Radio Electric Treatment Vs. Es-Citalopram In The Treatment Of Panic Disorders Associated With Major Depression: An Open-Label, Naturalistic Study

Mannu, Piero; Rinaldi, Salvatore; Fontani, Vania; Castagna, Alessandro; Margotti, Matteo Lotti

doi:10.3727/036012909803861040

Cited by 26 publications

(26 citation statements)

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“…REAC treatment has proved its efficacy in ameliorating several stress-related disorders,1,6–9 depression,5,9,10 anxiety,5,9 bipolar disorders,4 and also in some forms of dementias3 and impaired motor control 18,20. The REAC procedure is painless, and no adverse effects from its use have been reported.…”

Section: Methodsmentioning

confidence: 99%

“…Radioelectric asymmetric brain stimulation technology with its treatment protocols has shown efficacy in various psychiatric disorders 1–10. The aim of this work was to highlight the mechanisms by which these positive effects are achieved.…”

Section: Introductionmentioning

confidence: 99%

“…Images are usually separated by 1–4 seconds, and the stimuli or the cognitive and motor tasks are carried out during the fMRI session. It has previously been observed that the changes in psychological1,3–10 and motor behavior activity18–20 resulting from radioelectric asymmetric conveyor (REAC) brain stimulation pulse (BSP) stimulation are relatively long lasting, the persistence of effects has been observed for a few years. Although the duration of the REAC stimulus is brief (500 milliseconds), it was hypothesized that changes in brain activity following stimulation would be observable using fMRI, despite the low temporal resolution of this imaging modality.…”

Section: Introductionmentioning

confidence: 99%

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Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study

Rinaldi¹,

Fontani²,

Castagna³

2011

NDT

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PurposeRadioelectric asymmetric brain stimulation technology with its treatment protocols has shown efficacy in various psychiatric disorders. The aim of this work was to highlight the mechanisms by which these positive effects are achieved. The current study was conducted to determine whether a single 500-millisecond radioelectric asymmetric conveyor (REAC) brain stimulation pulse (BSP), applied to the ear, can effect a modification of brain activity that is detectable using functional magnetic resonance imaging (fMRI).MethodsTen healthy volunteers, six females and four males, underwent fMRI during a simple finger-tapping motor task before and after receiving a single 500-millisecond REAC-BSP.ResultsThe fMRI results indicate that the average variation in task-induced encephalic activation patterns is lower in subjects following the single REAC pulse.ConclusionThe current report demonstrates that a single REAC-BSP is sufficient to modulate brain activity in awake subjects, able to be measured using fMRI. These initial results open new perspectives into the understanding of the effects of weak and brief radio pulses upon brain activity, and provide the basis for further indepth studies using REAC-BSP and fMRI.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study

Rinaldi¹,

Fontani²,

Castagna³

2011

NDT

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“…Biological therapies: In open-label case series, noninvasive brain stimulation using a radioelectric asymmetric conveyor (REAC) demonstrated efficacy for panic symptoms and agoraphobia (Level 3) [297,298]. A small case series suggested repetitive transcranial magnetic stimulation (rTMS) could improve panic and anxiety in patients with panic disorder with comorbid MDD (Level 4) [299].…”

Section: Panic Disorder and Agoraphobiamentioning

confidence: 99%

Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders

et al. 2014

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BackgroundAnxiety and related disorders are among the most common mental disorders, with lifetime prevalence reportedly as high as 31%. Unfortunately, anxiety disorders are under-diagnosed and under-treated.MethodsThese guidelines were developed by Canadian experts in anxiety and related disorders through a consensus process. Data on the epidemiology, diagnosis, and treatment (psychological and pharmacological) were obtained through MEDLINE, PsycINFO, and manual searches (1980–2012). Treatment strategies were rated on strength of evidence, and a clinical recommendation for each intervention was made, based on global impression of efficacy, effectiveness, and side effects, using a modified version of the periodic health examination guidelines.ResultsThese guidelines are presented in 10 sections, including an introduction, principles of diagnosis and management, six sections (Sections 3 through 8) on the specific anxiety-related disorders (panic disorder, agoraphobia, specific phobia, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, and posttraumatic stress disorder), and two additional sections on special populations (children/adolescents, pregnant/lactating women, and the elderly) and clinical issues in patients with comorbid conditions.ConclusionsAnxiety and related disorders are very common in clinical practice, and frequently comorbid with other psychiatric and medical conditions. Optimal management requires a good understanding of the efficacy and side effect profiles of pharmacological and psychological treatments.

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“…Therefore, on the basis of clinical observation and the reductions in total AS scores, the response to REAC-NPPO therapy appears to be very favorable. It is interesting to note that, compared with previous studies published on bipolar disorder,29 panic disorder,27 generalized anxiety disorder,25,26,28 Alzheimer’s disease,30 and various stress-related disorders,22–26 the response of agoraphobia to REAC-NPPO therapy was slower and less robust, as significant improvement on anxiety and avoidance was not present at the first timepoint (t1). One possible explanation for this could be that agoraphobia may be a secondary complication of the primary disorder (ie, panic disorder) and would therefore be less affected by treatment, similar to the effects of treatment on alcohol dependence in an individual with social anxiety disorder.…”

Section: Discussionmentioning

confidence: 77%

Noninvasive brain stimulation by radioelectric asymmetric conveyor in the treatment of agoraphobia: open-label, naturalistic study

Mannu

Rinaldi²,

Fontani³

et al. 2011

PPA

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BackgroundAgoraphobia is considered to be the most serious complication of panic disorder. It involves progressive development of debilitating anxiety symptoms related to being in situations where one would be extremely embarrassed and could not be rescued in the case of a panic attack. This study aimed to investigate the efficacy of noninvasive brain stimulation using a radioelectric asymmetric conveyor (REAC) for agoraphobia.Patients and methodsTwenty-three patients (3 males and 20 females) suffering from agoraphobia and without a history of panic disorder were evaluated by a psychiatrist using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, and the Agoraphobia Scale (AS). The patients were subjected to two 18-session cycles of noninvasive brain stimulation with the REAC, according to an established therapeutic protocol called neuropsycho-physical optimization.ResultsAnalyzing the anxiety and avoidance parameters of the AS after the first and second cycles of REAC treatment revealed variation in levels of response to treatment, including weak (AS item 7), moderate (AS items 10 and 13), and good responses (AS items 1–6, 8, 9, 11, 12, and 14–20).ConclusionThese results highlight the potential of the REAC to treat complex clinical situations such as agoraphobia, which is typically resistant to pharmacologic treatments. Furthermore, these data show the advantages of REAC treatment, even compared with modern cognitive behavioral therapy, including a relatively rapid and “stable” clinical response (just over 6 months) and economic cost.

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Radio Electric Treatment Vs. Es-Citalopram In The Treatment Of Panic Disorders Associated With Major Depression: An Open-Label, Naturalistic Study

Cited by 26 publications

References 0 publications

Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study

Brain activity modification produced by a single radioelectric asymmetric brain stimulation pulse: a new tool for neuropsychiatric treatments. Preliminary fMRI study

Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders

Noninvasive brain stimulation by radioelectric asymmetric conveyor in the treatment of agoraphobia: open-label, naturalistic study

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