Radioablation of Hepatic Metastases from Renal Cell Carcinoma With Image-guided Interstitial Brachytherapy

Omari, Jazan; Heinze, Constanze; Damm, Robert; Hass, Peter; Janitzky, Andreas; Wendler, Johann Jakob; Seidensticker, Max; Ricke, Jens; Powerski, Maciej; Pech, Maciej

doi:10.21873/anticanres.13370

Cited by 6 publications

(5 citation statements)

References 35 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LC and OS rates were 88.7%, 70.7% and 96.7%, 79.6% at 6 and 12 months respectively (45). Omari et al investigated the results of 14 patients with 54 renal cell liver metastases, treated with liver BT, reporting LC rate of 92.6% at 10.1 months and median OS of 51.2 months (62).…”

Section: Clinical Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Narrative Review of High-Dose-Rate Interstitial Brachytherapy in Primary or Secondary Liver Tumors

et al. 2022

View full text Add to dashboard Cite

The optimal management of intrahepatic malignancies involves a multidisciplinary approach. Although surgical resection has been considered the only curative approach, the use of several minimally invasive ablative techniques has dramatically increased the last two decades, mainly due to the fact that they provide similar oncological results with significantly decreased morbidity. Among these modalities, interstitial liver brachytherapy, probably the most flexible liver ablative method, with excellent clinical data on its safety and effectiveness, is frequently not even mentioned as an option in the current peer reviewed literature and guidelines. Brachytherapy is a type of radiotherapy utilizing radionuclides that are directly inserted into the tumor. Compared to external beam radiation therapy, brachytherapy has the potential to deliver an ablative radiation dose over a short period of time, with the advantage of a rapid dose fall-off, that allows for sparing of adjacent healthy tissue. For numerous malignancies such as skin, gynecological, breast, prostate, head and neck, bladder, liver and soft-tissue tumors, brachytherapy as a monotherapy or combined with external beam radiation therapy, has become a standard treatment for many decades. This review article aims to describe the high-dose-rate liver brachytherapy technique, its selection criteria, present its advantages and disadvantages, as well as the available clinical data, in order to help physicians to explore and hopefully introduce liver brachytherapy into their clinical routine.

show abstract

Section: Clinical Resultsmentioning

confidence: 99%

“…Omari et al. investigated the results of 14 patients with 54 renal cell liver metastases, treated with liver BT, reporting LC rate of 92.6% at 10.1 months and median OS of 51.2 months ( 62 ).…”

Section: Techniquementioning

confidence: 99%

Narrative Review of High-Dose-Rate Interstitial Brachytherapy in Primary or Secondary Liver Tumors

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Local ablation methods such as radiofrequency ablation, microwave ablation, and interstitial brachytherapy are an emerging treatment arm in liver malignancies. The literature on liver metastasectomy for RCC is still sparse, with the available studies showing comparable results to surgical resection (9,43,44). Local ablative therapies might be suitable for patients not amenable to surgical or medical treatments (43).…”

Section: Discussionmentioning

confidence: 99%

“…Interventional technique. IBT was performed as previously reported (9,10). All procedures were performed under analgosedation.…”

Section: Methodsmentioning

confidence: 99%

“…For patients not eligible for surgical resection, e.g., due to poor performance status, local therapy of liver metastases is a viable option. Treatment methods include radiofrequency ablation, cryotherapy, or interstitial brachytherapy (iBT) (9). Contrary to thermal ablation techniques, computed tomography (CT)-or magnetic resonance (MR)-guided iBT has no technical restrictions regarding lesion size or proximity to critical anatomical structures.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation