“…Despite severe neutropenia, patients with WHIMS do not appear to be at risk of overwhelming neutropenic sepsis, presumably because functional neutrophils are released from the bone marrow during stress; indeed, granulocyte colony stimulating factor (G-CSF) has been demonstrated to correct neutropenia and normalize the bone marrow in WHIMS. [9][10][11][12] The frequency and extent of lymphoid abnormalities appears to be very variable, with reports of B and T cytopenias as well as poor T-cell function. However, despite lymphopenia in a large proportion of patients, there are no reports of opportunistic or mycobacterial infections, and childhood infections such as rubella run a benign course.…”