Radioactive Gold Nanoparticles in Cancer Therapy: Therapeutic Efficacy Studies of GA-198AuNP Nanoconstruct in Prostate Tumor-Bearing Mice

Renaissance of nuclear medicine through green nanotechnology: functionalized radioactive gold nanoparticles in cancer therapy—my journey from chemistry to saving human lives

“…In this context, we explored the application of EGCG, a polyphenol from tea, as a reducing agent to transform gold salt into gold nanoparticles (Fig. 2) [6][7][8][9][10]. Our experiments revealed that the redox potential of EGCG is ideal to produce gold nanoparticles in quantitative yields through this unprecedented green nanotechnology process [6][7][8][9][10].…”

“…We therefore attempted to utilize ''Katti Peptides' to reduce gold salt to the corresponding nanoparticles [28]. As this new approach to gold nanotechnology worked to excellent efficacy in terms of yield, reproducibility and biocompatibility, we then focused our attention to produce the corresponding radioactive gold nanoparticles using Au-198 radioactive precursors produced within the University of Missouri Nuclear Reactor (MURR) [5][6][7][8][9][10]. It is important to recognize that the traditional methods of reactions of sodium borohydride with Au-198 salts failed to give Au-198 nanoparticles in good yields with high reproducibility.…”

“…1. In collaboration with Dr. Cutler, University of Missouri Research Reactor irradiation and quality control facilities were used for the production of Au-198 precursor which was subsequently converted into the corresponding radioactive gold nanoparticles [5][6][7][8][9][10]. In order to slow/eliminate agglomeration of Au-198 nanoparticles, GAP was employed to encapsulate the radioactive nanoparticles.…”

“…Immense clinical advantages can be derived through the dissipation of the potential energy associated with the high positive charge and its neutralization occurring concomitantly leading to localized tumor therapeutic effects. Our series of recent studies have already generated extensive therapeutic efficacy data from the treatment of tumors in mice and tumor bearing dogs (where the disease mimics human cancers) [5][6][7][8][9][10].…”

Preparation and characterization of chitosan-capped radioactive gold nanoparticles: neutron irradiation impact on structural properties

“…The radioisotope of gold-198 with a half-life of 2.7 days can generate a β-particle with a maximum energy of 960 keV (99 %) suitable for therapeutic applications and a 412 keV (95.6 %) γ-ray for gamma imaging or single photon emission computed tomography (SPECT). In recent years, nanoparticles based on β-emitter radioisotopes of gold appear to be a promising approach for improved cancer treatment [11][12][13][14][15]. Surface engineering of nanoparticles plays a major role in their colloidal stability and biological properties [16].…”