Radical-scavenging-linked antioxidant activities of extracts from black chokeberry and blueberry cultivated in Korea

Hwang, Seok Joon; Yoon, Won Byong; Lee, Ok‐Hwan; Ju, Seung; Kim, Jong Dai

doi:10.1016/j.foodchem.2013.09.035

Cited by 103 publications

(73 citation statements)

References 56 publications

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“…The highest levels of activities evaluated by the FRAP assay were observed in ethanol extract of stem bark (36060.9 μmol TE/100 g). These results are in agreement with that of a previous report by Korekar et al (2011) Hwang et al (2014) in which high correlation coefficients were found between the in vitro antioxidant activities and antioxidant compounds of extracts from cultivated black chokeberry and blueberry.…”

Section: Antioxidant Activitiessupporting

confidence: 93%

Potential nutritional and antioxidant activity of various solvent extracts from leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used in folk medicine

Onivogui

Zhang

Diaby

et al. 2017

Braz. J. Pharm. Sci.

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Section: Antioxidant Activitiessupporting

confidence: 93%

Potential nutritional and antioxidant activity of various solvent extracts from leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used in folk medicine

Onivogui

Zhang

Diaby

et al. 2017

Braz. J. Pharm. Sci.

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“…Blueberry and blueberry juice not only contain main dietary nutrients including minerals, sugars, and vitamins, but also are regarded as one of the most abundant and accessible sources of the bioactive components that are beneficial to the human health (Hwang et al, 2014;Seeram, 2008). There are some researches display that dietary intake of blueberry and its derived products can protect our body from various diseases including cancer, ageing, urinary disease, heart disease, memory loss, and vision problems (Pertuzatti et al, 2014;Shi et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Sonication enhances quality and antioxidant activity of blueberry juice

Zou

Hou

2017

Food Sci. Technol

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Effect of sonication on the blueberry juice was studied by evaluating the pH, viscosity, electric conductivity, color, total sugars, soluble solids, polyphenol, anthocyanidin, and radical scavenging activities. There were not any remarkable (p > 0.05) change in pH and electric conductivity. However, viscosity and color of blueberry juice markedly (p < 0.05) enhanced with the extension of sonication time. Meanwhile, total sugars, soluble solids, polyphenol, and anthocyanidin were obviously enhanced (p < 0.05). Moreover, prominent increase (p < 0.05) was observed on DPPH, superoxide, and hydroxyl radicals scavenging activities of sonicated blueberry juice. The current results exhibited sonication effectively improved blueberry juice quality and enhanced its antioxidant activity.

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“…Procyanidin B1 is the major procyanidin found in most commonly eaten fruits and fruit juices [2,[25][26][27] and produces anti-inflammatory effects in human monocytes [1,9,10]. The data presented here indicate that procyanidin B1 may mediate these effects by acting as a competitive antagonist against TLR4/MD-2 activation of MAPK and NF-jB signaling and production of TNF-a.…”

Section: Discussionmentioning

confidence: 66%

“…Procyanidins are polyphenolic flavonoids that are abundant in commonly eaten fruits and fruit juices, for which procyanidins B1, B2, C1, and C2 possess a wide range of physiologic activities [1][2][3][4]. The consumption of these and other bioactive food compounds has been suggested to have beneficial effects on inflammation-related diseases [5,6].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of procyanidin B1 on LPS-treated THP1 cells via interaction with the TLR4–MD-2 heterodimer and p38 MAPK and NF-κB signaling

Xing

et al. 2015

Mol Cell Biochem

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Anti-inflammatory effects of procyanidin B1 have been documented; however, the molecular mechanisms that are involved have not been fully elucidated. Molecular docking models were applied to evaluate the binding capacity of lipopolysaccharide (LPS) and procyanidin B1 with the toll-like receptor (TLR)4/myeloid differentiation factor (MD)-2 complex. LPS-induced production of the proinflammatory cytokine tumor necrosis factor (TNF)-α in a human monocyte cell line (THP1) was measured by ELISA. mRNA expression of MD-2, TLR4, TNF receptor-associated factor (TRAF)-6, and nuclear factor (NF)-κB was measured by real-time PCR with or without an 18-h co-treatment with procyanidin B1. In addition, protein expression of phosphorylated p38 mitogen-activated protein kinase (MAPK) and NF-κB was determined by Western blotting. Structural modeling studies identified Tyr296 in TLR4 and Ser120 in MD-2 as critical sites for hydrogen bonding with procyanidin B1, similar to the sites occupied by LPS. The production of TNF-α was significantly decreased by procyanidin B1 in LPS-treated THP1 cells (p < 0.05). Procyanidin B1 also significantly suppressed levels of phosphorylated p38 MAPK and NF-κB protein, as well as mRNA levels of MD-2, TRAF-6, and NF-κB (all p < 0.05). Procyanidin B1 can compete with LPS for binding to the TLR4-MD-2 heterodimer and suppress downstream activation of p38 MAPK and NF-κB signaling pathways.

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Radical-scavenging-linked antioxidant activities of extracts from black chokeberry and blueberry cultivated in Korea

Cited by 103 publications

References 56 publications

Potential nutritional and antioxidant activity of various solvent extracts from leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used in folk medicine

Potential nutritional and antioxidant activity of various solvent extracts from leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used in folk medicine

Sonication enhances quality and antioxidant activity of blueberry juice

Anti-inflammatory effect of procyanidin B1 on LPS-treated THP1 cells via interaction with the TLR4–MD-2 heterodimer and p38 MAPK and NF-κB signaling

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