Radiobiological Investigation of Dose-Rate Effects in Intensity-Modulated Radiation Therapy

Sterzing, Florian; Münter, Marc W.; Schäfer, Mattias; Haering, P.; Rhein, B.; Thilmann, Christoph; Debus, Jürgen

doi:10.1007/s00066-005-1290-1

“…In addition, the IMSRT approach will increase the time for planning, dose delivery and integral dose to the brain [13]. Furthermore, Sterzing et al [38] reported significantly increased survival rates (6%) of human lymphoblasts and melanoma cells in vitro after protracted dose delivery of 2 Gy compared to the usually used high dose rate [38].…”

Section: Late Toxicitymentioning

confidence: 99%

Stereotactic Radiotherapy of Meningiomas

Henzel

¹

,

Groß

²

,

Hamm

³

et al. 2006

View full text Add to dashboard Cite

show abstract

“…It is generally accepted that the trialand-error process typical of conformal planning has shifted inverse planning (IP) to an iterative adjustment of prescription, weights and penalties to obtain the desired dose distribution. Various IP systems are now commercially available, applying quadratic dose-based objective functions, anatomy-based segmentation and segment weighting [8,14,19], or the dynamic penalized likelihood method [16].…”

Section: Introductionmentioning

confidence: 99%

“…It is generally accepted that the trialand-error process typical of conformal planning has shifted inverse planning (IP) to an iterative adjustment of prescription, weights and penalties to obtain the desired dose distribution. Various IP systems are now commercially available, applying quadratic dose-based objective functions, anatomy-based segmentation and segment weighting [8,14,19], or the dynamic penalized likelihood method [16].The determination of prescription parameters of an objective function is a key issue in IP. If a constraint set has been determined for an individual patient, it is not obvious to which extent it holds for an IMRT class solution and whether it is specific to a treatment-planning system (TPS).…”

mentioning

confidence: 99%

Inverse Planning – a Comparative Intersystem and Interpatient Constraint Study

Georg

¹

,

Kroupa

²

,

Georg

³

et al. 2006

View full text Add to dashboard Cite

show abstract

“…In IMRT dose measurements, the dose integration time is often significantly longer than for conventional measurements. [76][77][78][79][80][81] A large fraction of the delivered dose is due to collimator and linear accelerator head leakage, so the dose needs to be measured for all beams, even those radiation beams that do not directly intercept the ionization chamber ͑for example, for serial tomotherapy indices where the chamber position is far from the beam portals͒.…”

Section: Iia3 Electrometer and Cable Performancementioning

confidence: 99%

Dosimetry tools and techniques for IMRT

Low

¹

,

Moran

²

,

Dempsey

³

et al. 2011

View full text Add to dashboard Cite

Intensity modulated radiation therapy ͑IMRT͒ poses a number of challenges for properly measuring commissioning data and quality assurance ͑QA͒ radiation dose distributions. This report provides a comprehensive overview of how dosimeters, phantoms, and dose distribution analysis techniques should be used to support the commissioning and quality assurance requirements of an IMRT program. The proper applications of each dosimeter are described along with the limitations of each system. Point detectors, arrays, film, and electronic portal imagers are discussed with respect to their proper use, along with potential applications of 3D dosimetry. Regardless of the IMRT technique utilized, some situations require the use of multiple detectors for the acquisition of accurate commissioning data. The overall goal of this task group report is to provide a document that aids the physicist in the proper selection and use of the dosimetry tools available for IMRT QA and to provide a resource for physicists that describes dosimetry measurement techniques for purposes of IMRT commissioning and measurement-based characterization or verification of IMRT treatment plans. This report is not intended to provide a comprehensive review of commissioning and QA procedures for IMRT. Instead, this report focuses on the aspects of metrology, particularly the practical aspects of measurements that are unique to IMRT. The metrology of IMRT concerns the application of measurement instruments and their suitability, calibration, and quality control of measurements. Each of the dosimetry measurement tools has limitations that need to be considered when incorporating them into a commissioning process or a comprehensive QA program. For example, routine quality assurance procedures require the use of robust field dosimetry systems. These often exhibit limitations with respect to spatial resolution or energy response and need to themselves be commissioned against more established dosimeters. A chain of dosimeters, from secondary standards to field instruments, is established to assure the quantitative nature of the tests. This report is intended to describe the characteristics of the components of these systems; dosimeters, phantoms, and dose evaluation algorithms. This work is the report of AAPM Task Group 120.

show abstract

Radiobiological Investigation of Dose-Rate Effects in Intensity-Modulated Radiation Therapy

Cited by 53 publications

References 25 publications

Stereotactic Radiotherapy of Meningiomas

Stereotactic Radiotherapy of Meningiomas

Inverse Planning – a Comparative Intersystem and Interpatient Constraint Study

Dosimetry tools and techniques for IMRT

Contact Info

Product

Resources

About