Radical Scavenging Effect of Naturally-occurring Epigallocatechin Gallate Against Oxidative Damage Caused by Gamma-ray Radiation

Abstract

Exposure to ionizing radiation results in the generation of reactive oxygen species that induce damage in the form of mutations.epigallcatechin gallate is considered to be a radioprotective agent. The radical scavenging effect of on γ rays irradiated plasmid was evaluated. The num-

Radiation Protection of Yeast Cells and DNA by Epigallocatechin Gallate and Epicatechin

“…6) One of the mechanisms that explains the protective 2008) reported that the lowest unoccupied molecular orbital level of EGCG is higher than that of EC, indicating that the reducing power of EGCG is stronger than that of EC. 13) The radical scavenging effect of EGCG on DNA thus arises from its dual activities of reactive intermediate scavenging and reducing power in the Fenton reaction. 12,13) At low concentrations, EGCG protects DNA against oxidative damage, and with increasing concentrations, EGCG reduces iron ions that accelerate the generation of •OH from the Fenton reaction.…”

“…13) The radical scavenging effect of EGCG on DNA thus arises from its dual activities of reactive intermediate scavenging and reducing power in the Fenton reaction. 12,13) At low concentrations, EGCG protects DNA against oxidative damage, and with increasing concentrations, EGCG reduces iron ions that accelerate the generation of •OH from the Fenton reaction.…”

“…However, it has been reported that DSB is generated in the cell nucleus by irradiation with 100 Gy. 13) The major cause of cell death is not SSB but DSB. Therefore, the decrease in survival rate with increase of absorbed dose, shown in Figs.…”

Gastro Hepatic Protective Effects of Sildenafil in γ-Irradiated Rats

“…Ionising radiation exposure results in the generation of reactive oxygen species (ROS) that are highly damaging to cells, DNA, lipids and proteins and consequently the whole cell physiology may be changed (Matuo et al, 2008). Excessive production of ROS have been described as one of the probable pathogenic factors of gastric mucosal and hepatic lesions associated with inflammatory processes (Noh et al, 2011 andRiosa et al, 2010).…”