood flow was similar (NS) in diabetic subjects with slightly elevated hsCRP (0.79±0.19 ml·g −1 ·min −1 ) or low hsCRP (0.81±0.15 ml·g −1 ·min −1 ) and non-diabetic subjects (0.80±0.19 ml·g −1 ·min −1 ). Adenosine infusion induced a significant increase in blood flow in all study subjects (p<0.001) but was blunted in diabetic subjects with slightly elevated hsCRP (3.42±0.61 ml·g −1 ·min −1 ) when compared with diabetic subjects with low hsCRP (5.08±1.65 ml·g −1 ·min −1 , p=0.02) or non-diabetic subjects (4.51±1.36 ml·g −1 ·min −1 , p=0.04). Adenosine-stimulated flow was inversely correlated with hsCRP concentrations in all diabetic subjects (r=−0.70, p=0.001). Conclusions/interpretation. In young subjects with uncomplicated type 1 diabetes, even slightly elevated hsCRP concentrations are associated with reduced coronary vasoreactivity.Keywords Adenosine · hsCRP · Myocardial blood flow · Positron emission tomography · Type 1 diabetes High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes

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Section: Methodsmentioning

confidence: 99%

High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes

et al. 2004

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“…We produced 15 O using a low-energy deuteron accelerator Cyclone 3 (Ion Beam Application, Louvain-la-Neuve, Belgium). To produce [ 15 O]H 2 O, we used dialysis techniques in a continuously working water module [9,10]. In order to verify the purity of the products, we carried out sterility and pyrogenity tests for water, and chromatographic analysis for gases.…”

Section: Production Of [15o]h2omentioning

confidence: 99%

Diabetic background retinopathy is associated with impaired coronary vasoreactivity in people with Type 1 diabetes

et al. 2004

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Aims/hypothesis. We examined whether diabetic background retinopathy is associated with reduced coronary vasoreactivity in people with Type 1 diabetes. Methods. A total of 21 men with Type 1 diabetes were investigated, including 9 men with background retinopathy and 12 men without retinopathy. In addition, 12 non-diabetic, age-matched subjects were studied. All subjects were non-smokers, otherwise healthy and had no other diabetic complications. Resting myocardial blood flow and hyperaemic dipyridamole-stimulated flow (dipyridamole, 0.56 mg/kg during a 4-min period), a measure of coronary vasoreactivity, were measured during euglycaemic hyperinsulinaemic clamp (1 mU·kg −1 ·min −1 ) using positron emission tomography and oxygen-15-labelled water. Results. Resting myocardial blood flow (0.82±0.13 vs 0.96±0.23 vs 0.88±0.25 ml·g −1 ·min −1 , with vs without retinopathy vs non-diabetic subjects) and coronary vascular resistance (111.2±23.4 vs 95.5±15.8 vs 101.9±31.5 mmHg·min·g·ml −1 respectively) were not significantly different between the groups. Dipyridamole infusion induced an increase in blood flow and a decrease in coronary vascular resistance in all study subjects (p<0.001). However, dipyridamole-stimulated flow and coronary vascular resistance were blunted in diabetic patients with retinopathy (2.9±0.9 ml·g −1 · min −1 and 34.1±11.3 mmHg·min·g·ml −1 ) when compared to diabetic patients without retinopathy (4.0±1.3 ml·g −1 ·min −1 , p=0.04 and 24.6±7.5 mmHg·min·g·ml −1 , p=0.03) or non-diabetic subjects (4.5±1.4 ml·g −1 ·min −1 , p=0.008 and 22.2±8.7 mmHg·min·g·ml −1 , p=0.01). Myocardial flow reserve was impaired in diabetic patients with retinopathy (3.6±1.0) when compared to non-diabetic subjects (5.3±1.9, p=0.02) but not significantly reduced when compared to diabetic patients without retinopathy (4.2±1.4, p=0.2). Conclusions/interpretation. Diabetic background retinopathy appears to be associated with impaired coronary vasoreactivity in young people with Type 1 diabetes.Keywords Myocardial blood flow · Type 1 diabetes · Retinopathy · Dipyridamole · Positron emission tomography

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“…Thereafter, physiological hyperinsulinemia (1 mU/kg/min) 26 was started and continued for 60 min before the second intravenous infusion of adenosine 27 15 O-labelled water was produced using dialysis techniques in a continuously working water module. 28 Sterility and pyrogenity tests for water and chromatographic analysis for gases were performed to verify the purity of the products.…”

Section: Methodsmentioning

confidence: 99%

Short-term changes in inflammatory response protein (hsCRP) do not parallel with changes in coronary vasoreactivity in obese men

et al. 2005

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Aim: Obese subjects are characterized by increased high-sensitivity C-reactive protein (hsCRP) and coronary vascular resistance. Clucocorticoids suppress inflammation, a possible cardioprotective effect. We tested the short-term anti-inflammatory effect of dexamethasone (dx) on these parameters in obese subjects. Methods: Coronary vascular resistance was quantitated basally and during adenosine infusion with or without simultaneous euglycemic hyperinsulinemic clamp (insulin infusion rate of 1 mU/kg/min) in 11 obese and 19 age-matched nonobese males using positron emission tomography and 15 O-water. Each subject was studied both with and without previous dx treatment for 2 days (2 mg/day). Results: Before dx treatment, hsCRP concentration was significantly higher in obese than in nonobese subjects (1.5571.73 vs 0.3270.32 mg/l, P ¼ 0.005). In addition, coronary vascular resistances were higher (Po0.05) in obese than in nonobese subjects at baseline (139736 vs 117722) and during adenosine infusion without (3277 vs 2677) or with simultaneous clamp (2678 vs 2175 mmHg min g/ ml). Dx treatment decreased significantly hsCRP concentration in obese but not in nonobese subjects, leading to similar hsCRP concentrations between the groups (0.4570.43 vs 0.2670.42 mg/l, respectively, P ¼ 0.3). Dx had no effect on coronary vascular resistances (NS). Conclusions: Obese subjects are characterized by high hsCRP, which can be normalized by dx. However, despite this, coronary vascular resistances did not decrease in obese subjects. Short-term changes in inflammatory response protein appear not to parallel with changes in coronary vasoreactivity in obese men.

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Radiochemistry Automation for PET

Cited by 43 publications

References 39 publications

High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes

High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes

Diabetic background retinopathy is associated with impaired coronary vasoreactivity in people with Type 1 diabetes

Short-term changes in inflammatory response protein (hsCRP) do not parallel with changes in coronary vasoreactivity in obese men

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