Radioactive seed localization in breast cancer treatment

Janssen, Natasja; Nijkamp, Jasper; Alderliesten, Tanja; Loo, Claudette E.; Rutgers, Emiel J. T.; Sonke, Jan‐Jakob; Peeters, Marie‐Jeanne T. F. D. Vrancken

doi:10.1002/bjs.9962

Cited by 50 publications

(30 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Catharina Hospital had one of the lowest positive margin rates, 4.6% (15/325) with RSL, but there was no corresponding WL group (Van Riet et al, 2010). The Netherlands Cancer Institute (Janssen, et al, 2016) reported positive margin rates with RSL as 9.1% for DCIS and 9.7% for invasive cancer, but likewise there was not a comparison WL group. A Canadian multicenter randomized trial also favorably compared RSL to WL, with positive margin rates of 10.5% for the 152 RSL patients and 11.8% for the 153 WL patients (Lovrics, et al, 2011).…”

Section: Discussionmentioning

confidence: 95%

Initial Community Hospital Performance of Radioactive Seed Localization for Breast Cancer Patients

Wheeler¹,

Liu²

2017

CCO

View full text Add to dashboard Cite

Purpose: To compare the positive margin rates for women with nonpalpable breast tumors who underwent breast conserving surgery with wire localization versus those with radioactive seed localization in a small community hospital and to compare the size of the corresponding breast specimens. Introduction:Wire localization (WL) has been the standard technique to assist in the removal of nonpalpable breast tumors for the past three decades for patients undergoing breast conserving surgery. Radioactive seed localization (RSL) is an alternative technique that provides advantages of patient comfort and scheduling convenience. There are numerous studies from large academic centers, but little information on how successfully this technique can be implemented in community hospitals. Results: Three of the 35 WL patients (8.5%) had a positive margin compared to 14 of the 110 RSL patients (12.7%), but this difference was not statistically significant (p-value 0.763). The breast specimen weight had a geometric mean of 30.26 g for the WL patients and 32.78 g for the RSL patients, a difference of 8.3%, which was not statistically significant. Positive margin rates did not depend on the surgeon or the radiologist placing the I-125 localization seed. Conclusion:The RSL technique can be implemented in community hospitals with the expectation of having the same positive margin rates as reported from academic centers.

show abstract

Section: Discussionmentioning

confidence: 95%

Initial Community Hospital Performance of Radioactive Seed Localization for Breast Cancer Patients

Wheeler¹,

Liu²

2017

CCO

View full text Add to dashboard Cite

show abstract

“…However, TCC is much less prone to dislocate compared to other markers, and in our series no lesion missing occurred . Recently, promising results emerged from evaluation of RSL and magnetic seeds, since they conjugate the advantage of an intraoperative guide such as ROLL, with the high accuracy of localization and easier logistics associated to TCC …”

Section: Discussionmentioning

confidence: 99%

Radio‐guided and clip‐guided preoperative localization for malignant microcalcifications offer similar performances in breast‐conserving surgery

et al. 2019

View full text Add to dashboard Cite

Obtaining a tailored breast resection is challenging in microcalcifications detected on screening mammography, and an accurate localization is required. The aim of this study was to compare the efficacy of radio‐guided localization (ROLL) versus ultrasound localization of a titanium clip with collagen (TCC) in terms of clear margins, re‐intervention rates, excess of resected breast tissue, and operative times in pure malignant microcalcifications detected on screening mammography. Two hundred and twenty‐one consecutive patients with malignant microcalcifications detected on screening mammography from a tertiary breast unit were reviewed: 177 patients were localized by TCC and 44 patients by stereotactic ROLL. A propensity score‐matched analysis was performed, followed by a logistic regression model, to avoid selection bias. Adequacy of resection was expressed as the calculated resection ratio considering lesion size. No differences were found in clear margins with ROLL versus TCC (77.3% vs 81.8%, adjusted OR 2, P = 0.27). Re‐operation rates were similar, being 11.3% with ROLL and 7.4% with TCC (P = 0.627). Mean resection volume was 46.2 cm3 with ROLL versus 54.2 cm3 with TCC (P = 0.222). Adjusted mean calculated resection ratio was 1.8 with ROLL and 2.1 with TCC (P = 0.38). Surgery time was longer with TCC compared to ROLL (69.6 vs 52.7 minutes, P < 0.0001). ROLL and TCC are equally effective to excise malignant microcalcifications with clear margins, providing similar re‐intervention rates and resection volumes.

show abstract

“…With the increasing quality of mammographic imaging and the introduction of wide-ranging screening campaigns for breast cancer, non-palpable tumors are detected earlier and to a higher degree [1][2][3]. Consequently, breast conserving surgery (lumpectomy) has become an attractive option compared to whole-breast surgery (mastectomy) [3].…”

Section: Introductionmentioning

confidence: 99%

“…This can be explained by the excision procedure of non-palpable tumors, which is highly dependent on accurate target delineation (pre-localization) needed for surgical guidance [1,2,5]. There is a clear need for improved preoperative image-guided localization in order to improve resection and recurrence rates [1,5].…”

Section: Introductionmentioning

confidence: 99%

Injectable iodine-125 labeled tissue marker for radioactive localization of non-palpable breast lesions

et al. 2018

View full text Add to dashboard Cite

A new type of tissue marker for local administration to non-palpable breast tumors has been developed. The surgical guidance marker is based on derivatives of the biomaterial sucrose acetate isobutyrate and unlike currently used markers it is injectable in the tissue using thin needles, reducing the discomfort to the patients significantly. The marker confers CT contrast and has radioactive properties, meaning it also could find use in brachytherapy. The design of the iodine-125 labeled fiducial tissue marker enables control of dosimetry as well as a choice of iodine isotope used. The marker is anticipated to be clinical applicable due to its contrast performance in mice and its potential for enhanced flexibility in surgical procedures, compared to current methods.

show abstract

Radioactive seed localization in breast cancer treatment

Cited by 50 publications

References 52 publications

Initial Community Hospital Performance of Radioactive Seed Localization for Breast Cancer Patients

Initial Community Hospital Performance of Radioactive Seed Localization for Breast Cancer Patients

Radio‐guided and clip‐guided preoperative localization for malignant microcalcifications offer similar performances in breast‐conserving surgery

Injectable iodine-125 labeled tissue marker for radioactive localization of non-palpable breast lesions

Contact Info

Product

Resources

About