Abstract:In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-infla… Show more
“…REAC for therapeutic use is a technology platform for biomodulation 28 , 43 – 61 and neuromodulation, 7 , 8 , 10 , 11 , 13 – 27 , 62 which has been shown to be effective even in neurodegenerative diseases. 57 , 60 The scientific background of the REAC technology platform is based on a fundamental phenomenon for life: the cell polarity. Cell polarity is the asymmetric organization of several cellular components, including the plasma membrane, cytoskeleton, and organelles.…”
PurposeThe purpose of this preliminary observational study was to evaluate the usefulness of a humanitarian initiative, aimed at improving the neuropsychological and behavioral attitude of children with severe socioeconomic and cultural hardship, in the Brazilian state of Pará. This humanitarian initiative was realized through the administration of two neuromodulation protocols, with radioelectric asymmetric conveyor (REAC) technology. During several years of clinical use, the REAC neuromodulation protocols have already proved to be effective in countering the effects of environmental stress on neuropsycho-physical functions.Patients and methodsAfter the preliminary medical examination, all subjects were investigated with the Strengths and Difficulties Questionnaire (SDQ), including the impact supplement with teacher’s report. After the SDQ, they received the neuromodulation treatment with REAC technology named neuro postural optimization (NPO), to evaluate their responsiveness. Subsequently, every 3 months all subjects underwent a treatment cycle of neuropsycho-physical optimization (NPPO) with REAC technology, for a total of three cycles. At the end of the last REAC-NPPO treatment cycle, all subjects were investigated once again with the SDQ. For the adequacy of the data, the Wilcoxon and the Signs tests were used. For the subdivision into clusters, the Kruskal–Wallis test was applied for the adequacy of the procedure. For all the applied tests, a statistical significance of p<0.5 was found.ResultsThe results showed that the REAC-NPO and REAC-NPPO neuromodulation protocols are able to improve the quality of life, the scholastic and socialization skills, and the overall state of physical and mental health in children of a family with severe socioeconomic and cultural hardship.ConclusionThe REAC-NPO and REAC-NPPO neuromodulation protocols, due to their non-invasive characteristics, painlessness, and speed of administration, can be hypothesized as a treatment to improve the overall state of physical and mental health in a large number of people with socioeconomic and cultural discomfort.
“…REAC for therapeutic use is a technology platform for biomodulation 28 , 43 – 61 and neuromodulation, 7 , 8 , 10 , 11 , 13 – 27 , 62 which has been shown to be effective even in neurodegenerative diseases. 57 , 60 The scientific background of the REAC technology platform is based on a fundamental phenomenon for life: the cell polarity. Cell polarity is the asymmetric organization of several cellular components, including the plasma membrane, cytoskeleton, and organelles.…”
PurposeThe purpose of this preliminary observational study was to evaluate the usefulness of a humanitarian initiative, aimed at improving the neuropsychological and behavioral attitude of children with severe socioeconomic and cultural hardship, in the Brazilian state of Pará. This humanitarian initiative was realized through the administration of two neuromodulation protocols, with radioelectric asymmetric conveyor (REAC) technology. During several years of clinical use, the REAC neuromodulation protocols have already proved to be effective in countering the effects of environmental stress on neuropsycho-physical functions.Patients and methodsAfter the preliminary medical examination, all subjects were investigated with the Strengths and Difficulties Questionnaire (SDQ), including the impact supplement with teacher’s report. After the SDQ, they received the neuromodulation treatment with REAC technology named neuro postural optimization (NPO), to evaluate their responsiveness. Subsequently, every 3 months all subjects underwent a treatment cycle of neuropsycho-physical optimization (NPPO) with REAC technology, for a total of three cycles. At the end of the last REAC-NPPO treatment cycle, all subjects were investigated once again with the SDQ. For the adequacy of the data, the Wilcoxon and the Signs tests were used. For the subdivision into clusters, the Kruskal–Wallis test was applied for the adequacy of the procedure. For all the applied tests, a statistical significance of p<0.5 was found.ResultsThe results showed that the REAC-NPO and REAC-NPPO neuromodulation protocols are able to improve the quality of life, the scholastic and socialization skills, and the overall state of physical and mental health in children of a family with severe socioeconomic and cultural hardship.ConclusionThe REAC-NPO and REAC-NPPO neuromodulation protocols, due to their non-invasive characteristics, painlessness, and speed of administration, can be hypothesized as a treatment to improve the overall state of physical and mental health in a large number of people with socioeconomic and cultural discomfort.
“…24 – 26 These effects have also been demonstrated with basic research at the molecular level 27 – 29 and on the animal model. 30 – 33 Figure 1 The image shows the example of a patient suffering from non-specific neck pain during the administration of the tissue optimization treatment. ( A ) device based on REAC technology, model BENE 101 (ASMED, Florence, Italy); ( B ) asymmetric conveyer probe (ACP).…”
Section: Methodsmentioning
confidence: 99%
“…[24][25][26] These effects have also been demonstrated with basic research at the molecular level [27][28][29] and on the animal model. [30][31][32][33]…”
Introduction: Non-specific neck pain (NSNP) is a rather common symptomatology, and various therapeutic approaches are aimed to treat it, in the field of manual therapy, physiotherapy and pharmacology. Methods: This retrospective study analyzes 65 subjects treated for NSNP with a neurobiological stimulation administered by medical devices based on radio electric asymmetric conveyer (REAC) technology. Initially, a neuro stimulation treatment called neuro postural optimization (NPO) was administered to improve the coordination of muscle activity and reduce adaptive decompensations. Subsequently, the bio stimulation treatment called tissue optimization (TO) was administered to reduce the algodystrophic and muscle contracture component. The evaluation of the efficacy of these treatments was made through the subjective evaluation of pain by the patients. Data were collected by the use of the numeric pain rating scale (NPRS) and neck pain questionnaire (NPQ), administered before the treatments and at the end of the cycle of therapy. Results: The analysis of the results shows that this type of approach and treatment scheme is effective in reducing the symptoms of NSNP in both male and female subjects, regardless of their age. Other subjective data not quantified in this study but reported by all subjects, during and after the treatment cycle, were a feeling of lower stiffness of neck and shoulder, a reduction in the thickening of the cervicobrachial tissues, and a clear and progressive reduction of pain perception during the skin rolling (SR) maneuver. Conclusion: The combination of REAC-NPO neuromodulation and REAC-TO biomodulation treatments used in this study was shown to be effective in NPRS.
“…Contribution of mitochondrial dysfunction to pathogenic α-syn aggregation has been reported in the studies on the role of some environmental toxins in PD pathology. A well-known neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been widely used as a tool drug for modeling PD symptoms in animal studies (Ghosh et al, 2016;Gu et al, 2017;Panaro et al, 2018;Ren et al, 2018;Wang et al, 2015). MPTP, itself is not toxic, but is lipid-soluble and easy to cross the bloodbrain barrier into central nervous system (CNS).…”
The presence of intraneuronal Lewy bodies (LBs) and Lewy neurites (LNs) in the substantia nigra (SN) composed of aggregated α-synuclein (α-syn) has been recognized as a hallmark of pathological changes in Parkinson's disease (PD). Numerous studies have shown that aggregated α-syn is necessary for neurotoxicity. Meanwhile, the mitochondrial and lysosomal dysfunctions are associated with α-syn pathogenicity. The hypothesis that α-syn transmission in the human brain contributes to the instigation and progression of PD has provided insights into PD pathology. This review will provide a brief overview of increasing researches that shed light on the relationship of α-syn aggregation with mitochondrial and lysosomal dysfunctions, and highlight recent understanding of α-syn transmission in PD pathology.
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