Radio-immunoconjugated, Dox-loaded, surface-modified superparamagnetic iron oxide nanoparticles (SPIONs) as a bioprobe for breast cancer tumor theranostics

Zolata, Hamidreza; Afarideh, H.; Davani, F. Abbasi

doi:10.1007/s10967-014-3101-6

Cited by 14 publications

(4 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Doxorubicin (DOX) is a commonly used anticancer drug which has been widely used in a variety of cancer chemotherapy, such as blood malignant tumor [1], a variety of adenocarcinoma [2][3][4][5], soft tissue sarcoma [6], and so on. However, long term and high dosages of DOX will lead to drug resistance [7], nausea [8], hair loss [9], and acute and chronic toxicity [10], which may lead to congestive heart failure [11].…”

Section: Introductionmentioning

confidence: 99%

One-step, Rapid and Green Synthesis of Multifunctional Gold Nanoparticles for Tumor-Targeted Imaging and Therapy

et al. 2020

View full text Add to dashboard Cite

Gold nanoparticles (GNPs) have always been used as doxorubicin (DOX) transport vectors for tumor diagnosis and therapy; however, the synthesis process of these vectors is to prepare GNPs via chemical reduction method firstly, followed by conjugation with DOX or specific peptides, so these meth•ods faced some common problems including multiple steps, high cost, time consuming, complicated preparation, and post-processing. Here, we present a one-step strategy to prepare the DOX-conjugated GNPs on the basis of DOX's chemical constitution for the first time. Moreover, we prepare a multifunctional GNPs (DRN-GNPs) with a one-step method by the aid of the reductive functional groups possessed by DOX, RGD peptides, and nuclear localization peptides (NLS), which only needs 30 min. The results of scattering images and cell TEM studies indicated that the DRN-GNPs could target the Hela cells' nucleus. The tumor inhibition rates of DRN-GNPs via tumor and tail vein injection of nude mice were 66.7% and 57.7%, respectively, which were significantly enhanced compared to control groups. One step synthesis of multifunctional GNPs not only saves time, materials, but also it is in line with the development direction of green chemistry, and it would lay the foundation for large-scale applications within the near future. Our results suggested that the fabrication strategy is efficient, and our prepared DRN-GNPs possess good colloidal stability in the physiological system; they are a potentially contrast agent and an efficient DOX transport vector for cervical cancer diagnosis and therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

One-step, Rapid and Green Synthesis of Multifunctional Gold Nanoparticles for Tumor-Targeted Imaging and Therapy

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These modifi cations lead to escape of SPIONs from RES. Comparing to our previous 64 Cu-labeled, antibody conjugated magnetic nanoparticles experiment [27], tumor uptake and tumor/liver, tumor/ kidney, tumor/blood ratios decreased from 12.5 ± 1.2%, 1.32 ± 0.10%, 1.83 ± 0.14%, 4.63 ± 0.64% to 5.29 ± 0.49%, 1.03 ± 0.08%, 1.15 ± 0.18%, 3.08 ± 0.67% at 24 h postinjection. Although tumor/organs ratios and tumor uptakes are smaller than antibody--conjugated SPIONs, folic acid-coated SPIONs are less expensive and can be prepared with relative ease.…”

Section: Discussionmentioning

confidence: 74%

Synthesis and evaluation of radiolabeled, folic acid-PEG conjugated, amino silane coated magnetic nanoparticles in tumor bearing Balb/C mice

et al. 2015

Self Cite

View full text Add to dashboard Cite

Abstract. To design a potent agent for positron emission tomography/magnetic resonance imaging (PET/MRI) imaging and targeted magnetic hyperthermia-radioisotope cancer therapy radiolabeled surface modifi ed superparamagnetic iron oxide nanoparticles (SPIONs) were used as nanocarriers. Folic acid was conjugated for increasing selective cellular binding and internalization through receptor-mediated endocytosis. SPIONs were synthesized by the thermal decomposition of tris (acetylacetonato) iron (III) to achieve narrow and uniform nanoparticles. To increase the biocompatibility of SPIONs, they were coated with (3-aminopropyl) triethoxysilane (APTES), and then conjugated with synthesized folic acid-polyethylene glycol (FA-PEG) through amine group of (3-aminopropyl) triethoxysilane. Finally, the particles were labeled with 64 Cu (t 1/2 = 12.7 h) using 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid mono (N-hydroxy succinimide ester) DOTA-NHS chelator. After the characterization of SPIONs, their cellular internalization was evaluated in folate receptor (FR) overexpressing KB (established from a HeLa cell contamination) and mouse fi broblast cell (MFB) lines. Eventually, active and passive targeting effects of complex were assessed in KB tumor-bearing Balb/C mice through biodistribution studies. Synthesized bare SPIONs had low toxicity effect on healthy cells, but surface modifi cation increased their biocompatibility. Moreover, KB cells viability was reduced when using folate conjugated SPIONs due to FR-mediated endocytosis, while having little effect on healthy cells (MFB). Moreover, this radiotracer had tolerable in vivo characteristics and tumor uptake. In the receptor blocked case, tumor uptake was decreased, indicating FR-specifi c uptake in tumor tissue while enhanced permeability and retention effect was major mechanism for tumor uptake.

show abstract

“…[600] The emerging advances in nanotechnology have offered the possibility to develop mAb-based multifunctional nanoparticle delivery platforms for obtaining optimized pharmacokinetic profiles and expanded therapeutic capabilities compared with free anti-CD mAbs. [601,602]…”

Section: Cluster Of Differentiation Moleculesmentioning

confidence: 99%

Antibody‐Incorporated Nanomedicines for Cancer Therapy

Chen

2022

Advanced Materials

View full text Add to dashboard Cite

show abstract

Radio-immunoconjugated, Dox-loaded, surface-modified superparamagnetic iron oxide nanoparticles (SPIONs) as a bioprobe for breast cancer tumor theranostics

Cited by 14 publications

References 15 publications

One-step, Rapid and Green Synthesis of Multifunctional Gold Nanoparticles for Tumor-Targeted Imaging and Therapy

One-step, Rapid and Green Synthesis of Multifunctional Gold Nanoparticles for Tumor-Targeted Imaging and Therapy

Synthesis and evaluation of radiolabeled, folic acid-PEG conjugated, amino silane coated magnetic nanoparticles in tumor bearing Balb/C mice

Antibody‐Incorporated Nanomedicines for Cancer Therapy

Contact Info

Product

Resources

About