Radioaerosol inhalation lung cine-scintigraphy: a preliminary report.

Estimation of a drug effect by a simplified radioaerosol inhalation lung cine-scintigraphy: Bromhexine on mucociliary clearance mechanisms.

“…The simplified method indicated a very similar evaluation of the effect of bromhexine on airway clearance efficiency with those actually revealed by the original method.airway clearance efficiency ; alveolar deposition ratio ; bromhexine ; mucociliary clearance mechanisms ; radioaerosol inhalation lung cine-scintigraphy Radioaerosol inhalation lung cine-scintigraphy for visualization of mucociliary clearance mechanisms in the lungs and five indexes for quantitative evaluation have facilitated the understanding of mucociliary clearance function in the lungs (Isawa et al 1981(Isawa et al , 1984.In a previous communication we have reported regression functions to estimate the alveolar deposition ratio (ALDR) of inhaled aerosol (Isawa et al 1985). There the ALDR was the amount of radioactivity remaining in the lungs at 24 hr in per cent as compared with the initial radioactivity in the lungs immediately after inhalation of radioactivity ; in other words, lung retention ratio at 24 hr.…”

“…airway clearance efficiency ; alveolar deposition ratio ; bromhexine ; mucociliary clearance mechanisms ; radioaerosol inhalation lung cine-scintigraphy Radioaerosol inhalation lung cine-scintigraphy for visualization of mucociliary clearance mechanisms in the lungs and five indexes for quantitative evaluation have facilitated the understanding of mucociliary clearance function in the lungs (Isawa et al 1981(Isawa et al , 1984.…”

“…There the ALDR was the amount of radioactivity remaining in the lungs at 24 hr in per cent as compared with the initial radioactivity in the lungs immediately after inhalation of radioactivity ; in other words, lung retention ratio at 24 hr. If these regression functions are really usable and clinically applicable, we can shorten the measuring time after aerosol inhalation from 120 min as originally proposed (Isawa et al 1981) to 60 min and do not have to repeat measurement of remaining radioactivity at 24 hr. One of the regression functions applicable both to the patients and normals is ALDR= -48.08+0.47 x FEV1.0%+0.59 X LRR60 which requires as variables only FEV1.0% or forced expiratory volume in one sec divided by forced expiratory volume in per cent and LRR60 or lung retention ratio at 60 min (Isawa et al 1985).…”

Mucociliary clearance mechanism in interstitial lung disease.

“…Fourteen patients (11 men and 3 women, the mean age 61, range 30 to 73) with pulmonary interstitial fibrosis and 8 patients (6 men and 2 women, the mean age 40, range 24 to 61) with sarcoidosis were studied by lung function tests and radioaerosol inhalation lung cine-scintigraphy (Isawa et al 1981(Isawa et al , 1984a. The diagnosis of the former was based on clinical and chest x-ray findings and lung function data ; namely, generalized increased , interstitial densities consisting of fine to coarse reticulonodular shadows with or without coarse curvilinear densities or honey-combing on chest radiograms (Frazer 1982;Kerr 1984) Received July 2, 1985; accepted for publication November 28, 1985.…”

“…In obstructive airways disease mucociliary clearance mechanisms are known to be extensively deranged (Isawa et al 1981(Isawa et al , 1984a.…”