Radiobiological quality of high dose rate interstitial brachytherapy treatments of carcinoma of the cervix

Supe, Sanjay S.; Ganesh, K M; Vaithianathan, Hema; Sankar, B.

doi:10.1016/s1507-1367(06)71045-8

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…Thus, the potential advantage of ISBT in gynecological malignancies could not be clearly demonstrated [ 10 ]. Interstitial implants, two dimensionally planned with semiorthogonal films, were radiobiologically evaluated using a figure of merit (FOM) and biologically effective dose by Supe et al [ 11 ]. Different optimization techniques used in computed tomography based planning were dosimetrically compared in 10 patients by Shwetha et al, in which dose normalization methods were not considered [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment Planning Methods in High Dose Rate Interstitial Brachytherapy of Carcinoma Cervix: A Dosimetric and Radiobiological Analysis

Anbumani¹,

Anchineyan²,

Narayanasamy

et al. 2014

ISRN Oncology

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Treatment planning is a trial and error process that determines optimal dwell times, dose distribution, and loading pattern for high dose rate brachytherapy. Planning systems offer a number of dose calculation methods to either normalize or optimize the radiation dose. Each method has its own characteristics for achieving therapeutic dose to mitigate cancer growth without harming contiguous normal tissues. Our aim is to propose the best suited method for planning interstitial brachytherapy. 40 cervical cancer patients were randomly selected and 5 planning methods were iterated. Graphical optimization was compared with implant geometry and dose point normalization/optimization techniques using dosimetrical and radiobiological plan quality indices retrospectively. Mean tumor control probability was similar in all the methods with no statistical significance. Mean normal tissue complication probability for bladder and rectum is 0.3252 and 0.3126 (P = 0.0001), respectively, in graphical optimized plans compared to other methods. There was no significant correlation found between Conformity Index and tumor control probability when the plans were ranked according to Pearson product moment method (r = −0.120). Graphical optimization can result in maximum sparing of normal tissues.

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Section: Introductionmentioning

confidence: 99%