Radical serotype rearrangement of carried pneumococci in the first 3 years after intensive vaccination started in Hungary

Tóthpál, Adrienn; Kardos, Szilvia; Laub, Krisztina; Nagy, K.; Tirczka, Tamás; Linden, Mark van der; Dobay, Orsolya

doi:10.1007/s00431-014-2408-1

Cited by 15 publications

(10 citation statements)

References 31 publications

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“…These latter data are available online, in Hungarian, reported annually by the National Bacteriological Surveillance Management Team of the National Public Health Center [72]. In case of S. aureus and S. pneumoniae, this difference has been observed also in our previous studies [18,39,40,73].…”

Section: Serotypesupporting

confidence: 69%

Co-carriage of Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among three different age categories of children in Hungary

et al. 2020

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BackgroundThe nasopharynx can from time to time accommodate otherwise pathogenic bacteria. This phenomenon is called asymptomatic carriage. However, in case of decreased immunity, viral infection or any other enhancing factors, severe disease can develop. Our aim in this study was to survey the nasal carriage rates of four important respiratory pathogens in three different age groups of children attending nurseries, day-care centres and primary schools. This is the first study from Hungary about the asymptomatic carriage of H. influenzae and M. catarrhalis. MethodsAltogether 580 asymptomatic children were screened in three Hungarian cities. Samples were collected from both nostrils with cotton swabs. The identification was based on both colony morphology and species-specific PCRs. Serotyping was performed for S. pneumoniae, H. influenzae and M. catarrhalis. Antibiotic susceptibility was determined with agar dilution, according to the EUCAST guidelines. Clonality was examined by PFGE. Results and conclusionsWhereas the carriage rates of S. pneumoniae, H. influenzae and M. catarrhalis clearly decreased with age, that of S. aureus showed an opposite tendency. Multiple carriage was least prevalent if S. aureus was one of the participants. The negative association between this bacterium and the others was statistically significant. For pneumococcus, the overall carriage rate was lower compared to earlier years, and PCV13 serotypes were present in only 6.2% of the children. The majority of H. influenzae isolates was non-typeable and no PLOS ONE | https://doi.

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Section: Serotypesupporting

confidence: 69%

Co-carriage of Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among three different age categories of children in Hungary

et al. 2020

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“…Also in Japan, as demonstrated in the present study, serotype 19A emerged as a dominant serotype after PCV7 introduction, showing the highest rate of isolates with both erm (B) and mef (A/E) among all the serotypes. Similarly, a high prevalence of these macrolide resistance genes in serotype 19A pneumococci was described in the United States, Europe and Asia (Taiwan) [27] , [28] , [29] , [30] , furthermore, macrolide-resistant pneumococci carrying both resistance genes were associated with multidrug resistance [31] , [32] . Thus, it is possible that such drug resistance traits of serotype 19A may be one of the reasons for persistence of this serotype even after introduction of PCV13.…”

Section: Discussionmentioning

confidence: 73%

Emerging non-PCV13 serotypes of noninvasive Streptococcus pneumoniae with macrolide resistance genes in northern Japan

Kawaguchiya

Urushibara

Aung

et al. 2016

New Microbes and New Infections

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In Japan, the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced to the nation's routine immunization program in April 2013 and was replaced by the 13-valent pneumococcal conjugate vaccine (PCV13) in November 2013. Distribution of serotypes and macrolide resistance genotypes was investigated for a total of 1097 (975 children, 122 adults) and 960 (873 children, 87 adults) clinical isolates of Streptococcus pneumoniae from noninvasive infections in Hokkaido (northern main island of Japan) in the routine immunization periods for PCV7 and PCV13 (April–October 2013 and November 2013–November 2014, respectively). Serotype was determined by sequential multiplex PCR and additional genetic analyses. Macrolide resistance genes erm(B) and mef(A/E) were detected by multiplex PCR. Although the most prevalent serotypes in children were 23A and 6C in the PCV7 period, after replacement with PCV13, 19A became the most common, followed by 6C, 15A and 23A. Among adults, serotype 3 was consistently the most frequent throughout the study periods. Compared with values from the pre-PCV7 routine immunization period, PCV7 serotypes decreased from 48.3 to 3.3% in the PCV13 period among children, while the rates of non-PCV13 serotypes (particularly 15A, 23A, 11A, 10A and 35B) increased from 39.7 to 75.1% (p < 0.001). In the PCV13 period, erm(B), mef(A/E) and both of these genes were detected in 75.8, 31.6 and 11.3% of all isolates, respectively. Serotype 19A accounted for 76.9% of the isolates with both the macrolide resistance genes, and emerging non-PCV13 serotypes 15A, 15C and 23A mostly harboured erm(B).

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“…Several surveys have documented the effect of PCV on NP carriage with conflicting results ( 10 , 11 , 12 ). The main reason for the unchanged prevalence of NP carriage is serotype replacement of non-vaccine types ( 13 , 14 ). After the introduction of PCV7, the incidence of pneumococcal disease and NP carriage due to NVTs, most notably for serotype 19A, increased incrementally.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, NP carriage prevalence was found to be higher in children attending a day-care centre. In a study carried out in Hungary, the NP carriage rate among unvaccinated children attending a day-care centre was also found to be higher ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

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Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey

et al. 2017

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Aims: To determine the prevalence of nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged 0-6 years who were vaccinated with pneumococcal conjugate vaccine.Methods: This cross-sectional study was conducted on 150 healthy Turkish children between 1 month and 6 years of age. Serotyping was performed and risk factors of carriage were evaluated.Results: The overall carriage rate was 14%. Vaccine type serotypes were determined in 17 (12.6%) children who received full-dose PCV13 vaccine. The highest carriage rate was observed among children younger than 24 months (76.2%). In multivariate analysis, respiratory infection in recent months, age, attendance at a day-care center and antibiotic usage were not statistically significant risk factors for carriage. Overall, S. pneumoniae strains were considered as penicillin susceptible and antimicrobial resistance was limited.Conclusion: We observed a low rate of pneumococcal carriage in children after PCV13 implementation compared with that of children receiving PCV7. Although it was reduced, vaccine serotype colonization in PCV13-vaccinated children remains persistent.

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Radical serotype rearrangement of carried pneumococci in the first 3 years after intensive vaccination started in Hungary

Abstract: Due to PCV vaccination, a complete serotype arrangement occurred also in Hungary. The old "paediatric" serotypes were replaced by serotypes 11A, 35F, 19A, 6B, 15B, 3 and 38.

Cited by 15 publications

References 31 publications

Co-carriage of Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among three different age categories of children in Hungary

Co-carriage of Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis among three different age categories of children in Hungary

Emerging non-PCV13 serotypes of noninvasive Streptococcus pneumoniae with macrolide resistance genes in northern Japan

Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey

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