Radio frequency quadrupole technology: Evolution and contributions to mass spectrometry

March, Raymond E.; Todd, John F. J.

doi:10.1016/j.ijms.2014.07.030

Cited by 8 publications

(7 citation statements)

References 69 publications

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“…Therefore, by varying the RF and DC voltages, different m/z will be obtained within a stable trajectory, making this type of mass analyzer very versatile, providing the ability to dynamically scan over a full mass range, while also allowing the fixing of RF and DC voltages for focusing on a selected m/z (Mathieson & Harris, ). The importance of QIT and quadrupole mass analyzers in modern analytical chemistry could form the basis of a single review; however, this is not the focus of this review, therefore interested readers are directed to the following dedicated review for more information (Dawson, ; March & Todd, ).…”

Section: Analytical Developments Driving Methodological Progressmentioning

confidence: 99%

Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism

Wilkinson

2016

Mass Spectrometry Reviews

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Over a century ago, Frederick Soddy provided the first evidence for the existence of isotopes; elements that occupy the same position in the periodic table are essentially chemically identical but differ in mass due to a different number of neutrons within the atomic nucleus. Allied to the discovery of isotopes was the development of some of the first forms of mass spectrometers, driven forward by the Nobel laureates JJ Thomson and FW Aston, enabling the accurate separation, identification, and quantification of the relative abundance of these isotopes. As a result, within a few years, the number of known isotopes both stable and radioactive had greatly increased and there are now over 300 stable or radioisotopes presently known. Unknown at the time, however, was the potential utility of these isotopes within biological disciplines, it was soon discovered that these stable isotopes, particularly those of carbon (13C), nitrogen (15N), oxygen (18O), and hydrogen (2H) could be chemically introduced into organic compounds, such as fatty acids, amino acids, and sugars, and used to “trace” the metabolic fate of these compounds within biological systems. From this important breakthrough, the age of the isotope tracer was born. Over the following 80 yrs, stable isotopes would become a vital tool in not only the biological sciences, but also areas as diverse as forensics, geology, and art. This progress has been almost exclusively driven through the development of new and innovative mass spectrometry equipment from IRMS to GC‐MS to LC‐MS, which has allowed for the accurate quantitation of isotopic abundance within samples of complex matrices. This historical review details the development of stable isotope tracers as metabolic tools, with particular reference to their use in monitoring protein metabolism, highlighting the unique array of tools that are now available for the investigation of protein metabolism in vivo at a whole body down to a single protein level. Importantly, it will detail how this development has been closely aligned to the technological development within the area of mass spectrometry. Without the dedicated development provided by these mass spectrometrists over the past century, the use of stable isotope tracers within the field of protein metabolism would not be as widely applied as it is today, this relationship will no doubt continue to flourish in the future and stable isotope tracers will maintain their importance as a tool within the biological sciences for many years to come. © 2016 The Authors. Mass Spectrometry Reviews Published by Wiley Periodicals, Inc. Mass Spec Rev

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Section: Analytical Developments Driving Methodological Progressmentioning

confidence: 99%

Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism

Wilkinson

2016

Mass Spectrometry Reviews

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“…As a result, the ion trap mass spectrometer was not the commercial success that they were expecting. Whilst this must clearly have been a set‐back at the time, with hindsight, of course, one can see that the field of mass spectrometry as a whole has benefitted hugely from the pioneering studies that Dawson and Whetten undertook in the short period of six years while Peter was at , and later by Peter Dawson on his own at Laval Université, Québec City, and at NRCC in Ottawa; these covered a wide range of issues relating to the theory, design and performance of quadrupole, monopole and ion trap mass spectrometers …”

Section: A Brief Scientific Biography Of Peter Dawsonmentioning

confidence: 99%

An appreciation of the scientific researches of Dr Peter H. Dawson

Todd

March

2019

Rapid Comm Mass Spectrometry

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Upon the death of Peter H. Dawson in 2015, mass spectrometry lost a major figure. Within the area of radiofrequency quadrupole electric fields applied to mass spectrometry, Dawson stands alongside its pioneers Wolfgang Paul, Nobelist and inventor of the technology, and Wilson Brubaker, who identified and overcame the deleterious effects of fringing electric fields on quadrupole mass filter performance. Seventy‐one of Dawson's 97 scientific publications are concerned with quadrupole mass analysers, ion traps and monopole mass spectrometers. Of especial note are his book and review articles in which he disseminated information on the theoretical fundamentals and practicalities of these systems to a wider audience, thereby having a major impact on the development of this important field of endeavour. The scientific researches of Dr Dawson, and his advice and counsel, influenced to a major degree, and to the better, the research careers, teachings and the lives of the authors of this piece. Their combined researches on quadrupole devices led to the commercialization of the ion trap as a mass spectrometer by which mass spectral information became available at greatly reduced cost. Thus, the advent of commercial ion trapping instruments permitted a greater use of mass spectrometry in both technically advanced countries and those less well advanced. The greatest impact in health services was mass spectrometric analysis of environmental problems, well and stream water, food free of pesticides, etc., and forensic sciences. Our combined indebtedness to Dr Dawson is manifested by this appreciation of his scientific work, the highlighting of his main contributions, and creation of a substantive reference source to his work that can be used by other scientists. A comprehensive list of Dr Dawson's publications, including abstracts or summaries, has been arranged in chronological order of date of submission.

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“…1% due to the assembly misalignment and fabrication precision [4]. The weight can increase to 10% or higher in some Paul trap geometrical variations [5], such as cylindrical [6] and rectilinear ion traps [7]. The nonlinear fields inevitably introduce a series of nonlinear effects into the ion motion, such as frequency shift [8][9][10], amplitude variation [11], nonlinear resonance [12][13][14][15][16], and thus have great impacts on the trap performance, in terms of mass resolution [8], mass accuracy [9], sensitivity [12], and tandem MS (MS/MS) efficiency [10,15], etc.…”

Section: Introductionmentioning

confidence: 99%

Nonlinear Ion Harmonics in the Paul Trap with Added Octopole Field: Theoretical Characterization and New Insight into Nonlinear Resonance Effect

Xiong

Zhou

Zhang

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. The nonlinear harmonics within the ion motion are the fingerprint of the nonlinear fields. They are exclusively introduced by these nonlinear fields and are responsible to some specific nonlinear effects such as nonlinear resonance effect. In this article, the ion motion in the quadrupole field with a weak superimposed octopole component, described by the nonlinear Mathieu equation (NME), was studied by using the analytical harmonic balance (HB) method. Good accuracy of the HB method, which was comparable with that of the numerical fourth-order Runge-Kutta (4th RK), was achieved in the entire first stability region, except for the points at the stability boundary (i.e., β = 1) and at the nonlinear resonance condition (i.e., β = 0.5). Using the HB method, the nonlinear 3β harmonic series introduced by the octopole component and the resultant nonlinear resonance effect were characterized. At nonlinear resonance, obvious resonant peaks were observed in the nonlinear 3β series of ion motion, but were not found in the natural harmonics. In addition, both resonant excitation and absorption peaks could be observed, simultaneously. These are two unique features of the nonlinear resonance, distinguishing it from the normal resonance. Finally, an approximation equation was given to describe the corresponding working parameter, q nr , at nonlinear resonance. This equation can help avoid the sensitivity degradation due to the operation of ion traps at the nonlinear resonance condition.

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Radio frequency quadrupole technology: Evolution and contributions to mass spectrometry

Cited by 8 publications

References 69 publications

Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism

Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism

An appreciation of the scientific researches of Dr Peter H. Dawson

Nonlinear Ion Harmonics in the Paul Trap with Added Octopole Field: Theoretical Characterization and New Insight into Nonlinear Resonance Effect

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