We present a technique to measure the amplitude of a center-of-mass (COM) motion of a twodimensional ion crystal of ∼100 ions. By sensing motion at frequencies far from the COM resonance frequency, we experimentally determine the technique's measurement imprecision. We resolve amplitudes as small as 50 pm, 40 times smaller than the COM mode zero-point fluctuations. The technique employs a spin-dependent, optical-dipole force to couple the mechanical oscillation to the electron spins of the trapped ions, enabling a measurement of one quadrature of the COM motion through a readout of the spin state. We demonstrate sensitivity limits set by spin projection noise and spin decoherence due to off-resonant light scattering. When performed on resonance with the COM mode frequency, the technique demonstrated here can enable the detection of extremely weak forces (< 1 yN) and electric fields (< 1 nV/m), providing an opportunity to probe quantum sensing limits and search for physics beyond the standard model.Measuring the amplitude of mechanical oscillators has engaged physicists for more than 50 years [1, 2] and, as the limits of amplitude sensing have dramatically improved, produced exciting advances both in fundamental physics and in applied work. Examples include the detection of gravitational waves [3], the coherent quantum control of mesoscopic objects [4], improved force microscopy [5], and the transduction of quantum signals [6]. During the past decade, optomechanical systems have facilitated increasingly sensitive techniques for reading out the amplitude of a mechanical oscillator [7][8][9][10][11], with a recent demonstration obtaining a measurement imprecision more than two orders of magnitude below z ZP T , the amplitude of the ground-state zero-point fluctuations [12]. Optomechanical systems have assumed a wide range of physical systems, including toroidal resonators, nanobeams, and membranes, but the basic principle involves coupling the amplitude of a mechanical oscillator to the resonant frequency of an optical cavity mode [4].Crystals of laser-cooled, trapped ions behave as atomic-scale mechanical oscillators [13][14][15] with tunable oscillator modes and high quality factors (∼10 6 ). Furthermore, laser cooling enables ground-state cooling and non-thermal state generation of these oscillators. Trapped-ion crystals therefore provide an ideal experimental platform for investigating the fundamental limits of amplitude sensing. Prior work has demonstrated the detection of coherently driven amplitudes larger than the zero-point fluctuations of the trapped ion oscillator [14][15][16], and reported impressive force sensing by injection locking an optically amplified oscillation of a single trapped ion [17].In this Letter we experimentally and theoretically analyze a technique to measure the center-of-mass (COM) motion of a two-dimensional, trapped-ion crystal of ∼100 ions with a sensitivity below z ZP T . We employ a timevarying spin-dependent force F 0 cos (µt) that couples the amplitude of the COM motion with...