Radical vulvectomy and groin node dissection in a patient with chronic neutropenia—maintenance of leucocyte count using granulocyte colony-stimulating factor

Abstract

A patient was referred for consideration of radical surgery in the presence of chronic neutropenia. We report the successful maintenance of an adequate neutrophil count during the perioperative period using Granulocyte colony-stimulating factor (GCSF), resulting in successful primary healing of the wounds in the absence of infective complications. The use of GCSF in gynecology is briefly reviewed.

Sporadic case of warts, hypogammaglobulinemia, immunodeficiency, and myelokathexis syndrome

“…Despite severe neutropenia, patients with WHIMS do not appear to be at risk of overwhelming neutropenic sepsis, presumably because functional neutrophils are released from the bone marrow during stress; indeed, granulocyte colony stimulating factor (G-CSF) has been demonstrated to correct neutropenia and normalize the bone marrow in WHIMS. [9][10][11][12] The frequency and extent of lymphoid abnormalities appears to be very variable, with reports of B and T cytopenias as well as poor T-cell function. However, despite lymphopenia in a large proportion of patients, there are no reports of opportunistic or mycobacterial infections, and childhood infections such as rubella run a benign course.…”