Radio-Induced Lesion in Normal Tissues

Pasquier, David; Schmutz, Jörg; Lartigau, É.

doi:10.1007/1-4020-4448-8_19

Cited by 7 publications

(7 citation statements)

References 216 publications

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“…It is known that hyperbaric oxygen treatment (HBOT) induces neoangiogenesis in irradiated tissue in animal models,15 and it also has been indicated in clinical studies 16, 17. HBOT is an accepted and effective treatment for hypovascular radiation damage, such as radiation ulcers and cystitis 18, 19. However, the effect of HBOT on chronic brain damage after neurosurgery and RT in adult patients with brain tumors rarely has been investigated 18.…”

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confidence: 99%

Hyperbaric oxygen treatment improved neurophysiologic performance in brain tumor patients after neurosurgery and radiotherapy

Schellart

Reits

Kleij

et al. 2011

Cancer

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BACKGROUND:Cognitive performance often is impaired permanently in long-term brain tumor survivors after neurosurgery and radiotherapy. Hyperbaric oxygen treatment (HBOT) stimulates neovascularization of hypoperfused tissue and may result in improved functionality of damaged tissue. In this pilot study, clinical neurophysiologic tests were used to assess the effect of HBOT on brain performance. METHODS: Ten long-term brain tumor survivors received HBOT for severe cognitive deficits after neurosurgery and radiosurgery. Patients were tested before HBOT and at 6 weeks and 4 months after HBOT. The tests comprised a quantitative electroencephalographic (EEG) examination, the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for memory performance, and 2 cognitive tests, the number connection test (NCT) and the continuous reaction time test (CRTT). Late event-related components (LERCs) of averaged evoked EEG responses to a visual odd-ball stimulus were analyzed from whole-head activity maps. For comparison, a control group of healthy individuals (no HBOT) also were investigated. RESULTS: After HBOT, the amplitude of the LERC with the longest latency, P3b (involved in object interpretation) was improved significantly (P ¼ .02). The amplitudes of the N200 (occipital, negative) and the intermediate P3a (centroparietal, positive), LERCs with shorter latencies, and of a small, positive, occipital visual component did not change. Neither latencies nor reaction times changed after HBOT. However, P3a and P3b (parietal, positive) latencies were longer in survivors than in healthy individuals. The NCT produced inconclusive results, but the IQCODE revealed an improvement. When outcomes of the NCT, CRTT, IQCODE, and P3b amplitudes were evaluated in common tests, HBOT appeared to provide substantial improvement (P<.006). CONCLUSIONS: On the basis of the current results, the authors concluded tentatively that HBOT improves neurophysiologic performance in long-term brain tumor survivors.

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mentioning

confidence: 99%

Hyperbaric oxygen treatment improved neurophysiologic performance in brain tumor patients after neurosurgery and radiotherapy

Schellart

Reits

Kleij

et al. 2011

Cancer

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“…Currently, the ECHM recommends HBOT for the treatment of RP (degree of recommendation I/ level of evidence B)[ 22 ]. Unlike most conventional treatment that only alleviated symptoms, HBOT can favourably change the natural history of other RT late sequelae[ 4 ]. Its clinical benefit emanates from the therapeutic effects of hyperbaric oxygen that include, among others, the promotion of tissue oxygenation, neovascularisation, reepithelialisation, and the reversal of the fibroatrophic process induced by ionising radiation[ 16 , 21 , 41 , 42 ].…”

Section: Hbotmentioning

confidence: 99%

“…, haematochezia, diarrhoea, tenesmus, abdominal pain) and in a cause-effect relationship of previous history of pelvic RT. The diagnosis can be confirmed by endoscopy with or without histologic examination, as imaging findings are usually nonspecific[ 4 - 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…The beneficial properties of hyperbaric oxygen, together with the growing knowledge about the pathophysiology of delayed radiation injuries, have led to the use of hyperbaric oxygen therapy (HBOT) in the treatment of RP[ 4 ]. Currently, HBOT is considered by the European Committee for Hyperbaric Medicine (ECHM) as a treatment modality for late radio-induced lesions, namely, the prevention and treatment of osteoradionecrosis of the mandible, haemorrhagic radiation cystitis and RP (degree of recommendation I/level of evidence B).…”

Section: Introductionmentioning

confidence: 99%

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Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis: Useless or useful? – A literature review

Costa¹,

Amaro

Nunes³

et al. 2021

WJG

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Radiotherapy (RT) is the backbone of multimodality treatment of more than half of cancer cases. Despite new modern RT techniques, late complications may occur such as radiation proctitis (RP). The natural history of RP is unpredictable. Minor symptoms may resolve spontaneously or require conservative treatment. On the other hand, for similar and uncomplicated clinical contexts, symptoms may persist and can even be refractory to the progressive increase in treatment measures. Over the last decades, an enormous therapeutic armamentarium has been considered in RP, including hyperbaric oxygen therapy (HBOT). Currently, the evidence regarding the impact of HBOT on RP and its benefits is conflicting. Additional prospective and randomised studies are necessary to validate HBOT’s effectiveness in the ‘real world’ clinical practice. This article reviewed the relevant literature on pathophysiology, clinical presentation, different classifications and discuss RP management including a proposal for a therapeutic algorithm with a focus on HBOT.

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“…HBOT has been a very successful adjunct in the management of late complications of radiotherapy. [ 20 ] Typically, in mandibular reconstruction, in an irradiated field, HBOT has been found to markedly improve outcomes after composite reconstruction. HBOT has been particularly beneficial in the management of mandibular osteoradionecrosis.…”

Section: Applications In Plastic Surgerymentioning

confidence: 99%

Hyperbaric oxygen and wound healing

Bhutani¹,

Vishwanath

2012

Indian J Plast Surg

122

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Hyperbaric oxygen therapy (HBOT) is the use of 100% oxygen at pressures greater than atmospheric pressure. Today several approved applications and indications exist for HBOT. HBOT has been successfully used as adjunctive therapy for wound healing. Non-healing wounds such as diabetic and vascular insufficiency ulcers have been one major area of study for hyperbaric physicians where use of HBOT as an adjunct has been approved for use by way of various studies and trials. HBOT is also indicated for infected wounds like clostridial myonecrosis, necrotising soft tissue infections, Fournier's gangrene, as also for traumatic wounds, crush injury, compartment syndrome, compromised skin grafts and flaps and thermal burns. Another major area of application of HBOT is radiation-induced wounds, specifically osteoradionecrosis of mandible, radiation cystitis and radiation proctitis. With the increase in availability of chambers across the country, and with increasing number of studies proving the benefits of adjunctive use for various kinds of wounds and other indications, HBOT should be considered in these situations as an essential part of the overall management strategy for the treating surgeon.

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Radio-Induced Lesion in Normal Tissues

Cited by 7 publications

References 216 publications

Hyperbaric oxygen treatment improved neurophysiologic performance in brain tumor patients after neurosurgery and radiotherapy

Hyperbaric oxygen treatment improved neurophysiologic performance in brain tumor patients after neurosurgery and radiotherapy

Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis: Useless or useful? – A literature review

Hyperbaric oxygen and wound healing

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