Radio guided occult lesion localization (ROLL) for non‐palpable invasive breast cancer

Esser, Stijn van; Hobbelink, Monique G.G.; Ploeg, Iris M. C. van der; Mali, Wptm; Diest, Paul J. van; Rinkes, Inne H.M. Borel; Hillegersberg, Richard van

doi:10.1002/jso.21143

Cited by 36 publications

(16 citation statements)

References 32 publications

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“…After intratumoral injection, more of the internal mammary chain LNs can be found thereby affecting the adjuvant therapeutic plan and possibly long-term survival [ 17 , 18 ]. In addition, injecting intratumorally allows lumpectomy with the radioguided occult lesion localization (ROLL) technique in the same procedure [ 19 – 21 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of a 1-day and a 2-day protocol for lymphatic mapping and sentinel lymph node biopsy in patients with nonpalpable breast cancer

Esser

Hobbelink

Isselt

et al. 2009

Eur J Nucl Med Mol Imaging

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Purpose To compare the identification rate of the sentinel node in a 1-day protocol versus a 2-day protocol in patients with a nonpalpable breast carcinoma. Methods In the 1-day protocol an average dose of 120 MBq 99m Tc-nanocolloid was injected intratumorally on the day of surgery, and in the 2-day protocol an average dose of 370 MBq 99m Tc-nanocolloid was injected intratumorally the day before surgery. Both a gamma ray detection probe and patent blue were used to locate the sentinel node. Results In 57 of 67 patients (85%) treated in the 1-day protocol and in 51 of 56 patients (91%) treated in the 2-day protocol the sentinel node was detected (p=0.311). Of the patients in the 1-day protocol and the 2-day protocol, respectively, 18 (27%) and 13 (23%) showed metastasis (p=0.975) Conclusion There was no significant difference in the identification rate of the sentinel node between the 1-day protocol and the 2-day protocol in patients diagnosed with a nonpalpable breast carcinoma.

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Section: Discussionmentioning

confidence: 99%

Comparison of a 1-day and a 2-day protocol for lymphatic mapping and sentinel lymph node biopsy in patients with nonpalpable breast cancer

Esser

Hobbelink

Isselt

et al. 2009

Eur J Nucl Med Mol Imaging

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“…Rampaul et al concluded that ROLL was less painful for the patient and was an easier technique to perform surgically 107. Furthermore, the ROLL procedure could be combined with lymphatic mapping and sentinel lymph node biopsy, which makes it more patient-friendly compared with WGL 112,115. ROLL was reported to significantly reduce pre- and intraoperative localization time of nonpalpable breast tumors 3.…”

Section: Future Directionsmentioning

confidence: 99%

Obtaining Adequate Surgical Margins in Breast-Conserving Therapy for Patients with Early-Stage Breast Cancer: Current Modalities and Future Directions

et al. 2009

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Inadequate surgical margins represent a high risk for adverse clinical outcome in breast-conserving therapy (BCT) for early-stage breast cancer. The majority of studies report positive resection margins in 20% to 40% of the patients who underwent BCT. This may result in an increased local recurrence (LR) rate or additional surgery and, consequently, adverse affects on cosmesis, psychological distress, and health costs. In the literature, various risk factors are reported to be associated with positive margin status after lumpectomy, which may allow the surgeon to distinguish those patients with a higher a priori risk for re-excision. However, most risk factors are related to tumor biology and patient characteristics, which cannot be modified as such. Therefore, efforts to reduce the number of positive margins should focus on optimizing the surgical procedure itself, because the surgeon lacks real-time intraoperative information on the presence of positive resection margins during breast-conserving surgery. This review presents the status of pre- and intraoperative modalities currently used in BCT. Furthermore, innovative intraoperative approaches, such as positron emission tomography, radioguided occult lesion localization, and near-infrared fluorescence optical imaging, are addressed, which have to prove their potential value in improving surgical outcome and reducing the need for re-excision in BCT.

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“…The simplest methods consist in implanting a foreign object ͑hook, clip, or gold rod 2 ͒ or injecting a marker near or inside the tumor. 3,4 These invasive procedures require puncturing the skin and are limited to accessible locations. Moreover, guiding tools do not determine the outline of the tumor, but rather its approximate position.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound internal tattooing

et al. 2011

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Radio guided occult lesion localization (ROLL) for non‐palpable invasive breast cancer

Abstract: The ROLL procedure seems to be an alternative to WGL in patients with non-palpable breast carcinoma. To determine the place of ROLL versus WGL in the treatment of non-palpable breast cancer, a randomized clinical trial is needed.

Cited by 36 publications

References 32 publications

Comparison of a 1-day and a 2-day protocol for lymphatic mapping and sentinel lymph node biopsy in patients with nonpalpable breast cancer

Comparison of a 1-day and a 2-day protocol for lymphatic mapping and sentinel lymph node biopsy in patients with nonpalpable breast cancer

Obtaining Adequate Surgical Margins in Breast-Conserving Therapy for Patients with Early-Stage Breast Cancer: Current Modalities and Future Directions

Ultrasound internal tattooing

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