Radical α–alkylation of ketones with unactivated alkenes under catalytic and sustainable industrial conditions

Solid-catalyzed synthesis of isomers–free terpinen–4–ol

“…The supported transition metal oxides were prepared by standard procedures [29][30][31][32][33][34][35], which consists in brief in: (1) impregnation of the metal oxide with an aqueous solution of the corresponding transition metal salt at either 0.5 or 1 wt% amount, (2) dry at 100 • C in an oven, and (3) calcination and reduction. Details can be found in the Supporting Information.…”

Single Atom and Metal Cluster Catalysts in Organic Reactions: From the Solvent to the Solid

“…-loaded zeolites was employed to trigger the radical reaction. [18] This strategy, beyond supporting the metal, has the advantage of not requiring acetic acid as a solvent. Y and Beta zeolites exchanged with Mn 2 + , including also Na + and NH 4 + countercations, worked well as catalysts for the coupling of allyl acetate and cyclododecanone, to achieve the desired alkylated product (Figure 3).…”

Synthesis of Dehydromuscone by an Alkene Metathesis Macrocyclization Reaction at 0.2 M Concentration

“…with Pd/C as a catalyst, gives 2 in quantitative yield (99%), 18 and the final transformation of 2 to 1 proceeds as reported 2 to give 1 after five linear steps in 19% overall yield (compare with the current route that employs at least seven linear steps with <20% yields). 1,2 The present synthetic route circumvents CCDK as a starting material, 19 uses readily available linear compounds 20 and employs realistic reaction conditions for scaling up. In particular, the use of a RCM macrocyclization reaction at >0.1 M concentration with the relatively inexpensive Grela´s type catalyst offer an opportunity for the synthesis of 1 at the industrial level.…”

“…The present synthetic route circumvents the need for CCDK as a starting material, 19 uses readily available linear compounds, 20 and employs reaction conditions that could be realistically scaled up. In particular, the use of an RCM macrocyclization reaction at a >0.1 M concentration with the relatively inexpensive Grela-type catalysts provides an opportunity for the synthesis of 1 at an industrial level.…”