Radiobiologie de la curiethérapie

Hennequin, C.; Mazeron, J. J.

doi:10.1016/j.canrad.2013.03.001

Cited by 13 publications

(3 citation statements)

References 25 publications

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“…Dose rate is a major radiobiological parameter of BT, but few studies have evaluated other parameters involved in the differential effects of BT and little data is available regarding the impact of BT on tumor vascularization [ 24 ]. High dose rate-BT (HDR-BT) and pulsed dose rate modalities allow an optimization of dose distribution by varying the dwell times over the different dwell positions [ 25 ]. Low dose rate-BT (LDR-BT) has some radiobiological advantages compared to EBRT: sublethal damage repair during irradiation, leading to a relative protection of healthy tissue; no tumor cell repopulation; cell cycle redistribution; and a low oxygen enhancement ratio [ 25 ].…”

Section: Main Principles Of Ablative Rtmentioning

confidence: 99%

“…High dose rate-BT (HDR-BT) and pulsed dose rate modalities allow an optimization of dose distribution by varying the dwell times over the different dwell positions [ 25 ]. Low dose rate-BT (LDR-BT) has some radiobiological advantages compared to EBRT: sublethal damage repair during irradiation, leading to a relative protection of healthy tissue; no tumor cell repopulation; cell cycle redistribution; and a low oxygen enhancement ratio [ 25 ]. The effect of cancer cell repopulation during protracted irradiation is expected to be negligible for dose rates greater than 0.3 Gy/h [ 24 ].…”

Section: Main Principles Of Ablative Rtmentioning

confidence: 99%

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Stereotactic Ablative Brachytherapy: Recent Advances in Optimization of Radiobiological Cancer Therapy

Xue

Qiu

Wang

et al. 2021

Cancers

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Brachytherapy (BT), a type of focal anti-cancer radiotherapy, delivers a highly focused radiation dose to localized tumors, sparing surrounding normal tissues. Recent technological advances have helped to increase the accuracy of BT and, thus, improve BT-based cancer treatment. Stereotactic ablative brachytherapy (SABT) was designed to improve the ablative effect of radiation, which was achieved via improved image guidance, and calculation of ablative dose, shorter treatment duration, and better organ preservation. Recently collected data characterized SABT as having the potential to cure various early-stage cancers. The method provides higher tumor control rate levels that were previously achievable only by surgical resection. Notably, SABT is suitable for application with unresectable malignancies. However, the pathological assessment of SABT irradiated tumors is limited due to difficulties in specimen acquisition. Prostate, lung, liver, and gynecological cancers are the most commonly reported SABT-treated malignancies. This study will give an overview of SABT, focusing on the advances in SABT optimization, and provide insights on the future benefits of the combined application of SABT with cancer immunotherapies.

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Section: Main Principles Of Ablative Rtmentioning

confidence: 99%

Section: Main Principles Of Ablative Rtmentioning

confidence: 99%

Stereotactic Ablative Brachytherapy: Recent Advances in Optimization of Radiobiological Cancer Therapy

Xue

Qiu

Wang

et al. 2021

Cancers

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“…As the 6 th leading cancer, head and neck (H&N) squamous cell carcinoma accounts for over 600,000 new cancer cases and 350,000 deaths worldwide each year 1,2 . With the advantages of highly localized dose due to rapid dose fall‐off and superior radiobiological effects, 3 brachytherapy plays an important role in treating H&N cancers 4,5 . Recently, intensive investigations were performed to develop new operation procedures based on the guidance of CT imaging and 3D printing template 6–9 and more favorable results were reported in support of the SIBT for recurrent/metastatic H&N cancer 6,7,10,11 …”

Section: Introductionmentioning

confidence: 99%

Automatic planning for head and neck seed implant brachytherapy based on deep convolutional neural network dose engine

Xiao,

Xiong,

Geng

et al. 2023

Medical Physics

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BackgroundSeed implant brachytherapy (SIBT) is an effective treatment modality for head and neck (H&N) cancers; however, current clinical planning requires manual setting of needle paths and utilizes inaccurate dose calculation algorithms.PurposeThis study aims to develop an accurate and efficient deep convolutional neural network dose engine (DCNN‐DE) and an automatic SIBT planning method for H&N SIBT.MethodsA cohort of 25 H&N patients who received SIBT was utilized to develop and validate the methods. The DCNN‐DE was developed based on 3D‐unet model. It takes single seed dose distribution from a modified TG‐43 method, the CT image and a novel inter‐seed shadow map (ISSM) as inputs, and predicts the dose map of accuracy close to the one from Monte Carlo simulations (MCS). The ISSM was proposed to better handle inter‐seed attenuation. The accuracy and efficacy of the DCNN‐DE were validated by comparing with other methods taking MCS dose as reference. For SIBT planning, a novel strategy inspired by clinical practice was proposed to automatically generate parallel or non‐parallel potential needle paths that avoid puncturing bone and critical organs. A heuristic‐based optimization method was developed to optimize the seed positions to meet clinical prescription requirements. The proposed planning method was validated by re‐planning the 25 cases and comparing with clinical plans.ResultsThe absolute percentage error in the TG‐43 calculation for CTV V100 and D90 was reduced from 5.4% and 13.2% to 0.4% and 1.1% with DCNN‐DE, an accuracy improvement of 93% and 92%, respectively. The proposed planning method could automatically obtain a plan in 2.5 ± 1.5 min. The generated plans were judged clinically acceptable with dose distribution comparable with those of the clinical plans.ConclusionsThe proposed method can generate clinically acceptable plans quickly with high accuracy in dose evaluation, and thus has a high potential for clinical use in SIBT.

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