Radio-sensitizing effect of a cocktail of phytochemicals on HepG2 cell proliferation, motility and survival

Abdraboh, Mohamed E.; Essa, Zaidoon Shaker; Abdelrazzak, Abdelrazek B.; El-Far, Yousra M.; Elsherbini, Yasser; El-Zayat, Mustafa; Ali, Doaa A.

doi:10.1016/j.biopha.2020.110620

Cited by 10 publications

(5 citation statements)

References 40 publications

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“…It is known that Se metabolism in the brain differs from metabolism in other organs, because it is predominantly preserved in the brain in the presence of selenium deficiency [ 75 , 76 ]. In recent decades, the role of SeNP in neurological diseases has been actively studied ( Table 2 , Figure 2 ), since neurons are especially vulnerable to damage caused by oxidative stress for a number of reasons, such as high oxygen consumption (approximately 25% of total body consumption), the presence of a large amount of polyunsaturated fatty acids, and low levels of antioxidant enzymes [ 77 , 78 , 79 ].…”

Section: The Role Of Senp In Medicine and Human Healthmentioning

confidence: 99%

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

Varlamova

Turovsky

Блинова

2021

IJMS

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This review presents the latest data on the importance of selenium nanoparticles in human health, their use in medicine, and the main known methods of their production by various methods. In recent years, a multifaceted study of nanoscale complexes in medicine, including selenium nanoparticles, has become very important in view of a number of positive features that make it possible to create new drugs based on them or significantly improve the properties of existing drugs. It is known that selenium is an essential trace element that is part of key antioxidant enzymes. In mammals, there are 25 selenoproteins, in which selenium is a key component of the active site. The important role of selenium in human health has been repeatedly proven by several hundred works in the past few decades; in recent years, the study of selenium nanocomplexes has become the focus of researchers. A large amount of accumulated data requires generalization and systematization in order to improve understanding of the key mechanisms and prospects for the use of selenium nanoparticles in medicine, which is the purpose of this review.

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Section: The Role Of Senp In Medicine and Human Healthmentioning

confidence: 99%

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

Varlamova

Turovsky

Блинова

2021

IJMS

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“…The continuing search for new antitumor natural compounds is a promising avenue for its prevention or treatment [6]. Plant compounds such as alkaloids, phenolics, flavonoids, phenyl-propanoids, and terpenoids have also been reported to have anticancer activity [7,8].…”

Section: Introductionmentioning

confidence: 99%

The Antimicrobial, Antioxidant, and Anticancer Activity of Greenly Synthesized Selenium and Zinc Composite Nanoparticles Using Ephedra aphylla Extract

et al. 2021

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The current work aimed to synthesize selenium and zinc nanoparticles using the aqueous extract of Ephedra aphylla as a valuable medicinal plant. The prepared nanoparticles were characterized by TEM, zeta potential, and changes in the phytochemical constituents. Hence, the phenolic, flavonoid, and tannin contents were reduced in the case of the prepared samples of nanoparticles than the original values in the aqueous extract. The prepared extract of Ephedra aphylla and its selenium and zinc nanoparticles showed high potency as antioxidant agents as a result of the DPPH• assay. The samples were assessed as anticancer agents against six tumor cells and a normal lung fibroblast (WI-38) cell line. The selenium nanoparticles of Ephedra aphylla extract revealed very strong cytotoxicity against HePG-2 cells (inhibitory concentration (IC50) = 7.56 ± 0.6 µg/mL), HCT-116 cells (IC50 = 10.02 ± 0.9 µg/mL), and HeLa cells (IC50 = 9.23 ± 0.8 µg/mL). The samples were evaluated as antimicrobial agents against bacterial and fungal strains. Thus, selenium nanoparticles showed potent activities against Gram-negative strains (Salmonella typhimurium, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli), Gram-positive strains (Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus, and Staphylococcus epidermidis), and the fungal strain Candida albicans. In conclusion, the preparation of nanoparticles of either selenium or zinc is crucial for improved biological characteristics.

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“…Studies proved that the metabolism of Se in the brain is different from that in other body organs, as Se remains preserved in the brain in the case of Se deficiency [ 55 , 56 , 57 ]. Currently, SeNPs’ role in brain diseases has been studied because neurons are more prone to be damaged by oxidative stress due to several reasons, such as a low level of antioxidant enzymes, a high consumption of oxygen, and occupancy of the high level of polyunsaturated fats [ 58 , 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

Latent Potential of Multifunctional Selenium Nanoparticles in Neurological Diseases and Altered Gut Microbiota

et al. 2023

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Neurological diseases remain a major concern due to the high world mortality rate and the absence of appropriate therapies to cross the blood–brain barrier (BBB). Therefore, the major focus is on the development of such strategies that not only enhance the efficacy of drugs but also increase their permeability in the BBB. Currently, nano-scale materials seem to be an appropriate approach to treating neurological diseases based on their drug-loading capacity, reduced toxicity, targeted delivery, and enhanced therapeutic effect. Selenium (Se) is an essential micronutrient and has been of remarkable interest owing to its essential role in the physiological activity of the nervous system, i.e., signal transmission, memory, coordination, and locomotor activity. A deficiency of Se leads to various neurological diseases such as Parkinson’s disease, epilepsy, and Alzheimer’s disease. Therefore, owing to the neuroprotective role of Se (selenium) nanoparticles (SeNPs) are of particular interest to treat neurological diseases. To date, many studies investigate the role of altered microbiota with neurological diseases; thus, the current review focused not only on the recent advancement in the field of nanotechnology, considering SeNPs to cure neurological diseases, but also on investigating the potential role of SeNPs in altered microbiota.

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Radio-sensitizing effect of a cocktail of phytochemicals on HepG2 cell proliferation, motility and survival

Cited by 10 publications

References 40 publications

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

The Antimicrobial, Antioxidant, and Anticancer Activity of Greenly Synthesized Selenium and Zinc Composite Nanoparticles Using Ephedra aphylla Extract

Latent Potential of Multifunctional Selenium Nanoparticles in Neurological Diseases and Altered Gut Microbiota

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