Radical surgery for gastric cancer. A review of the Japanese experience

Noguchi, Yoshikazu; Imada, Toshio; Matsumoto, Akihiko; Coit, Daniel G.; Brennan, Murray F.

doi:10.1002/1097-0142(19891115)64:10<2053::aid-cncr2820641014>3.0.co;2-j

Cited by 305 publications

(106 citation statements)

References 20 publications

(1 reference statement)

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“…This is probably owing to a more advanced stage of the tumours in the former site, frequently in pT3 or pT4 at the diagnosis (Hermanek, 1986;Davessar et al, 1990). Furthermore, the extensive distribution of potentially metastatic lymph nodes in advanced cancer of the proximal third may explain the poorer prognosis (Noguchi et al, 1989). In our study, survival rates of the tumours in the middle or distal parts were almost twice as favourable as those in the proximal third (5 year survival 30-35% vs 15% respectively).…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration

Setälä

Kosma²,

Marin³

et al. 1996

Br J Cancer

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Summary A retrospective analysis of 321 gastric cancer patients was made to assess the prognostic value of TNM classification, tumour differentiation, Lauren classification, proliferative rate, inflammatory reaction and tumour invasion in vascular or neural structures of the gastric wall. The TNM classification showed the strongest correlation with survival in univariate and multivariate analyses (P<0.0001). The invasion in lymphatic or vascular system and Lauren classification were also independent prognosticators in multivariate analysis (P<0.05). In univariate analysis, the WHO-grade, the size and the location of the tumour and perinueral invasion were significant prognostic factors (P<0.01), as were the infiltration of lymphocytes and plasma cells in the tumour (P<0.05). On the other hand, the mitotic indices reflecting the proliferative activity of the tumour cells showed no significant correlation with the prognosis. The results indicate that the prognostic power of the TNM classification can be further increased by assessment of the above special histological features in gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration

Setälä

Kosma²,

Marin³

et al. 1996

Br J Cancer

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“…Previous cohort studies have highlighted the survival difference in patients with resectable GC between Western and Eastern countries [6][7][8][9][10][11][12][13][14]. Noguchi et al [6] reported a survival difference between high-volume centers in the USA and Japan that was no longer apparent after adjusting for tumor location.…”

Section: Introductionmentioning

confidence: 99%

The survival difference between gastric cancer patients from the UK and Japan remains after weighted propensity score analysis considering all background factors

et al. 2015

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Background Previous studies comparing survival between gastric cancer (GC) patients from the West and the East were based on the assumption that background factors and prognostic factors were identical. The aim of the current study was to compare the survival of GC patients from the UK and Japan using weighted propensity score analysis after identifying all different background factors. Methods Data from 464 patients from the Leeds Teaching Hospital NHS Trust, Leeds, UK (LTHT), and 465 patients from the Kanagawa Cancer Center Hospital, Yokohama, Japan (KCCH), who had surgery for GC were analyzed. Prognostic factors for overall survival (OS) and cancer-specific survival (CSS) were identified by univariate and multivariate analyses. Survival was compared by propensity score weighting after adjusting for all significantly different background factors. Results Most background factors were different between LTHT and KCCH patients. Unadjusted stage-specific OS and CSS were significantly better in KCCH. Independent prognostic factors for unadjusted OS and CSS were pT and pN in KCCH and in addition tumor location, pancreatectomy, resection margin status and number of examined lymph nodes in LTHT. Even after adjusting for all background characteristics, survival remained better in KCCH. Conclusions These results suggest that differences in background factors are unable to fully explain the survival difference of GC patients between UK and Japan. Comprehensive studies into the biology of GC and/or host factors are needed to fully understand the survival difference.

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confidence: 99%

“…Curative surgery is an essential treatment for the long-term survival of patients with gastric cancer (Noguchi et al, 1989;Shiu et al, 1989;Fuchs and Mayer, 1995). However, the prognosis of patients with locally advanced gastric cancer is generally poor even with curative resection (Noguchi et al, 1989;Shiu et al, 1989;Fuchs and Mayer, 1995). Adjuvant chemotherapy has failed to demonstrate a significant survival benefit for such patients in most randomized trials and meta-analyses, except in a few studies with positive results (Shiu et al, 1989;Krook et al, 1991;Kim et al, 1992;Hermans et al, 1993;Nakazato et al, 1994;Fuchs and Mayer, 1995;Lise et al, 1995;Macdonald et al, 1995;Kelsen, 1996;Kim et al, 1998;Cirera et al, 1999;Earle and Maroun, 1999).…”

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Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection

Lim

Nam

et al. 2001

Br J Cancer

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SummaryWe evaluated the expression of thymidylate synthase (TS) in locally advanced gastric cancer patients treated with adjuvant chemotherapy after curative resection and investigated the association between TS expression and clinicopathologic characteristics including prognosis of the patients. TS expression was evaluated by immunohistochemical staining using TS106 monoclonal antibody in 103 locally advanced gastric cancer patients (stage IB-IV) who underwent 5-fluorouracil (5-FU) and doxorubicin-based adjuvant chemotherapy after curative resection. 65 patients (63%) had primary tumours with high TS expression (≥ 25% of tumour cells positive), and 38 patients (37%) demonstrated low TS expression (< 25% of tumour cells positive or no staining). High TS expression was associated with male gender (P = 0.002), poorly differentiated histology (P = 0.015), and mixed type in Lauren's classification (P = 0.027). There were no statistically significant differences in 4-year disease-free survival (60.0% vs 57.2%, P = 0.548) and overall survival (59.6% vs 59.3%, P = 0.792) between high-TS group and low-TS group. In conclusion, although high TS expression was associated with poorly differentiated histology and mixed type in Lauren's classification, it did not predict poor disease-free and overall survival in gastric cancer patients treated with 5-FU and doxorubicin-based adjuvant chemotherapy after curative resection. Further prospective studies including the evaluation of other biological markers associated with the resistance to 5-FU and doxorubicin are necessary. 186-192 © 2001 Cancer Research Campaign doi: 10.1054/ bjoc.2000.1553, available online at http://www.idealibrary.com on http://www.bjcancer.com based adjuvant chemotherapy after curative surgical resection at Ajou University Medical Center in Suwon, Korea, between July 1994 and October 1996. All patients had a postsurgical pathologic stage ranging from IB to IV without evidence of distant metastasis according to the American Joint Committee on Cancer TNM classification (American Joint Committee on Cancer, 1997). Curative resection was defined by the General Rules for the Gastric Cancer Study in Surgery and Pathology of the Japanese Research Society for Gastric Cancer as: no involvement of surgical stumps; sufficient lymphatic dissection (R number ≥ N number); no distant metastasis; removal of involved adjacent organs and structures by combined en-bloc resection; and no gross residual disease (Japanese Research Society for Gastric Cancer, 1981). None of these patients received chemotherapy prior to surgery.Although all patients received 5-FU and doxorubicin-based adjuvant chemotherapy, the regimens were not uniform. The most commonly administered regimen was FA (5-FU, doxorubicin) with OK-432 (51 patients), followed by FAM (5-FU, doxorubicin, mitomycin-C) (33 patients), FA (11 patients), and FA with lentinan (eight patients). Chemotherapy was usually started 2-3 weeks after surgery. In the FA regimen with or without immunotherapy (OK-432 or lentinan), 5-FU (...

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Radical surgery for gastric cancer. A review of the Japanese experience

Cited by 305 publications

References 20 publications

Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration

Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration

The survival difference between gastric cancer patients from the UK and Japan remains after weighted propensity score analysis considering all background factors

Expression of thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection

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